Dose-Response Relationship Between Triglyceride Glucose-Waist Height Ratio Index and Cardiometabolic Multimorbidity Among Chinese Middle-Aged and Older People.
4 affiliations
- 1Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
- 2National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing, China.
- 3Graduate School, Beijing University of Chinese Medicine, Beijing, China.
- 4Geriatrics Department, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan, China.
Abstract
Background
Cardiometabolic multimorbidity (CMM) is a growing public health challenge. The triglyceride glucose-waist height ratio (TyG-WHtR) is a novel index linked to metabolic disorders. This study explores the dose-response relationship between TyG-WHtR and CMM.Methods
Data from the China Health and Retirement Longitudinal Study (CHARLS), including the 2011 baseline survey and the 2018 follow-up survey with an average follow-up duration of 7.0 years, were analyzed. Multivariate logistic regression and restricted cubic spline models assessed the TyG-WHtR-CMM relationship, adjusting for covariates.Results
The study enrolled 6674 individuals, and 1140 patients with cardiometabolic multimorbidity and 5534 patients with non-cardiometabolic multimorbidity were documented over an average follow-up duration of 7.0 years. The fourth TyG-WHtR quartile group (Q4) had the highest CMM risk, with an odds ratio of 1.23 and a 95% confidence interval of 1.20-1.26. The restricted cubic spline regression model showed a nonlinear (p < 0.001) association between TyG-WHtR and CMM. Subgroup analyses showed that the positive association between TyG-WHtR and CMM was evident among females and ex-smokers. A notable interaction was observed between TyG-WHtR and variables like age and marital status.Conclusion
TyG-WHtR is a potential CMM predictor, and maintaining it within a moderate range may help prevent CMM.
Related
- The relationship between C-reactive protein-triglyceride-glucose index and incident cardiometabolic multimorbidity in postmenopausal women: insights from the China Health and Retirement Longitudinal Study (CHARLS).
- Waist-centered triglyceride-glucose markers and inflammation in relation to incident cardiometabolic multimorbidity: a multinational pooled analysis of five aging cohorts
- Triglyceride–HDL cholesterol–glucose body index and cardiometabolic multimorbidity: evidence from a national longitudinal cohort and a subplateau health-screening population
- Association between C-reactive protein-triglyceride-glucose index and one-year all-cause mortality in patients with cardiometabolic multimorbidity
- Neutrophils and lipocalin-2 in triglyceride-glucose body mass index-related cardiometabolic risk among patients with rheumatoid arthritis: a multicenter study
BibTeX
@article{li2026doseresponse,
title = {{Dose-Response Relationship Between Triglyceride Glucose-Waist Height Ratio Index and Cardiometabolic Multimorbidity Among Chinese Middle-Aged and Older People.}},
author = {Lingling Li and Zongliang Yu and Yixuan Feng and Changxin Sun and Lanqing Hu and Xinyi Liu and Liang Li and Min Wu and Longtao Liu},
journal = {Journal of clinical laboratory analysis},
year = {2026},
month = oct,
doi = {10.1002/jcla.70389},
url = {https://europepmc.org/article/MED/42963829},
note = {CC BY},
}
RIS
TY - JOUR
TI - Dose-Response Relationship Between Triglyceride Glucose-Waist Height Ratio Index and Cardiometabolic Multimorbidity Among Chinese Middle-Aged and Older People.
AU - Lingling Li
AU - Zongliang Yu
AU - Yixuan Feng
AU - Changxin Sun
AU - Lanqing Hu
AU - Xinyi Liu
AU - Liang Li
AU - Min Wu
AU - Longtao Liu
PY - 2026
DA - 2026/10/30
JO - Journal of clinical laboratory analysis
DO - 10.1002/jcla.70389
UR - https://europepmc.org/article/MED/42963829
AB - Background Cardiometabolic multimorbidity (CMM) is a growing public health challenge. The triglyceride glucose-waist height ratio (TyG-WHtR) is a novel index linked to metabolic disorders. This study explores the dose-response relationship between TyG-WHtR and CMM.Methods Data from the China Health and Retirement Longitudinal Study (CHARLS), including the 2011 baseline survey and the 2018 follow-up survey with an average follow-up duration of 7.0 years, were analyzed. Multivariate logistic regression and restricted cubic spline models assessed the TyG-WHtR-CMM relationship, adjusting for covariates.Results The study enrolled 6674 individuals, and 1140 patients with cardiometabolic multimorbidity and 5534 patients with non-cardiometabolic multimorbidity were documented over an average follow-up duration of 7.0 years. The fourth TyG-WHtR quartile group (Q4) had the highest CMM risk, with an odds ratio of 1.23 and a 95% confidence interval of 1.20-1.26. The restricted cubic spline regression model showed a nonlinear (p < 0.001) association between TyG-WHtR and CMM. Subgroup analyses showed that the positive association between TyG-WHtR and CMM was evident among females and ex-smokers. A notable interaction was observed between TyG-WHtR and variables like age and marital status.Conclusion TyG-WHtR is a potential CMM predictor, and maintaining it within a moderate range may help prevent CMM.
SN - 0887-8013
SN - 1098-2825
ER -