2026 Asia Pacific Heart Rhythm Society (APHRS) Guidelines (Part II) on Stroke Prevention in Atrial Fibrillation.
15 affiliations
- 1Cardiovascular Center Taipei Veterans General Hospital and National Yang Ming Chiao Tung University Taipei Taiwan.
- 2Institute of Life Course and Medical Sciences University of Liverpool Liverpool UK.
- 3Department of Clinical Medicine Aalborg University Aalborg Denmark.
- 4Department of Cardiology, Lipidology and Internal Medicine With Intensive Coronary Care Unit Medical University of Bialystok Bialystok Poland.
- 5Cardiovascular Department Chang Gung Memorial Hospital Taoyuan Taiwan.
- 6Department of Internal Medicine Seoul National University Hospital Seoul Republic of Korea.
- 7Department of Internal Medicine Seoul National University College of Medicine Seoul Republic of Korea.
- 8Division of Cardiology the First Affiliated Hospital With Nanjing Medical University Nanjing China.
- 9Division of Cardiology, Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of Korea.
- 10Department of Biomedical Imaging and Radiological Sciences National Yang Ming Chiao Tung University Taipei Taiwan.
- 11Division of Cardiology Saiseikai Kumamoto Hospital Kumamoto Japan.
- 12Cardiology Division, Department of Medicine, Queen Mary Hospital The University of Hong Kong Hong Kong SAR China.
- 13Division of Cardiology, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand.
- 14Centre for Heart Rhythm Disorders Adelaide University Adelaide Australia.
- 15Department of Cardiovascular Medicine Kyorin University School of Medicine Mitaka Tokyo Japan.
Abstract
The 2026 Asia Pacific Heart Rhythm Society (APHRS) Guidelines represent the first comprehensive APHRS guidelines dedicated to the management of atrial fibrillation (AF) and comprise four parts covering epidemiology, detection/screening and integrated care; stroke prevention; rate and rhythm control; and lifestyle risk factor and comorbidity management. Part II focuses on stroke prevention in AF, integrating contemporary global evidence with data and clinical considerations specific to the Asia-Pacific region. It provides evidence-based and practical recommendations for stroke and bleeding risk assessment, oral anticoagulation, selection and appropriate dosing of direct oral anticoagulants, management of patients with special or complex clinical characteristics, and left atrial appendage occlusion. Particular attention is given to issues (and evidence) highly relevant to Asia-Pacific populations, including the evolving risk of ischemic stroke, appropriate anticoagulant dosing, renal function assessment, and balancing thromboembolic and bleeding risks. These recommendations aim to support individualized clinical decision-making, promote appropriate use of stroke-prevention strategies, and improve outcomes for patients with AF across the Asia-Pacific region.
Related
- 2026 Asia Pacific Heart Rhythm Society (APHRS) Guidelines (Part III) on Rate and Rhythm Control in Atrial Fibrillation.
- 2026 Asia Pacific Heart Rhythm Society (APHRS) Guidelines (Part I) on Epidemiology, Detection/Screening and Integrated Patient Care in Atrial Fibrillation.
- 2026 Asia Pacific Heart Rhythm Society (APHRS) Guidelines (Part IV) on Comprehensive Lifestyle Risk Factor and Comorbidity Management in Atrial Fibrillation.
- Beyond Sinus Rhythm: Rhythm Control and Mechanism-Based Secondary Prevention in Atrial Fibrillation–Related Stroke
- Cardiometabolic therapy for rhythm control: a case report of refractory atrial fibrillation resolving after initiation of semaglutide for obesity
BibTeX
@article{chao20262026,
title = {{2026 Asia Pacific Heart Rhythm Society (APHRS) Guidelines (Part II) on Stroke Prevention in Atrial Fibrillation.}},
author = {Tze-Fan Chao and Gregory Y H Lip and Yi-Hsin Chan and So-Ryoung Lee and Mingfang Li and Daehoon Kim and Ling Kuo and Ken Okumura and Hung-Fat Tse and Eue-Keun Choi and Minglong Chen and Boyoung Joung and Rungroj Krittayaphong and Melissa E Middeldorp and Kyoko Soejima and Hui-Nam Pak},
journal = {Journal of arrhythmia},
year = {2026},
month = oct,
doi = {10.1002/joa3.70491},
url = {https://europepmc.org/article/MED/42923502},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - 2026 Asia Pacific Heart Rhythm Society (APHRS) Guidelines (Part II) on Stroke Prevention in Atrial Fibrillation.
AU - Tze-Fan Chao
AU - Gregory Y H Lip
AU - Yi-Hsin Chan
AU - So-Ryoung Lee
AU - Mingfang Li
AU - Daehoon Kim
AU - Ling Kuo
AU - Ken Okumura
AU - Hung-Fat Tse
AU - Eue-Keun Choi
AU - Minglong Chen
AU - Boyoung Joung
AU - Rungroj Krittayaphong
AU - Melissa E Middeldorp
AU - Kyoko Soejima
AU - Hui-Nam Pak
PY - 2026
DA - 2026/10/21
JO - Journal of arrhythmia
DO - 10.1002/joa3.70491
UR - https://europepmc.org/article/MED/42923502
AB - The 2026 Asia Pacific Heart Rhythm Society (APHRS) Guidelines represent the first comprehensive APHRS guidelines dedicated to the management of atrial fibrillation (AF) and comprise four parts covering epidemiology, detection/screening and integrated care; stroke prevention; rate and rhythm control; and lifestyle risk factor and comorbidity management. Part II focuses on stroke prevention in AF, integrating contemporary global evidence with data and clinical considerations specific to the Asia-Pacific region. It provides evidence-based and practical recommendations for stroke and bleeding risk assessment, oral anticoagulation, selection and appropriate dosing of direct oral anticoagulants, management of patients with special or complex clinical characteristics, and left atrial appendage occlusion. Particular attention is given to issues (and evidence) highly relevant to Asia-Pacific populations, including the evolving risk of ischemic stroke, appropriate anticoagulant dosing, renal function assessment, and balancing thromboembolic and bleeding risks. These recommendations aim to support individualized clinical decision-making, promote appropriate use of stroke-prevention strategies, and improve outcomes for patients with AF across the Asia-Pacific region.
SN - 1880-4276
SN - 1883-2148
ER -