Skip to content
DraconiticResearch
Search Sources API
181,713 studies31 sourcesUpdated 2 min ago
PreprintCC BY-NCbioRxiv

FMNL1 polymerized actin filaments complete mitochondrial division downstream of Golgi-derived vesicles

  • B. Tabori
  • A. Ghosh
  • M. R. Zavala
  • R. Chakrabarti1
  1. 1Thomas Jefferson University
Read full textPDFDOICite

Abstract

Mitochondrial division includes contributions from several organelles yet the molecular machinery that facilitates the final Drp1-induced scission of the OMM is largely elusive. We elucidate that FMNL1, a formin family actin assembly factor, is recruited to the mitochondrial division sites through the TGN vesicles in a calcium dependent pathway to complete mitochondrial division. FMNL1 is activated specifically by Cdc42 that generates actin filaments to complete division of the OMM in Drp1 and actin-dependent pathway. Depletion of FMNL1 enhances early events in mitochondrial division pathway characterized by enhanced ER-mitochondrial contacts and increased Drp1 and TGN vesicles on mitochondria which still results in failed mitochondrial division.

Related

  1. The complete mitochondrial genome of Reptalus artemisiae (Becker, 1865) (Hemiptera: Cixiidae)
    Bojan Duduk, Nikola Stanojević, Emil Rekanović
    Mitochondrial DNA. Part B, ResourcesPeer-reviewedCC BY-NCFull textGeneral biologyEurope PMC
  2. The complete mitochondrial genome of Neomyia gavisa (Walker, 1859) (Diptera: Muscidae)
    Linwen Zhou, Shuangmei Ding, Ding Yang +1
    Mitochondrial DNA. Part B, ResourcesPeer-reviewedCC BYFull textGeneral biologyEurope PMC
  3. The complete mitochondrial genomes of Colias lada and Colias wanda (Lepidoptera: Pieridae: Coliadinae) and their phylogenetic analyses
    Wang Sunle, Gu Xuesong, Zhu Zhenyao +1
    Mitochondrial DNA. Part B, ResourcesPeer-reviewedCC BY-NCFull textGeneral biologyEurope PMC
  4. Structural characteristics and phylogenetic analysis of the complete mitochondrial genome of Sanguisorba officinalis (Rosaceae)
    Dijing Wu, Chunyu Tian, Yanting Yang +6
    BMC GenomicsPeer-reviewedCC BY-NC-ND 4.0Plant biologyCrossref
  5. Characterization and phylogenetic analysis of the complete mitochondrial genome of Gomphus clavatus (pers.) Gray, 1821
    Bowen Zan, Xiao Zou, Liangju Li +5
    Mitochondrial DNA. Part B, ResourcesPeer-reviewedCC BYFull textGeneral biologyEurope PMC

Cite

BibTeXRIS
BibTeX
@misc{tabori2026fmnl1,
  title = {{FMNL1 polymerized actin filaments complete mitochondrial division downstream of Golgi-derived vesicles}},
  author = {B. Tabori and A. Ghosh and M. R. Zavala and R. Chakrabarti},
  howpublished = {bioRxiv},
  year = {2026},
  month = oct,
  doi = {10.64898/2026.10.21.760700},
  url = {https://www.biorxiv.org/content/10.64898/2026.10.21.760700v1},
  note = {CC BY-NC},
}
RIS
TY  - UNPB
TI  - FMNL1 polymerized actin filaments complete mitochondrial division downstream of Golgi-derived vesicles
AU  - B. Tabori
AU  - A. Ghosh
AU  - M. R. Zavala
AU  - R. Chakrabarti
PY  - 2026
DA  - 2026/10/21
PB  - bioRxiv
DO  - 10.64898/2026.10.21.760700
UR  - https://www.biorxiv.org/content/10.64898/2026.10.21.760700v1
AB  - Mitochondrial division includes contributions from several organelles yet the molecular machinery that facilitates the final Drp1-induced scission of the OMM is largely elusive. We elucidate that FMNL1, a formin family actin assembly factor, is recruited to the mitochondrial division sites through the TGN vesicles in a calcium dependent pathway to complete mitochondrial division. FMNL1 is activated specifically by Cdc42 that generates actin filaments to complete division of the OMM in Drp1 and actin-dependent pathway. Depletion of FMNL1 enhances early events in mitochondrial division pathway characterized by enhanced ER-mitochondrial contacts and increased Drp1 and TGN vesicles on mitochondria which still results in failed mitochondrial division.
ER  -