Associations of Gut Microbiota Composition and Fecal Metabolomic Profiles in Patients With Acquired Premature Ejaculation: A Cross-Sectional Pilot Study
5 affiliations
- 1School of Medicine, Southeast University, Nanjing, Jiangsu, China
- 2Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China
- 3Department of Traditional Chinese Medicine, Qinghai University Medical College, Xining, China
- 4Reproductive Center, Zhongda Hospital, Southeast University, Nanjing, China
- 5Andrology Department of Integrative Medicine, Zhongda Hospital, Southeast University, Nanjing, China
Abstract
Premature ejaculation (PE) is a prevalent male sexual disorder with an incompletely understood pathogenesis and limited effective therapeutic strategies. Although the gut microbiota has been implicated in several diseases, its association with PE remains unclear. Metabolomic analyses and metagenomic sequencing were performed to compare the intestinal microbiota profiles between 20 patients with PE and 20 healthy controls, investigating the association between PE and gut microbiota. Comprehensive analysis revealed distinct microbial signatures between PE and control groups. The PE group exhibited significantly reduced relative abundances of Bifidobacteriaceae bacterium, Blautia, Coprobacillus, Ruminococcus sp. ctHOG1, Siphoviridae, and Alistipes. Metabolomic profiling identified 150 upregulated and 73 downregulated metabolites between the two groups. Kyoto encyclopedia of genes and genomes pathway enrichment analysis indicated significant enrichment of several potential signaling pathways in the PE group. This study characterized distinct gut microbiota features in patients with PE compared with healthy controls and investigated microbiota-associated pathways potentially related to PE through integrated metabolomics analysis. The findings provide preliminary insights into microbiome-associated alterations in PE.
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BibTeX
@article{huang2026associations,
title = {{Associations of Gut Microbiota Composition and Fecal Metabolomic Profiles in Patients With Acquired Premature Ejaculation: A Cross-Sectional Pilot Study}},
author = {Shuyi Huang and Sijia Sun and Zhou Zhao and Dawei Gao and Wenxiu Zhang and Nianchao Zhou and Yihan Jin and Baofang Jin and Dalin Sun},
journal = {American Journal of Men's Health},
year = {2026},
month = sep,
doi = {10.1177/15579883261493263},
url = {https://doi.org/10.1177/15579883261493263},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Associations of Gut Microbiota Composition and Fecal Metabolomic Profiles in Patients With Acquired Premature Ejaculation: A Cross-Sectional Pilot Study
AU - Shuyi Huang
AU - Sijia Sun
AU - Zhou Zhao
AU - Dawei Gao
AU - Wenxiu Zhang
AU - Nianchao Zhou
AU - Yihan Jin
AU - Baofang Jin
AU - Dalin Sun
PY - 2026
DA - 2026/09/30
JO - American Journal of Men's Health
DO - 10.1177/15579883261493263
UR - https://doi.org/10.1177/15579883261493263
AB - Premature ejaculation (PE) is a prevalent male sexual disorder with an incompletely understood pathogenesis and limited effective therapeutic strategies. Although the gut microbiota has been implicated in several diseases, its association with PE remains unclear. Metabolomic analyses and metagenomic sequencing were performed to compare the intestinal microbiota profiles between 20 patients with PE and 20 healthy controls, investigating the association between PE and gut microbiota. Comprehensive analysis revealed distinct microbial signatures between PE and control groups. The PE group exhibited significantly reduced relative abundances of Bifidobacteriaceae bacterium, Blautia, Coprobacillus, Ruminococcus sp. ctHOG1, Siphoviridae, and Alistipes. Metabolomic profiling identified 150 upregulated and 73 downregulated metabolites between the two groups. Kyoto encyclopedia of genes and genomes pathway enrichment analysis indicated significant enrichment of several potential signaling pathways in the PE group. This study characterized distinct gut microbiota features in patients with PE compared with healthy controls and investigated microbiota-associated pathways potentially related to PE through integrated metabolomics analysis. The findings provide preliminary insights into microbiome-associated alterations in PE.
SN - 1557-9883
SN - 1557-9891
ER -