Toward Property-Directed Catalytic Skeletal Editing of Functional Organic Materials
Abstract
Late-stage skeletal editing has emerged as a useful strategy in synthetic and medicinal chemistry for altering molecular frameworks by atom insertion, deletion, replacement, or bond reorganization. Functional organic molecules and materials are commonly optimized through peripheral substitution and de novo framework construction. Direct modification of an existing skeleton provides a complementary means of tuning electronic structure, molecular shape, chirality, packing, and processability. Herein we examine catalytic skeletal editing with an emphasis on functional organic materials, specifically π-conjugated molecules, dyes, polymers, and covalent frameworks. Representative examples are evaluated in terms of catalytic status and experimentally demonstrated properties. Key requirements for broader application include site selectivity, element transfer, catalyst compatibility, and control of editing extent in extended materials. The emerging opportunity is to move skeletal editing from reaction-centered diversification toward catalyst-controlled, property-directed modification.
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BibTeX
@misc{koike2026toward,
title = {{Toward Property-Directed Catalytic Skeletal Editing of Functional Organic Materials}},
author = {Taichi Koike and Sajan Pradhan and Kenichiro Itami},
howpublished = {ChemRxiv},
year = {2026},
month = sep,
doi = {10.26434/chemrxiv.15008875/v1},
url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008875/v1},
note = {CC BY-NC},
}
RIS
TY - UNPB
TI - Toward Property-Directed Catalytic Skeletal Editing of Functional Organic Materials
AU - Taichi Koike
AU - Sajan Pradhan
AU - Kenichiro Itami
PY - 2026
DA - 2026/09/15
PB - ChemRxiv
DO - 10.26434/chemrxiv.15008875/v1
UR - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008875/v1
AB - Late-stage skeletal editing has emerged as a useful strategy in synthetic and medicinal chemistry for altering molecular frameworks by atom insertion, deletion, replacement, or bond reorganization. Functional organic molecules and materials are commonly optimized through peripheral substitution and de novo framework construction. Direct modification of an existing skeleton provides a complementary means of tuning electronic structure, molecular shape, chirality, packing, and processability. Herein we examine catalytic skeletal editing with an emphasis on functional organic materials, specifically π-conjugated molecules, dyes, polymers, and covalent frameworks. Representative examples are evaluated in terms of catalytic status and experimentally demonstrated properties. Key requirements for broader application include site selectivity, element transfer, catalyst compatibility, and control of editing extent in extended materials. The emerging opportunity is to move skeletal editing from reaction-centered diversification toward catalyst-controlled, property-directed modification.
ER -