Primary Intratesticular glomus tumor: a rare mesenchymal neoplasm and a diagnostic challenge.
- 1Department of Pathology, Kermanshah University of Medical Sciences, Imam Reza Hospital Complex, Parastar Boulevard, Kermanshah, Kermanshah Province, 6714415333, Iran.
- 2Department of Pathology, School of Medical Sciences, Islamic Azad University, Basij Street, Ardabil, Ardabil Province, 5615731567, Iran.
Abstract
Background
Glomus tumors are rare mesenchymal neoplasms of perivascular origin, most commonly found in the dermis or subcutis of distal extremities. Testicular involvement is exceptionally uncommon and poses a diagnostic challenge due to histopathologic similarities with other intratesticular tumors.Case presentation
We describe an 85-year-old man with a painless, gradually enlarging left testicular mass. Imaging and tumor markers were inconclusive. Radical orchiectomy revealed a well-circumscribed intratesticular lesion. Histology showed uniform round cells with eosinophilic cytoplasm arranged around vascular spaces. Immunohistochemistry demonstrated strong positivity for SMA and negativity for germ cell, stromal, neuroendocrine, and melanocytic markers, confirming the diagnosis of a primary intratesticular glomus tumor.Conclusion
This case underscores the need to consider rare mesenchymal tumors in the differential diagnosis of testicular masses in elderly patients and highlights the pivotal role of immunohistochemistry in establishing an accurate diagnosis.
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BibTeX
@article{aminparast2026primary,
title = {{Primary Intratesticular glomus tumor: a rare mesenchymal neoplasm and a diagnostic challenge.}},
author = {Zahra Aminparast and Payam Nikjo and Donya Rahmati and Paria Nikjo},
journal = {Oxford medical case reports},
year = {2026},
month = oct,
doi = {10.1093/omcr/omag075},
url = {https://europepmc.org/article/MED/42898342},
note = {CC BY},
}
RIS
TY - JOUR
TI - Primary Intratesticular glomus tumor: a rare mesenchymal neoplasm and a diagnostic challenge.
AU - Zahra Aminparast
AU - Payam Nikjo
AU - Donya Rahmati
AU - Paria Nikjo
PY - 2026
DA - 2026/10/04
JO - Oxford medical case reports
DO - 10.1093/omcr/omag075
UR - https://europepmc.org/article/MED/42898342
AB - Background Glomus tumors are rare mesenchymal neoplasms of perivascular origin, most commonly found in the dermis or subcutis of distal extremities. Testicular involvement is exceptionally uncommon and poses a diagnostic challenge due to histopathologic similarities with other intratesticular tumors.Case presentation We describe an 85-year-old man with a painless, gradually enlarging left testicular mass. Imaging and tumor markers were inconclusive. Radical orchiectomy revealed a well-circumscribed intratesticular lesion. Histology showed uniform round cells with eosinophilic cytoplasm arranged around vascular spaces. Immunohistochemistry demonstrated strong positivity for SMA and negativity for germ cell, stromal, neuroendocrine, and melanocytic markers, confirming the diagnosis of a primary intratesticular glomus tumor.Conclusion This case underscores the need to consider rare mesenchymal tumors in the differential diagnosis of testicular masses in elderly patients and highlights the pivotal role of immunohistochemistry in establishing an accurate diagnosis.
SN - 2053-8855
ER -