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Peer-reviewedCC BY-NCAnnals of dermatology

Increased Risk of Psoriasis in Young Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Retrospective Cohort Study.

  • Hyun Ji Lee1
  • Jonghee Chung1
  • Kyungdo Han2
  • Miri Kim3
  1. 1Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  2. 2Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea.
  3. 3Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. [email protected].
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Abstract

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a newly defined condition linked to cardiometabolic risk. Its association with psoriasis remains unclear.Objective

To evaluate the association between MASLD and psoriasis risk in young adults in Korea.Methods

A retrospective cohort study was conducted using data from 6,400,590 adults aged 20-39 years in the Korean National Health Insurance Service. Participants were classified into seven study-defined, mutually exclusive SLD groups, and incident psoriasis was identified by International Statistical Classification of Diseases and Related Health Problems, 10th Revision codes. Cox proportional hazards models estimated hazard ratios (HRs).Results

During a median follow-up of 9.1 years, 170,921 individuals developed psoriasis. MASLD was significantly associated with increased psoriasis risk (adjusted HR, 1.13). Risk estimates varied across the study-defined groups.Conclusion

MASLD and related study-defined groups were associated with psoriasis risk in young adults.

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Cite

BibTeXRIS
BibTeX
@article{lee2026increased,
  title = {{Increased Risk of Psoriasis in Young Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Retrospective Cohort Study.}},
  author = {Hyun Ji Lee and Jonghee Chung and Kyungdo Han and Miri Kim},
  journal = {Annals of dermatology},
  year = {2026},
  month = oct,
  doi = {10.5021/ad.25.240},
  url = {https://europepmc.org/article/MED/42845208},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Increased Risk of Psoriasis in Young Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Retrospective Cohort Study.
AU  - Hyun Ji Lee
AU  - Jonghee Chung
AU  - Kyungdo Han
AU  - Miri Kim
PY  - 2026
DA  - 2026/10/01
JO  - Annals of dermatology
DO  - 10.5021/ad.25.240
UR  - https://europepmc.org/article/MED/42845208
AB  - Background  Metabolic dysfunction-associated steatotic liver disease (MASLD) is a newly defined condition linked to cardiometabolic risk. Its association with psoriasis remains unclear.Objective  To evaluate the association between MASLD and psoriasis risk in young adults in Korea.Methods  A retrospective cohort study was conducted using data from 6,400,590 adults aged 20-39 years in the Korean National Health Insurance Service. Participants were classified into seven study-defined, mutually exclusive SLD groups, and incident psoriasis was identified by International Statistical Classification of Diseases and Related Health Problems, 10th Revision codes. Cox proportional hazards models estimated hazard ratios (HRs).Results  During a median follow-up of 9.1 years, 170,921 individuals developed psoriasis. MASLD was significantly associated with increased psoriasis risk (adjusted HR, 1.13). Risk estimates varied across the study-defined groups.Conclusion  MASLD and related study-defined groups were associated with psoriasis risk in young adults.
SN  - 1013-9087
SN  - 2005-3894
ER  -