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Peer-reviewedCC BY 4.0Frontiers in Immunology

Extracellular vesicle-mediated immune remodeling in cutaneous wound repair

  • Gun Woo Lee1,2,3
  • Wook-Tae Park4
  • Min-Soo Seo5
  • Sangbum Park3,6,7
7 affiliations
  1. 1Department of Orthopedic Surgery, Ulsan Medical Center
  2. 2Cellexobio, Ltd.
  3. 3Institute for Quantitative Health Science and Engineering (IQ), Michigan State University
  4. 4Department of Orthopedic Surgery, Yeungnam University College of Medicine
  5. 5Laboratory of Veterinary Tissue Engineering, College of Veterinary Medicine, Kyungpook National University
  6. 6Department of Medicine, College of Human Medicine, Michigan State University
  7. 7Department of Pharmacology and Toxicology, College of Human Medicine, Michigan State University
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Abstract

Extracellular vesicles (EVs) are emerging cell-free therapeutic platforms for cutaneous wound repair that regulate diverse cellular processes, including intercellular communication, inflammation, angiogenesis, extracellular matrix remodeling, and tissue repair. Recent advances in parental cell preconditioning, EV engineering, smart EV design, and biomaterial-assisted delivery have further enhanced the therapeutic potential of EV-based approaches. These advances have stimulated growing interest in applying EVs to skin wound repair, where EVs act on resident skin cells and immune cells to promote regenerative healing. In particular, macrophage reprogramming is well characterized, whereas EV-mediated regulation of other immune-cell populations remains less clearly defined. Standardized EV production, reliable potency assays, and dynamic in vivo approaches will be essential for defining how EVs coordinate regenerative and immune-regulatory processes. This review discusses EV-mediated cutaneous wound repair with emphasis on temporal and cell-specific immune remodeling, regenerative mechanisms, and translational challenges.

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Cite

BibTeXRIS
BibTeX
@article{lee2026extracellular,
  title = {{Extracellular vesicle-mediated immune remodeling in cutaneous wound repair}},
  author = {Gun Woo Lee and Wook-Tae Park and Min-Soo Seo and Sangbum Park},
  journal = {Frontiers in Immunology},
  year = {2026},
  month = oct,
  doi = {10.3389/fimmu.2026.1938968},
  url = {https://www.frontiersin.org/articles/10.3389/fimmu.2026.1938968/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Extracellular vesicle-mediated immune remodeling in cutaneous wound repair
AU  - Gun Woo Lee
AU  - Wook-Tae Park
AU  - Min-Soo Seo
AU  - Sangbum Park
PY  - 2026
DA  - 2026/10/06
JO  - Frontiers in Immunology
DO  - 10.3389/fimmu.2026.1938968
UR  - https://www.frontiersin.org/articles/10.3389/fimmu.2026.1938968/full
AB  - Extracellular vesicles (EVs) are emerging cell-free therapeutic platforms for cutaneous wound repair that regulate diverse cellular processes, including intercellular communication, inflammation, angiogenesis, extracellular matrix remodeling, and tissue repair. Recent advances in parental cell preconditioning, EV engineering, smart EV design, and biomaterial-assisted delivery have further enhanced the therapeutic potential of EV-based approaches. These advances have stimulated growing interest in applying EVs to skin wound repair, where EVs act on resident skin cells and immune cells to promote regenerative healing. In particular, macrophage reprogramming is well characterized, whereas EV-mediated regulation of other immune-cell populations remains less clearly defined. Standardized EV production, reliable potency assays, and dynamic in vivo approaches will be essential for defining how EVs coordinate regenerative and immune-regulatory processes. This review discusses EV-mediated cutaneous wound repair with emphasis on temporal and cell-specific immune remodeling, regenerative mechanisms, and translational challenges.
SN  - 1664-3224
ER  -