Channel expression aligns with dendritic conductance load in the reinforcing, not compensatory, direction in cortical GABAergic neurons
- 1University of Picardie Jules Verne
Abstract
Neurons could offset the conductance load imposed by their dendrites through channel expression (compensation), or channel expression could move with that load (reinforcement); which arrangement holds in adult cortex is unknown. Writing rheobase as the product of input conductance and an effective-voltage factor turns the question into a sign test. In mouse cortical GABAergic Patch-seq neurons, after removal of transcriptomic type and covariates, an out-of-fold channel-gene score co-varies positively with residual input conductance (median Spearman {rho} = 0.32 over 20 cross-fitting splits, n = 493) and with a conductance score predicted from dendritic morphology alone ({rho} = 0.23, n = 483). The association is carried mainly by Sst and Pvalb cells and is close to zero in Vip cells. Its slope on the compensation axis is 0.13, against -1 for compensation and 0 for independence, so the finding concerns direction rather than magnitude: it excludes a population-wide compensation rule without implying strong amplification. Reduced NEURON models show that a compensatory correction is biophysically feasible, and the morphology-derived conductance predictor transfers from mouse to human reconstructions ({rho} = 0.27, n = 128).
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BibTeX
@misc{cirrincione2026channel,
title = {{Channel expression aligns with dendritic conductance load in the reinforcing, not compensatory, direction in cortical GABAergic neurons}},
author = {G. Cirrincione and F. Grassia},
howpublished = {bioRxiv},
year = {2026},
month = nov,
doi = {10.64898/2026.11.11.765852},
url = {https://www.biorxiv.org/content/10.64898/2026.11.11.765852v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - Channel expression aligns with dendritic conductance load in the reinforcing, not compensatory, direction in cortical GABAergic neurons
AU - G. Cirrincione
AU - F. Grassia
PY - 2026
DA - 2026/11/11
PB - bioRxiv
DO - 10.64898/2026.11.11.765852
UR - https://www.biorxiv.org/content/10.64898/2026.11.11.765852v1
AB - Neurons could offset the conductance load imposed by their dendrites through channel expression (compensation), or channel expression could move with that load (reinforcement); which arrangement holds in adult cortex is unknown. Writing rheobase as the product of input conductance and an effective-voltage factor turns the question into a sign test. In mouse cortical GABAergic Patch-seq neurons, after removal of transcriptomic type and covariates, an out-of-fold channel-gene score co-varies positively with residual input conductance (median Spearman {rho} = 0.32 over 20 cross-fitting splits, n = 493) and with a conductance score predicted from dendritic morphology alone ({rho} = 0.23, n = 483). The association is carried mainly by Sst and Pvalb cells and is close to zero in Vip cells. Its slope on the compensation axis is 0.13, against -1 for compensation and 0 for independence, so the finding concerns direction rather than magnitude: it excludes a population-wide compensation rule without implying strong amplification. Reduced NEURON models show that a compensatory correction is biophysically feasible, and the morphology-derived conductance predictor transfers from mouse to human reconstructions ({rho} = 0.27, n = 128).
ER -