Skip to content
DraconiticResearch
Search Sources API
220,788 studies31 sourcesUpdated 41 min ago
Peer-reviewedCC BY 4.0Cureus

Pediatric Orbital Langerhans Cell Histiocytosis With Dural Adherence Requiring Orbital Roof Reconstruction: A Case Report

  • Christopher Branstetter1
  • Robert M Branstetter2
  • Brandon Byrd3
  • Oritsejolomi Roberts4
  • Mohamad Masoumy5
5 affiliations
  1. 1School of Medicine, Louisiana State University Health Sciences Center New Orleans, New Orleans, USA
  2. 2Department of Ophthalmology, Louisiana State University Health Sciences Center New Orleans, New Orleans, USA
  3. 3Department of Surgery, Division of Plastic and Reconstructive Surgery, Louisiana State University, New Orleans, USA
  4. 4Department of Neurosurgery, Louisiana State University Health Sciences Center New Orleans, New Orleans, USA
  5. 5Department of Surgery, Division of Plastic and Reconstructive Surgery, Louisiana State University Health Sciences Center New Orleans, New Orleans, USA
Read full textPDFDOICite

Abstract

We present a rare case describing the clinical course of a seven-year-old girl presenting with left periorbital swelling, initially managed as preseptal cellulitis. The periorbital swelling was unresponsive to multiple courses of antibiotics. Magnetic resonance imaging (MRI) of the head and orbits revealed a 2.3 × 2.4 × 2.1 cm mass involving the superolateral aspect of the left orbit. The lesion was predominantly hypointense on T1-weighted images and demonstrated mixed signal intensity on T2-weighted images. Post-contrast imaging demonstrated peripheral enhancement with internal septations.

Concerns for mass effect due to the tumor size and location prompted surgical resection, with histopathologic examination confirming the diagnosis of Langerhans cell histiocytosis (LCH). Given the central nervous system (CNS)-risk orbital location, the patient completed a 52-week course of vinblastine and prednisone, consistent with a standard 12-month regimen. At the 12-month clinical follow-up after completion of chemotherapy, she remained clinically stable without evidence of recurrence. This case highlights the importance of considering rare diagnoses in pediatric patients with atypical or nonresponsive symptoms, particularly when clinical or laboratory findings do not support an infectious etiology.

Related

  1. Langerhans Cell Histiocytosis of the Vulva: A Pediatric Case.
    Marina Romero Navarrete, María Elisa Vega Memije, Sabrina Escandón Pérez +3
    Dermatology practical & conceptualPeer-reviewedCC BY-NCFull textPhysiologyEurope PMC
  2. Extensive vulvar and perianal langerhans cell histiocytosis with clinical improvement during low-dose thalidomide and topical therapy: a case report
    Pan Zou, Xiao Mei Zhu
    Frontiers in medicinePeer-reviewedCC BYFull textGeneral medicineEurope PMC
  3. Adult-onset Langerhans cell histiocytosis in an elderly female with cutaneous and nodal involvement: A case report
    Pei-Yun Ho, Hsingjin-Eugene Liu, Ying-Yi Chiang
    Dermatologica SinicaPeer-reviewedCC BY-NC-SAFull textPhysiologyDOAJ
  4. Adult single-system cutaneous Langerhans cell histiocytosis presenting with hypopigmented lesions in skin of color: A case report and literature review
    Amira Muftah, Zachary Dwyer, Adnan Mansoor +1
    JAAD Case ReportsPeer-reviewedCC BY 4.0Full textGeneral medicinePMC
  5. Langerhans-Cell Histiocytosis In Children: A Bicentric Study From Tunisia Histiocytose Langerhansienne pédiatrique: Étude bicentrique tunisienne
    Samia Rekaia, Manel Gouja, Feten Fedhila +11
    La Tunisie medicalePeer-reviewedCC BY-NC-NDFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{branstetter2026pediatric,
  title = {{Pediatric Orbital Langerhans Cell Histiocytosis With Dural Adherence Requiring Orbital Roof Reconstruction: A Case Report}},
  author = {Christopher Branstetter and Robert M Branstetter and Brandon Byrd and Oritsejolomi Roberts and Mohamad Masoumy},
  journal = {Cureus},
  year = {2026},
  month = oct,
  doi = {10.7759/cureus.117742},
  url = {https://doi.org/10.7759/cureus.117742},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Pediatric Orbital Langerhans Cell Histiocytosis With Dural Adherence Requiring Orbital Roof Reconstruction: A Case Report
AU  - Christopher Branstetter
AU  - Robert M Branstetter
AU  - Brandon Byrd
AU  - Oritsejolomi Roberts
AU  - Mohamad Masoumy
PY  - 2026
DA  - 2026/10/10
JO  - Cureus
DO  - 10.7759/cureus.117742
UR  - https://doi.org/10.7759/cureus.117742
AB  - We present a rare case describing the clinical course of a seven-year-old girl presenting with left periorbital swelling, initially managed as preseptal cellulitis. The periorbital swelling was unresponsive to multiple courses of antibiotics. Magnetic resonance imaging (MRI) of the head and orbits revealed a 2.3 × 2.4 × 2.1 cm mass involving the superolateral aspect of the left orbit. The lesion was predominantly hypointense on T1-weighted images and demonstrated mixed signal intensity on T2-weighted images. Post-contrast imaging demonstrated peripheral enhancement with internal septations.  Concerns for mass effect due to the tumor size and location prompted surgical resection, with histopathologic examination confirming the diagnosis of Langerhans cell histiocytosis (LCH). Given the central nervous system (CNS)-risk orbital location, the patient completed a 52-week course of vinblastine and prednisone, consistent with a standard 12-month regimen. At the 12-month clinical follow-up after completion of chemotherapy, she remained clinically stable without evidence of recurrence. This case highlights the importance of considering rare diagnoses in pediatric patients with atypical or nonresponsive symptoms, particularly when clinical or laboratory findings do not support an infectious etiology.
SN  - 2168-8184
ER  -