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Peer-reviewedCC BY 4.0Clinical and Experimental Medicine

Deciphering the mechanistic landscape of notch signaling in autoimmune pathogenesis

  • Ruiyuan Zhang1
  • Shenghao Tu1
  • Weiji Lin1
  • Liang Han1
  • Xin Ba1
  • Jiahui Yan1
  • Yuyao Yang1
  • Yifei Li1
  • Tingting Li1
  • Chennan Li1
  • Guanghuan Li1
  • Zhe Chen1
4 more authors
  • Kai Qin1
  • Ying Huang1
  • Yu Wang1
  • Yao Huang1
  1. 1Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei China
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Abstract

Autoimmune diseases are a group of disorders with multiple etiologies that disrupt normal immunological function, leading to the immune system mistakenly attacking the body’s own tissues. The Notch signaling pathway is a conserved pathway that is in part responsible for multiple cellular behaviors, including proliferation, differentiation, development, and death, through direct cell-to-cell communication. The expression and activation of Notch signaling pathway proteins are aberrantly regulated in autoimmune diseases in a manner that is closely related to their onset and development. We reviewed the functioning of the Notch signaling pathway in several autoimmune disorders, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), primary Sjögren’s syndrome (pSS), juvenile idiopathic arthritis (JIA), idiopathic thrombocytopenic purpura (ITP), multiple sclerosis (MS), autoimmune vasculitis, autoimmune hepatitis (AIH), autoimmune thyroid disease (AITD), autoimmune kidney diseases and type 1 diabetes mellitus (T1DM). We specifically sought to explore the involvement of the Notch signaling pathway in the occurrence and progression of RA to provide ideas and approaches for developing new therapeutic strategies for this autoimmune disease.

Graphical Abstract:

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Cite

BibTeXRIS
BibTeX
@article{zhang2026deciphering,
  title = {{Deciphering the mechanistic landscape of notch signaling in autoimmune pathogenesis}},
  author = {Ruiyuan Zhang and Shenghao Tu and Weiji Lin and Liang Han and Xin Ba and Jiahui Yan and Yuyao Yang and Yifei Li and Tingting Li and Chennan Li and Guanghuan Li and Zhe Chen and Kai Qin and Ying Huang and Yu Wang and Yao Huang},
  journal = {Clinical and Experimental Medicine},
  year = {2026},
  month = jul,
  doi = {10.1007/s10238-026-02272-7},
  url = {https://doi.org/10.1007/s10238-026-02272-7},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Deciphering the mechanistic landscape of notch signaling in autoimmune pathogenesis
AU  - Ruiyuan Zhang
AU  - Shenghao Tu
AU  - Weiji Lin
AU  - Liang Han
AU  - Xin Ba
AU  - Jiahui Yan
AU  - Yuyao Yang
AU  - Yifei Li
AU  - Tingting Li
AU  - Chennan Li
AU  - Guanghuan Li
AU  - Zhe Chen
AU  - Kai Qin
AU  - Ying Huang
AU  - Yu Wang
AU  - Yao Huang
PY  - 2026
DA  - 2026/07/31
JO  - Clinical and Experimental Medicine
DO  - 10.1007/s10238-026-02272-7
UR  - https://doi.org/10.1007/s10238-026-02272-7
AB  - Autoimmune diseases are a group of disorders with multiple etiologies that disrupt normal immunological function, leading to the immune system mistakenly attacking the body’s own tissues. The Notch signaling pathway is a conserved pathway that is in part responsible for multiple cellular behaviors, including proliferation, differentiation, development, and death, through direct cell-to-cell communication. The expression and activation of Notch signaling pathway proteins are aberrantly regulated in autoimmune diseases in a manner that is closely related to their onset and development. We reviewed the functioning of the Notch signaling pathway in several autoimmune disorders, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), primary Sjögren’s syndrome (pSS), juvenile idiopathic arthritis (JIA), idiopathic thrombocytopenic purpura (ITP), multiple sclerosis (MS), autoimmune vasculitis, autoimmune hepatitis (AIH), autoimmune thyroid disease (AITD), autoimmune kidney diseases and type 1 diabetes mellitus (T1DM). We specifically sought to explore the involvement of the Notch signaling pathway in the occurrence and progression of RA to provide ideas and approaches for developing new therapeutic strategies for this autoimmune disease.  Graphical Abstract:
SN  - 1591-8890
SN  - 1591-9528
ER  -