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Peer-reviewedCC BY 4.0PLOS One

OphthoEvidence report: Baseline structural optical coherence tomography biomarkers as predictors of visual outcomes following full-thickness macular hole surgery: A systematic review and meta-analysis protocol

  • Sahar Khademioore1
  • João Pedro Lima2
  • Dena Zeraatkar3
  • Sadia Mahmood4
  • Sara Khademioureh5
  • Charles C. Wykoff6
  • Peter K. Kaiser7
  • Tien-Yin Wong8
  • Jiayuan Cheng9
  • Mengda Li10
  • Varun Chaudhary11
11 affiliations
  1. 1Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada
  2. 2Thomas Kevill Advanced Vitreoretinal Imaging (AVI) Lab, St Joseph’s Healthcare, Hamilton, ON, Canada
  3. 3Department of Surgery, McMaster University, Hamilton, ON, Canada
  4. 4Department of Anesthesia, McMaster University, Hamilton, ON, Canada
  5. 5School of Public Health, University of Alberta, Edmonton, Alberta, Canada
  6. 6Retina Consultants of Texas, Houston, Texas, United States of America
  7. 7Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
  8. 8Beijing Visual Science and Translational Eye Research Institute, School of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China
  9. 9Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
  10. 10Tsinghua Medicine, Tsinghua University, Beijing, China
  11. 11School of Biomedical Engineering, Tsinghua Medicine, Tsinghua University, Beijing, China
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Abstract

Background: Full-thickness macular hole (FTMH) is a vitreoretinal condition affecting the foveal center that causes central vision loss and metamorphopsia. Despite high surgical success in achieving closure, functional visual recovery remains unpredictable. Identifying reliable optical coherence tomography (OCT) biomarkers that predict postoperative outcomes could improve patient counselling and surgical decision-making. Objective: To systematically evaluate the predictive value of baseline structural OCT biomarkers for visual acuity (VA) outcomes at 3, 6, 12, and 24 months following FTMH surgery. Methods: We will search PubMed, EMBASE, Cochrane Library, and Web of Science databases from inception for studies evaluating baseline OCT parameters as predictors of postoperative VA outcomes following FTMH surgery, with minimum follow-up of 3 months. Data will be synthesized using random-effects meta-analyses. The certainty of evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Conclusions: This systematic review will synthesize current evidence on OCT biomarkers’ predictive value for FTMH surgical outcomes. The findings will clarify their clinical utility and may inform individualized prognostic counselling and surgical decision-making, including which patients are most likely to benefit from surgery and which surgical techniques may be most effective given specific OCT profiles.

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Cite

BibTeXRIS
BibTeX
@article{khademioore2026ophthoevidence,
  title = {{OphthoEvidence report: Baseline structural optical coherence tomography biomarkers as predictors of visual outcomes following full-thickness macular hole surgery: A systematic review and meta-analysis protocol}},
  author = {Sahar Khademioore and João Pedro Lima and Dena Zeraatkar and Sadia Mahmood and Sara Khademioureh and Charles C. Wykoff and Peter K. Kaiser and Tien-Yin Wong and Jiayuan Cheng and Mengda Li and Varun Chaudhary},
  journal = {PLOS One},
  year = {2026},
  month = sep,
  doi = {10.1371/journal.pone.0359108},
  url = {https://doi.org/10.1371/journal.pone.0359108},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - OphthoEvidence report: Baseline structural optical coherence tomography biomarkers as predictors of visual outcomes following full-thickness macular hole surgery: A systematic review and meta-analysis protocol
AU  - Sahar Khademioore
AU  - João Pedro Lima
AU  - Dena Zeraatkar
AU  - Sadia Mahmood
AU  - Sara Khademioureh
AU  - Charles C. Wykoff
AU  - Peter K. Kaiser
AU  - Tien-Yin Wong
AU  - Jiayuan Cheng
AU  - Mengda Li
AU  - Varun Chaudhary
PY  - 2026
DA  - 2026/09/30
JO  - PLOS One
DO  - 10.1371/journal.pone.0359108
UR  - https://doi.org/10.1371/journal.pone.0359108
AB  - Background: Full-thickness macular hole (FTMH) is a vitreoretinal condition affecting the foveal center that causes central vision loss and metamorphopsia. Despite high surgical success in achieving closure, functional visual recovery remains unpredictable. Identifying reliable optical coherence tomography (OCT) biomarkers that predict postoperative outcomes could improve patient counselling and surgical decision-making. Objective: To systematically evaluate the predictive value of baseline structural OCT biomarkers for visual acuity (VA) outcomes at 3, 6, 12, and 24 months following FTMH surgery. Methods: We will search PubMed, EMBASE, Cochrane Library, and Web of Science databases from inception for studies evaluating baseline OCT parameters as predictors of postoperative VA outcomes following FTMH surgery, with minimum follow-up of 3 months. Data will be synthesized using random-effects meta-analyses. The certainty of evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Conclusions: This systematic review will synthesize current evidence on OCT biomarkers’ predictive value for FTMH surgical outcomes. The findings will clarify their clinical utility and may inform individualized prognostic counselling and surgical decision-making, including which patients are most likely to benefit from surgery and which surgical techniques may be most effective given specific OCT profiles.
SN  - 1932-6203
ER  -