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Peer-reviewedCC BYFrontiers in Medicine

Systemic coagulation inflammation index and risk of mortality in peritoneal dialysis patients: a multicenter cohort study

  • Tianying Zhang1
  • Xi Hua2
  • Dong Sun3
  • Xiangcheng Xie4
  • Hong Hu1
  • Wenkai Xia1
  • Wenkai Xia5
5 affiliations
  1. 1Department of Nephrology, Jiangyin People’s Hospital Affiliated to Nantong University, Jiangyin, China
  2. 2Department of Nephrology, Affiliated Hospital of Yangzhou University, Yangzhou First People’s Hospital, Yangzhou, China
  3. 3Department of Nephrology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China
  4. 4Department of Nephrology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
  5. 5Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-University Munich, Munich, Germany
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Abstract

BackgroundThe systemic coagulation inflammation (SCI) index has been investigated as a prognostic marker in several diseases. The aim of this study was to investigate the association of SCI with mortality in patients undergoing peritoneal dialysis (PD).MethodsA total of 324 incident PD patients who initiated treatment between January 2011 and December 2020 were retrospectively analyzed. Patients were stratified using the previously selected outcome-specific SCI cutoffs. Mortality associations were assessed using Cox regression and, for cardiovascular disease (CVD) mortality, competing-risk methods.ResultsPatients were stratified with three groups based on the optimal cutoff value of SCI index. In the primary model (Model 2), lower SCI was associated with increased all-cause mortality (hazard ratio [HR], 9.32; 95% CI, 4.55–19.08, P < 0.001). For CVD mortality, the corresponding HR was 7.03 (95% CI, 3.83–12.92, P < 0.001). SCI areas under the receiver operating characteristic (ROC) curve were 0.681 and 0.688 for all-cause and CVD mortality, respectively. Significant differences in overall survival were observed in older and hypertension population.ConclusionsLower SCI index was associated with higher mortality in this PD cohort. Discrimination was modest, and the data-derived cutoffs require independent validation before clinical use.

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Cite

BibTeXRIS
BibTeX
@article{zhang2026systemic,
  title = {{Systemic coagulation inflammation index and risk of mortality in peritoneal dialysis patients: a multicenter cohort study}},
  author = {Tianying Zhang and Xi Hua and Dong Sun and Xiangcheng Xie and Hong Hu and Wenkai Xia and Wenkai Xia},
  journal = {Frontiers in Medicine},
  year = {2026},
  month = oct,
  doi = {10.3389/fmed.2026.2005361},
  url = {https://doi.org/10.3389/fmed.2026.2005361},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Systemic coagulation inflammation index and risk of mortality in peritoneal dialysis patients: a multicenter cohort study
AU  - Tianying Zhang
AU  - Xi Hua
AU  - Dong Sun
AU  - Xiangcheng Xie
AU  - Hong Hu
AU  - Wenkai Xia
AU  - Wenkai Xia
PY  - 2026
DA  - 2026/10/26
JO  - Frontiers in Medicine
DO  - 10.3389/fmed.2026.2005361
UR  - https://doi.org/10.3389/fmed.2026.2005361
AB  - BackgroundThe systemic coagulation inflammation (SCI) index has been investigated as a prognostic marker in several diseases. The aim of this study was to investigate the association of SCI with mortality in patients undergoing peritoneal dialysis (PD).MethodsA total of 324 incident PD patients who initiated treatment between January 2011 and December 2020 were retrospectively analyzed. Patients were stratified using the previously selected outcome-specific SCI cutoffs. Mortality associations were assessed using Cox regression and, for cardiovascular disease (CVD) mortality, competing-risk methods.ResultsPatients were stratified with three groups based on the optimal cutoff value of SCI index. In the primary model (Model 2), lower SCI was associated with increased all-cause mortality (hazard ratio [HR], 9.32; 95% CI, 4.55–19.08, P < 0.001). For CVD mortality, the corresponding HR was 7.03 (95% CI, 3.83–12.92, P < 0.001). SCI areas under the receiver operating characteristic (ROC) curve were 0.681 and 0.688 for all-cause and CVD mortality, respectively. Significant differences in overall survival were observed in older and hypertension population.ConclusionsLower SCI index was associated with higher mortality in this PD cohort. Discrimination was modest, and the data-derived cutoffs require independent validation before clinical use.
SN  - 2296-858X
ER  -