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Peer-reviewedCC BY 4.0Veterinary and Animal Science

Kinematic changes following concurrent epidural injection with autologous conditioned serum (ACS) and glucocorticoids in dogs with cauda equina syndrome

  • Patrick Blaettler Monnier1
  • Indre Matsuzaki2
  • Nico Gruetter3
  • Julien Troillet4
4 affiliations
  1. 1orthoVET, Fasanenstrasse 13, Frenkendorf, CH-4402, Switzerland
  2. 2Cavia, Iwamoto 537132, Fuji, Shizuoka, 416-0901, Japan
  3. 3FHNW University of Applied Sciences Northwestern Switzerland - Campus Muttenz, Hofackerstrasse 30, 4132 Muttenz, Basel-Land, Switzerland
  4. 4Orthogen Veterinary GmbH, Ernst-Schneider-Platz 1, Düsseldorf, 40212, Germany
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Abstract

Degenerative lumbosacral stenosis (DLSS) causes progressive nerve root compression, leading to cauda equina syndrome (CES) and painful gait impairments in dogs. Epidural co-administration of autologous conditioned serum (ACS) and glucocorticoids (GC) is used as a conservative intervention, but objective outcome data remain lacking. This retrospective exploratory study evaluated whether an inertial measurement unit (IMU)-based kinematic system (LupoGait) could detect gait changes following a single epidural injection of ACS and triamcinolone acetonide in 44 dogs with CES. Nominal post-treatment changes were observed in several hindlimb parameters, including stance phase (HL +0.03, 95% CI 0.005–0.05, p = 0.018), maximum gyroscope amplitude (HL +0.32, 95% CI 0.02 to 0.69, p = 0.032), and variance of the differentiated gyroscope signal (HL +0.10, 95% CI 0.01 to 0.23, p = 0.036). However, no evaluated outcomes remained statistically significant after correction for multiple comparisons. Given the uncontrolled retrospective design, these exploratory findings cannot establish therapeutic efficacy or isolate ACS-specific effects from GC administration. Nevertheless, this study demonstrates the feasibility of IMU-based kinematic analysis for objective longitudinal monitoring in dogs with CES and provides preliminary baseline data for prospective, controlled clinical trials.

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Cite

BibTeXRIS
BibTeX
@article{monnier2026kinematic,
  title = {{Kinematic changes following concurrent epidural injection with autologous conditioned serum (ACS) and glucocorticoids in dogs with cauda equina syndrome}},
  author = {Patrick Blaettler Monnier and Indre Matsuzaki and Nico Gruetter and Julien Troillet},
  journal = {Veterinary and Animal Science},
  year = {2026},
  month = oct,
  doi = {10.1016/j.vas.2026.100911},
  url = {https://doi.org/10.1016/j.vas.2026.100911},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Kinematic changes following concurrent epidural injection with autologous conditioned serum (ACS) and glucocorticoids in dogs with cauda equina syndrome
AU  - Patrick Blaettler Monnier
AU  - Indre Matsuzaki
AU  - Nico Gruetter
AU  - Julien Troillet
PY  - 2026
DA  - 2026/10/20
JO  - Veterinary and Animal Science
DO  - 10.1016/j.vas.2026.100911
UR  - https://doi.org/10.1016/j.vas.2026.100911
AB  - Degenerative lumbosacral stenosis (DLSS) causes progressive nerve root compression, leading to cauda equina syndrome (CES) and painful gait impairments in dogs. Epidural co-administration of autologous conditioned serum (ACS) and glucocorticoids (GC) is used as a conservative intervention, but objective outcome data remain lacking. This retrospective exploratory study evaluated whether an inertial measurement unit (IMU)-based kinematic system (LupoGait) could detect gait changes following a single epidural injection of ACS and triamcinolone acetonide in 44 dogs with CES. Nominal post-treatment changes were observed in several hindlimb parameters, including stance phase (HL +0.03, 95% CI 0.005–0.05, p = 0.018), maximum gyroscope amplitude (HL +0.32, 95% CI 0.02 to 0.69, p = 0.032), and variance of the differentiated gyroscope signal (HL +0.10, 95% CI 0.01 to 0.23, p = 0.036). However, no evaluated outcomes remained statistically significant after correction for multiple comparisons. Given the uncontrolled retrospective design, these exploratory findings cannot establish therapeutic efficacy or isolate ACS-specific effects from GC administration. Nevertheless, this study demonstrates the feasibility of IMU-based kinematic analysis for objective longitudinal monitoring in dogs with CES and provides preliminary baseline data for prospective, controlled clinical trials.
SN  - 2451-943X
ER  -