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Peer-reviewedCC BY 4.0Frontiers in Psychiatry

Adolescent idiopathic scoliosis and comorbid anxiety and depression: advances in psychophysiological interaction mechanisms and integrated interventions

  • Zhaomeng Hou1,2
  • Jiaojiao Wu3
  • Hua Lu1,2
  • Chaoqun Chen1,2
  • Jing Wang1,2
  • Tingliang Han1,2
  1. 1Department of Orthopedics and Traumatology, Yancheng TCM Hospital Affiliated to Nanjing University of Chinese Medicine
  2. 2Department of Orthopedics and Traumatology, Yancheng TCM Hospital
  3. 3Department of Pharmacology, School of Basic Medical Science, Nanjing Medical University
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Abstract

Adolescent Idiopathic Scoliosis (AIS) is a common three-dimensional spinal deformity, and its comorbidity with psychological disorders such as anxiety and depression is increasingly attracting clinical and research attention. This narrative review aims to summarize the epidemiological characteristics of this comorbidity in AIS. It explores the complex underlying psychophysiological interaction mechanisms, including psychosocial stress, chronic pain, body image disturbance, and interconnected neuroendocrine and neuroimmune pathways. Based on this mechanistic understanding, the article further synthesizes and evaluates existing intervention strategies for this comorbid condition, encompassing psychological therapies, pharmacotherapy, physical rehabilitation, and emerging multidisciplinary integrated care models. Finally, the review outlines future research directions, with the goal of providing a theoretical foundation and a comprehensive management framework to improve the holistic physical and mental health outcomes for individuals with AIS.

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Cite

BibTeXRIS
BibTeX
@article{hou2026adolescent,
  title = {{Adolescent idiopathic scoliosis and comorbid anxiety and depression: advances in psychophysiological interaction mechanisms and integrated interventions}},
  author = {Zhaomeng Hou and Jiaojiao Wu and Hua Lu and Chaoqun Chen and Jing Wang and Tingliang Han},
  journal = {Frontiers in Psychiatry},
  year = {2026},
  month = oct,
  doi = {10.3389/fpsyt.2026.1878400},
  url = {https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1878400/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Adolescent idiopathic scoliosis and comorbid anxiety and depression: advances in psychophysiological interaction mechanisms and integrated interventions
AU  - Zhaomeng Hou
AU  - Jiaojiao Wu
AU  - Hua Lu
AU  - Chaoqun Chen
AU  - Jing Wang
AU  - Tingliang Han
PY  - 2026
DA  - 2026/10/28
JO  - Frontiers in Psychiatry
DO  - 10.3389/fpsyt.2026.1878400
UR  - https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1878400/full
AB  - Adolescent Idiopathic Scoliosis (AIS) is a common three-dimensional spinal deformity, and its comorbidity with psychological disorders such as anxiety and depression is increasingly attracting clinical and research attention. This narrative review aims to summarize the epidemiological characteristics of this comorbidity in AIS. It explores the complex underlying psychophysiological interaction mechanisms, including psychosocial stress, chronic pain, body image disturbance, and interconnected neuroendocrine and neuroimmune pathways. Based on this mechanistic understanding, the article further synthesizes and evaluates existing intervention strategies for this comorbid condition, encompassing psychological therapies, pharmacotherapy, physical rehabilitation, and emerging multidisciplinary integrated care models. Finally, the review outlines future research directions, with the goal of providing a theoretical foundation and a comprehensive management framework to improve the holistic physical and mental health outcomes for individuals with AIS.
SN  - 1664-0640
ER  -