Dietary Mixture of Astragalus mongholicus and Codonopsis pilosula Improved the Growth, Immunity, and Lipid Metabolism in the Largemouth Bass Micropterus salmoides
- 1Hubei Key Laboratory of Waterlogging Disaster and Agricultural Use of Wetland Yangtze University Jingzhou 434025 China yangtzeu.edu.cn
- 2College of Life Science Huzhou Normal University Huzhou China
- 3Zhuhai Modern Agriculture Development Center Zhuhai 519000 China
Abstract
This study investigated the effects of dietary supplementation with a mixture of Astragalus mongholicus and Codonopsis pilosula extracts (QSY) on growth, immunity, antioxidant capacity, and lipid metabolism in juvenile largemouth bass (Micropterus salmoides). Fish (initial weight, 10.33 ± 0.07 g) were fed diets containing graded QSY levels (0%, 0.05%, 0.1%, and 0.2%) for 72 days. The results demonstrated that dietary supplementation with 0.1% QSY significantly improved growth performance, feed utilization, and nutrient apparent digestibility. Compared with the control diet, dietary 0.1% QSY enhanced intestinal function by increasing villus length (VL), villus width (VW), wall thickness (WT), and trypsin activity. Dietary 0.1% QSY could enhance immune‐related enzyme activity and upregulate the expression of anti‐inflammatory cytokines, thereby improving the survival rate of largemouth bass following a challenge with Aeromonas veronii. Meanwhile, dietary 0.1% QSY regulated the nuclear factor erythroid 2‐related factor 2/kelch‐like ECH‐associated protein 1 (Nrf2‐Keap1) signaling axis at the transcriptional level, hence enhancing antioxidant enzyme activities in the liver, intestine, and serum, while reducing liver damage and attenuating lipid peroxidation levels in various tissues. Furthermore, compared with the control group, dietary 0.1% QSY reduced hepatic lipid deposition through regulating lipid metabolism, specifically by promoting fatty acid β‐oxidation while inhibiting lipogenesis. However, 0.2% QSY exhibited adverse effects on the growth and survival rate against Aeromonas veronii challenge, suggesting excessive addition should be avoided. In conclusion, appropriate QSY supplementation (0.1%) effectively enhanced growth, immunity, and disease resistance in M. salmoides, supporting its potential as a functional feed additive in aquaculture.
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BibTeX
@article{huang2026dietary,
title = {{Dietary Mixture of Astragalus mongholicus and Codonopsis pilosula Improved the Growth, Immunity, and Lipid Metabolism in the Largemouth Bass Micropterus salmoides}},
author = {Qincheng Huang and Wen Hu and Kai Luo and Weihua Gao and Chenglong Wu and Bin Yin and Fuxian Zhang and Chang Ye and Yongbo Wang},
journal = {Aquaculture Nutrition},
year = {2026},
month = nov,
doi = {10.1155/anu/2780291},
url = {https://doi.org/10.1155/anu/2780291},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Dietary Mixture of Astragalus mongholicus and Codonopsis pilosula Improved the Growth, Immunity, and Lipid Metabolism in the Largemouth Bass Micropterus salmoides
AU - Qincheng Huang
AU - Wen Hu
AU - Kai Luo
AU - Weihua Gao
AU - Chenglong Wu
AU - Bin Yin
AU - Fuxian Zhang
AU - Chang Ye
AU - Yongbo Wang
PY - 2026
DA - 2026/11/02
JO - Aquaculture Nutrition
DO - 10.1155/anu/2780291
UR - https://doi.org/10.1155/anu/2780291
AB - This study investigated the effects of dietary supplementation with a mixture of Astragalus mongholicus and Codonopsis pilosula extracts (QSY) on growth, immunity, antioxidant capacity, and lipid metabolism in juvenile largemouth bass (Micropterus salmoides). Fish (initial weight, 10.33 ± 0.07 g) were fed diets containing graded QSY levels (0%, 0.05%, 0.1%, and 0.2%) for 72 days. The results demonstrated that dietary supplementation with 0.1% QSY significantly improved growth performance, feed utilization, and nutrient apparent digestibility. Compared with the control diet, dietary 0.1% QSY enhanced intestinal function by increasing villus length (VL), villus width (VW), wall thickness (WT), and trypsin activity. Dietary 0.1% QSY could enhance immune‐related enzyme activity and upregulate the expression of anti‐inflammatory cytokines, thereby improving the survival rate of largemouth bass following a challenge with Aeromonas veronii. Meanwhile, dietary 0.1% QSY regulated the nuclear factor erythroid 2‐related factor 2/kelch‐like ECH‐associated protein 1 (Nrf2‐Keap1) signaling axis at the transcriptional level, hence enhancing antioxidant enzyme activities in the liver, intestine, and serum, while reducing liver damage and attenuating lipid peroxidation levels in various tissues. Furthermore, compared with the control group, dietary 0.1% QSY reduced hepatic lipid deposition through regulating lipid metabolism, specifically by promoting fatty acid β‐oxidation while inhibiting lipogenesis. However, 0.2% QSY exhibited adverse effects on the growth and survival rate against Aeromonas veronii challenge, suggesting excessive addition should be avoided. In conclusion, appropriate QSY supplementation (0.1%) effectively enhanced growth, immunity, and disease resistance in M. salmoides, supporting its potential as a functional feed additive in aquaculture.
SN - 1353-5773
SN - 1365-2095
ER -