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Peer-reviewedCC BY-NC 4.0Rare Tumors

Extragastrointestinal stromal tumor involving the adrenal region: A rare case report

  • Mei-Hua Cheng1
  • Chung-An Wang2
  • Yun-Hui Wang3
  • Wei-Jie Wang4,5
5 affiliations
  1. 1Department of Rehabilitation, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan
  2. 2Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei, Taiwan
  3. 3Department of Dentistry, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan
  4. 4Division of Nephrology, Department of Internal Medicine, Lo-Sheng Hospital, Ministry of Health and Welfare, New Taipei, Taiwan
  5. 5Department of Biomedical Engineering, Chung Yuan Christian University, Chungli, Taiwan
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Abstract

Adrenal masses are increasingly detected due to advanced imaging modalities, yet their differential diagnoses remain broad and challenging. Extragastrointestinal stromal tumors (EGISTs) are rare mesenchymal tumors sharing histologic and immunophenotypic features with GISTs but occurring outside the gastrointestinal (GI) tract. EGISTs involving the adrenal region are exceptionally rare, with only five cases previously reported. In this case report, we present the sixth documented case, involving a male patient in his early 60s who presented with acute abdominal pain and a nonfunctioning retroperitoneal mass abutting the adrenal gland. Surgical resection and histopathological analysis confirmed a GIST with cluster of differentiation 117 (CD117) and Discovered on GIST-1 (DOG1) positivity. The patient received adjuvant imatinib and remained recurrence-free at two-year follow-up. This case highlights the diagnostic complexity of EGISTs involving the adrenal region and emphasizes the role of immunohistochemistry and surgical management. While early outcomes appear favorable, the rarity and limited follow-up data call for cautious interpretation and continued reporting to better define the prognosis and optimal treatment strategies.

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Cite

BibTeXRIS
BibTeX
@article{cheng2026extragastrointestinal,
  title = {{Extragastrointestinal stromal tumor involving the adrenal region: A rare case report}},
  author = {Mei-Hua Cheng and Chung-An Wang and Yun-Hui Wang and Wei-Jie Wang},
  journal = {Rare Tumors},
  year = {2026},
  month = sep,
  doi = {10.1177/20363613261490150},
  url = {https://doi.org/10.1177/20363613261490150},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Extragastrointestinal stromal tumor involving the adrenal region: A rare case report
AU  - Mei-Hua Cheng
AU  - Chung-An Wang
AU  - Yun-Hui Wang
AU  - Wei-Jie Wang
PY  - 2026
DA  - 2026/09/15
JO  - Rare Tumors
DO  - 10.1177/20363613261490150
UR  - https://doi.org/10.1177/20363613261490150
AB  - Adrenal masses are increasingly detected due to advanced imaging modalities, yet their differential diagnoses remain broad and challenging. Extragastrointestinal stromal tumors (EGISTs) are rare mesenchymal tumors sharing histologic and immunophenotypic features with GISTs but occurring outside the gastrointestinal (GI) tract. EGISTs involving the adrenal region are exceptionally rare, with only five cases previously reported. In this case report, we present the sixth documented case, involving a male patient in his early 60s who presented with acute abdominal pain and a nonfunctioning retroperitoneal mass abutting the adrenal gland. Surgical resection and histopathological analysis confirmed a GIST with cluster of differentiation 117 (CD117) and Discovered on GIST-1 (DOG1) positivity. The patient received adjuvant imatinib and remained recurrence-free at two-year follow-up. This case highlights the diagnostic complexity of EGISTs involving the adrenal region and emphasizes the role of immunohistochemistry and surgical management. While early outcomes appear favorable, the rarity and limited follow-up data call for cautious interpretation and continued reporting to better define the prognosis and optimal treatment strategies.
SN  - 2036-3605
SN  - 2036-3613
ER  -