Ulcerative Pancreatic Panniculitis Complicated by Secondary Infection and Delayed Wound Healing in a Patient Undergoing Haemodialysis.
4 affiliations
- 1Division of General Internal Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
- 2Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.
- 3Center for Promoting Education, Kobe University Graduate School of Medicine, Kobe, Japan.
- 4Division of Medical and Health Policy Science, Department of Future Social Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Abstract
Introduction
Pancreatic panniculitis is a rare cutaneous manifestation of pancreatic disease.Case description
A 75-year-old man on maintenance haemodialysis with a history of IgG4-related autoimmune pancreatitis presented with painful subcutaneous nodules on the lower extremities and a purulent leg ulcer. Elevated pancreatic enzyme levels and imaging findings suggested an exacerbation of chronic pancreatitis. Histopathological examination of a skin biopsy revealed lobular panniculitis with fat necrosis and ghost-like adipocytes, confirming the diagnosis of pancreatic panniculitis. Subcutaneous nodules regressed with conservative treatment for pancreatitis; however, the ulcer became secondarily infected and showed delayed wound healing.Discussion
In patients undergoing haemodialysis, susceptibility to infection and impaired wound healing may complicate the course of ulcerative pancreatic panniculitis.Conclusion
This case highlights the importance of early recognition of pancreatic panniculitis because secondary infection and delayed wound healing may complicate its clinical course in patients receiving maintenance haemodialysis.Learning points
Pancreatic panniculitis should be considered in patients with painful subcutaneous nodules, even in the absence of abdominal symptoms.Histopathological examination is essential for the diagnosis of pancreatic panniculitis.Ulcerative pancreatic panniculitis may be complicated by secondary infection and delayed wound healing in patients undergoing maintenance haemodialysis.
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BibTeX
@article{nakahara2026ulcerative,
title = {{Ulcerative Pancreatic Panniculitis Complicated by Secondary Infection and Delayed Wound Healing in a Patient Undergoing Haemodialysis.}},
author = {Kodai Nakahara and Mitsumasa Okano and Ryusuke Ono and Ken Goda and Yohei Kanzawa and Kazunori Otsui and Kazuhiko Sakaguchi},
journal = {European journal of case reports in internal medicine},
year = {2026},
month = oct,
doi = {10.12890/2026_007426},
url = {https://europepmc.org/article/MED/43011686},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Ulcerative Pancreatic Panniculitis Complicated by Secondary Infection and Delayed Wound Healing in a Patient Undergoing Haemodialysis.
AU - Kodai Nakahara
AU - Mitsumasa Okano
AU - Ryusuke Ono
AU - Ken Goda
AU - Yohei Kanzawa
AU - Kazunori Otsui
AU - Kazuhiko Sakaguchi
PY - 2026
DA - 2026/10/14
JO - European journal of case reports in internal medicine
DO - 10.12890/2026_007426
UR - https://europepmc.org/article/MED/43011686
AB - Introduction Pancreatic panniculitis is a rare cutaneous manifestation of pancreatic disease.Case description A 75-year-old man on maintenance haemodialysis with a history of IgG4-related autoimmune pancreatitis presented with painful subcutaneous nodules on the lower extremities and a purulent leg ulcer. Elevated pancreatic enzyme levels and imaging findings suggested an exacerbation of chronic pancreatitis. Histopathological examination of a skin biopsy revealed lobular panniculitis with fat necrosis and ghost-like adipocytes, confirming the diagnosis of pancreatic panniculitis. Subcutaneous nodules regressed with conservative treatment for pancreatitis; however, the ulcer became secondarily infected and showed delayed wound healing.Discussion In patients undergoing haemodialysis, susceptibility to infection and impaired wound healing may complicate the course of ulcerative pancreatic panniculitis.Conclusion This case highlights the importance of early recognition of pancreatic panniculitis because secondary infection and delayed wound healing may complicate its clinical course in patients receiving maintenance haemodialysis.Learning points Pancreatic panniculitis should be considered in patients with painful subcutaneous nodules, even in the absence of abdominal symptoms.Histopathological examination is essential for the diagnosis of pancreatic panniculitis.Ulcerative pancreatic panniculitis may be complicated by secondary infection and delayed wound healing in patients undergoing maintenance haemodialysis.
SN - 2284-2594
ER -