Inorganic-Ion-Stabilized Au Nanoparticles Supported on SiO2: Synthesis, Physicochemical Characterization, and Proof-of-Concept Raman Response Toward Methylene Blue
9 affiliations
- 1Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, Av. San Rafael Atlixco 186, Col. Vicentina, México City 09340, Mexico
- 2Departamento de Física, Universidad Autónoma Metropolitana-Iztapalapa, Av. San Rafael Atlixco 186, Col. Vicentina, México City 09340, Mexico
- 3Departamento de Química Inorgánica, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, México City 04510, Mexico
- 4Biotecnología Médica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, Av. Normalistas 800, Colinas de La Normal, Guadalajara 44270, Mexico
- 5Departamento de Ingeniería Eléctrica, Universidad Autónoma Metropolitana-Iztapalapa, Av. San Rafael Atlixco 186, Col. Vicentina, México City 09340, Mexico
- 6División de Ingeniería Mecánica e Industrial, Facultad de Ingeniería, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, México City 04510, Mexico
- 7Departamento de Ingeniería de Procesos e Hidráulica, Universidad Autónoma Metropolitana, México City 04510, Mexico
- 8Instituto Nacional de Investigaciones Nucleares, Car. Méx.-Tol. s/n, La Marquesa, Ocoyoacac 52750, Mexico
- 9Centro de Nanociencias y Micro y Nanotecnologías (CNMN) del Instituto Politécnico Nacional, Av. Luis Enrique Erro s/n, Nueva Industrial Vallejo, Gustavo A. Madero, México City 07700, Mexico
Abstract
Silica nanostructures are attractive platforms for hybrid nanomaterials because of their chemical stability and versatile surface functionalization. Here, spherical SiO2 nanoparticles were synthesized by a modified Stöber method, functionalized with (3-aminopropyl)triethoxysilane (APTES), and decorated with gold nanoparticles (AuNPs) formed using an inorganic stabilization strategy involving OH− and Cl− ions, without conventional organic AuNP capping agents. Complementary characterization by Fourier-transform infrared spectroscopy (FTIR), ultraviolet–visible diffuse reflectance spectroscopy (UV–VIS DRS), X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) supported the sequential surface modification and formation of the SiO2–APTES–AuNPs hybrid material. TEM yielded average diameters of 100.81 ± 1.74 nm for SiO2 nanoparticles (n = 50) and 2.00 ± 0.31 nm for supported AuNPs (n = 80). Methylene blue (MB) was subsequently used for a proof-of-concept Raman evaluation. At 10−3 and 10−4 M MB, relative Raman signal-amplification ratios of approximately 7.5 and 3.5, respectively, were obtained from the integrated response near 1620 cm−1; these values are not conventional surface-enhanced Raman scattering (SERS) enhancement factors. At 10−6 M, a fluorescence-like background was observed without establishing metal-enhanced fluorescence. Density functional theory calculations using an Au32 cluster provided qualitative insight into local S···Au and π···Au interactions. Overall, these results establish an inorganic SiO2-AuNPs as a physicochemically characterized hybrid nanomaterial prepared through an inorganic AuNP-stabilization strategy and support its further investigation in Raman-based applications.
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BibTeX
@article{tellez2026inorganicionstabilized,
title = {{Inorganic-Ion-Stabilized Au Nanoparticles Supported on SiO2: Synthesis, Physicochemical Characterization, and Proof-of-Concept Raman Response Toward Methylene Blue}},
author = {Jorge Luis Mendoza Tellez and Omar E. Uribe-Juárez and Bruno Landeros-Rivera and Alba Adriana Vallejo-Cardona and Diana M. Osorio-Londoño and Federico González García and Francisco Tzompantzi and Raúl Pérez-Hernández and Rebeca Sosa Fonseca and Luis Alberto Moreno Ruiz and Ana María Soto-Estada and Iris N. Serratos},
journal = {Nanomaterials (Basel, Switzerland)},
year = {2026},
month = oct,
doi = {10.3390/nano16191243},
url = {https://europepmc.org/article/PMC/PMC13667054},
note = {CC BY},
}
RIS
TY - JOUR
TI - Inorganic-Ion-Stabilized Au Nanoparticles Supported on SiO2: Synthesis, Physicochemical Characterization, and Proof-of-Concept Raman Response Toward Methylene Blue
AU - Jorge Luis Mendoza Tellez
AU - Omar E. Uribe-Juárez
AU - Bruno Landeros-Rivera
AU - Alba Adriana Vallejo-Cardona
AU - Diana M. Osorio-Londoño
AU - Federico González García
AU - Francisco Tzompantzi
AU - Raúl Pérez-Hernández
AU - Rebeca Sosa Fonseca
AU - Luis Alberto Moreno Ruiz
AU - Ana María Soto-Estada
AU - Iris N. Serratos
PY - 2026
DA - 2026/10/01
JO - Nanomaterials (Basel, Switzerland)
DO - 10.3390/nano16191243
UR - https://europepmc.org/article/PMC/PMC13667054
AB - Silica nanostructures are attractive platforms for hybrid nanomaterials because of their chemical stability and versatile surface functionalization. Here, spherical SiO2 nanoparticles were synthesized by a modified Stöber method, functionalized with (3-aminopropyl)triethoxysilane (APTES), and decorated with gold nanoparticles (AuNPs) formed using an inorganic stabilization strategy involving OH− and Cl− ions, without conventional organic AuNP capping agents. Complementary characterization by Fourier-transform infrared spectroscopy (FTIR), ultraviolet–visible diffuse reflectance spectroscopy (UV–VIS DRS), X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) supported the sequential surface modification and formation of the SiO2–APTES–AuNPs hybrid material. TEM yielded average diameters of 100.81 ± 1.74 nm for SiO2 nanoparticles (n = 50) and 2.00 ± 0.31 nm for supported AuNPs (n = 80). Methylene blue (MB) was subsequently used for a proof-of-concept Raman evaluation. At 10−3 and 10−4 M MB, relative Raman signal-amplification ratios of approximately 7.5 and 3.5, respectively, were obtained from the integrated response near 1620 cm−1; these values are not conventional surface-enhanced Raman scattering (SERS) enhancement factors. At 10−6 M, a fluorescence-like background was observed without establishing metal-enhanced fluorescence. Density functional theory calculations using an Au32 cluster provided qualitative insight into local S···Au and π···Au interactions. Overall, these results establish an inorganic SiO2-AuNPs as a physicochemically characterized hybrid nanomaterial prepared through an inorganic AuNP-stabilization strategy and support its further investigation in Raman-based applications.
SN - 2079-4991
ER -