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Peer-reviewedCC BY 4.0Alzheimer's & Dementia

Brains for dementia research at 18: Commitment to impact the value of human post‐mortem tissue

  • Keeley J. Brookes1
  • Nicola Barnett2
  • Johanna S. Jackson3,4
  • Emma J Kidd5
  • Debra J. Lett6
  • Jillian Madine7
  • Ben Middlehurst7
  • Laura E. Palmer8
  • Laura Parkkinen9
  • Andrew C. Robinson10,11
  • Rebecca Sims12
  • Lindsey Sinclair13
7 more authors
  • Alexandra Stolzing14
  • Philip Tinkler10
  • Claire Troakes15
  • Lauren Walker16,17
  • The BDR Collaborative
  • Alan Thomas2
  • Patrick G. Kehoe8,18
18 affiliations
  1. 1Biosciences Nottingham Trent University Nottingham UK
  2. 2Faculty of Medical Sciences Newcastle University Newcastle UK
  3. 3UK Dementia Research Institute Imperial College London London UK
  4. 4Department of Brain Sciences Imperial College London London UK
  5. 5School of Pharmacy and Pharmaceutical Sciences Cardiff University Cardiff UK
  6. 6Translational and Clinical Research Institute Newcastle University Newcastle upon Tyne UK
  7. 7Institute of Systems, Integrative and Molecular Biology University of Liverpool Liverpool UK
  8. 8South West Dementia Brain Bank University of Bristol Bristol UK
  9. 9The Oxford Brain Bank, Nuffield Department of Clinical Neurosciences University of Oxford Oxford UK
  10. 10Faculty of Biology, Medicine and Health, School of Biological Sciences, Division of Neuroscience The University of Manchester Manchester UK
  11. 11Geoffrey Jefferson Brain Research Centre The University of Manchester Manchester UK
  12. 12Division of Psychological Medicine and Clinical Neuroscience, School of Medicine Cardiff University Cardiff UK
  13. 13Department of Psychiatry University of Southampton Southampton UK
  14. 14Centre for Biological Engineering, Wolfson School of Mechanical, Electrical and Manufacturing Engineering Loughborough University Loughborough UK
  15. 15London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience King's College London London UK
  16. 16School of Health & Life Sciences Teesside University Middlesbrough UK
  17. 17Biomedical Research Centre Newcastle University Newcastle UK
  18. 18School of Psychology and Neuroscience, Faculty of Health and Life Sciences University of Bristol Bristol UK
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Abstract

The Brains for Dementia Research (BDR) project was established to provide high quality, neuropathologically characterized post‐mortem brain tissue from a cohort of participants longitudinally assessed for outcomes that are relevant for research in relation to dementia. From its origins in 2008, over 3200 individuals with and without dementia consented to participate in the project and to donate their brains after death. Now, 18 years later over half of these pledges have been collected. Here we celebrate the BDR project and provide an update on its contributions to the field of dementia research thus far, and the future promise of maximizing benefit from this endeavor with the conception of the “BDR Collaborative”. The BDR Collaborative seeks to align and intersect data generated on this cohort and to accelerate advances in our understanding of neurodegeneration.

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Cite

BibTeXRIS
BibTeX
@article{brookes2026brains,
  title = {{Brains for dementia research at 18: Commitment to impact the value of human post‐mortem tissue}},
  author = {Keeley J. Brookes and Nicola Barnett and Johanna S. Jackson and Emma J Kidd and Debra J. Lett and Jillian Madine and Ben Middlehurst and Laura E. Palmer and Laura Parkkinen and Andrew C. Robinson and Rebecca Sims and Lindsey Sinclair and Alexandra Stolzing and Philip Tinkler and Claire Troakes and Lauren Walker and The BDR Collaborative and Alan Thomas and Patrick G. Kehoe},
  journal = {Alzheimer's \& Dementia},
  year = {2026},
  month = oct,
  doi = {10.1002/alz.71956},
  url = {https://doi.org/10.1002/alz.71956},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Brains for dementia research at 18: Commitment to impact the value of human post‐mortem tissue
AU  - Keeley J. Brookes
AU  - Nicola Barnett
AU  - Johanna S. Jackson
AU  - Emma J Kidd
AU  - Debra J. Lett
AU  - Jillian Madine
AU  - Ben Middlehurst
AU  - Laura E. Palmer
AU  - Laura Parkkinen
AU  - Andrew C. Robinson
AU  - Rebecca Sims
AU  - Lindsey Sinclair
AU  - Alexandra Stolzing
AU  - Philip Tinkler
AU  - Claire Troakes
AU  - Lauren Walker
AU  - The BDR Collaborative
AU  - Alan Thomas
AU  - Patrick G. Kehoe
PY  - 2026
DA  - 2026/10/26
JO  - Alzheimer's & Dementia
DO  - 10.1002/alz.71956
UR  - https://doi.org/10.1002/alz.71956
AB  - The Brains for Dementia Research (BDR) project was established to provide high quality, neuropathologically characterized post‐mortem brain tissue from a cohort of participants longitudinally assessed for outcomes that are relevant for research in relation to dementia. From its origins in 2008, over 3200 individuals with and without dementia consented to participate in the project and to donate their brains after death. Now, 18 years later over half of these pledges have been collected. Here we celebrate the BDR project and provide an update on its contributions to the field of dementia research thus far, and the future promise of maximizing benefit from this endeavor with the conception of the “BDR Collaborative”. The BDR Collaborative seeks to align and intersect data generated on this cohort and to accelerate advances in our understanding of neurodegeneration.
SN  - 1552-5260
SN  - 1552-5279
ER  -