Peer-reviewedCC BYThe Lancet Regional Health - Europe
PFMG2025–integrating genomic medicine into the national healthcare system in France
Abstract
Integrating genomic medicine into healthcare systems is a health policy challenge that requires continuously transferring scientific advances into clinics and ensuring equal access for patients. France was one of the first countries to integrate genome sequencing into clinical practice at a nationwide level, with the ambition to provide more accurate diagnostics and personalized treatments. Since 2016, the French government has invested €239M in the 2025 French Genomic Medicine Initiative (PFMG2025) which has so far focused on patients with rare diseases (RD), cancer genetic predisposition (CGP) and cancers. PFMG2025 has addressed numerous challenges to set up an operational organizational framework. As of December the 31st 2023, 12,737 results were returned to prescribers for RD/CGP patients (median delivery time: 202 days, diagnostic yield: 30.6%) and 3109 for cancer patients (median delivery time: 45 days). PFMG2025's future priorities encompass ensuring economic sustainability, strengthening links with research, empowering patients and practitioners, and fostering collaborations with European partners. Funding: As of December the 31st 2023, €239M have been invested by the French government.
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BibTeX
@article{abadie2026pfmg2025integrating,
title = {{PFMG2025–integrating genomic medicine into the national healthcare system in France}},
author = {Caroline Abadie and Aldja Abderrahmane and Ouarda Abdous and Carine Abel and Oanez Ackermann and Cécile Acquaviva and Flavie Ader and Salma Adham and Dalila Adjaoud and Alexandra Afenjar and Nathalie Aladjidi and Anne-Sophie Alary and Frédérique Albarel and Sabrina Albert and Lise Allard and Ingrid Allix and Violaine Alunni and Inês Amado and Cyril Amouroux and Nicolas André and Chloé Angelini and Mathieu Anheim and Ignacio Antolin Sanfelliz and Thomas Aparicio and Chloé Arfeuille and Jean-Benoît Arlet and Lionel Arnaud and Pauline Arnaud and Guilhem Arnold and Tania Attie-Bitach and Marion Aubert-Mucca and Isabelle Audo and Marie-Pierre Audrezet and Maxime Auroux and Céline Auzanneau and Xavier Ayrignac and Ibrahima Ba and Anne Bachelot and Delphine Bacq and Séverine Bacrot and Brigitte Bader-Meunier and Sarah Baer and Stéphanie Baert-Desurmont and Laurence Bal-Theoleyre and Ralyath Balogoun and Philippe Baltzinger and Guillaume Banneau and Claire Bar and Audrey Barbet and Giulia Barcia and Laure Barjhoux and Anne Barlier and Vincent Barlogis and Marc Barritault and Magalie Barth and Aurore Barthod-Malat and Peggy Baudouin-Cornu and Geneviève Baujat and Amandine Baurand and Jacques-Olivier Bay},
journal = {The Lancet Regional Health - Europe},
year = {2026},
month = oct,
doi = {10.1016/j.lanepe.2024.101183},
url = {https://hal.science/hal-05788852v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - PFMG2025–integrating genomic medicine into the national healthcare system in France
AU - Caroline Abadie
AU - Aldja Abderrahmane
AU - Ouarda Abdous
AU - Carine Abel
AU - Oanez Ackermann
AU - Cécile Acquaviva
AU - Flavie Ader
AU - Salma Adham
AU - Dalila Adjaoud
AU - Alexandra Afenjar
AU - Nathalie Aladjidi
AU - Anne-Sophie Alary
AU - Frédérique Albarel
AU - Sabrina Albert
AU - Lise Allard
AU - Ingrid Allix
AU - Violaine Alunni
AU - Inês Amado
AU - Cyril Amouroux
AU - Nicolas André
AU - Chloé Angelini
AU - Mathieu Anheim
AU - Ignacio Antolin Sanfelliz
AU - Thomas Aparicio
AU - Chloé Arfeuille
AU - Jean-Benoît Arlet
AU - Lionel Arnaud
AU - Pauline Arnaud
AU - Guilhem Arnold
AU - Tania Attie-Bitach
AU - Marion Aubert-Mucca
AU - Isabelle Audo
AU - Marie-Pierre Audrezet
AU - Maxime Auroux
AU - Céline Auzanneau
AU - Xavier Ayrignac
AU - Ibrahima Ba
AU - Anne Bachelot
AU - Delphine Bacq
AU - Séverine Bacrot
AU - Brigitte Bader-Meunier
AU - Sarah Baer
AU - Stéphanie Baert-Desurmont
AU - Laurence Bal-Theoleyre
AU - Ralyath Balogoun
AU - Philippe Baltzinger
AU - Guillaume Banneau
AU - Claire Bar
AU - Audrey Barbet
AU - Giulia Barcia
AU - Laure Barjhoux
AU - Anne Barlier
AU - Vincent Barlogis
AU - Marc Barritault
AU - Magalie Barth
AU - Aurore Barthod-Malat
AU - Peggy Baudouin-Cornu
AU - Geneviève Baujat
AU - Amandine Baurand
AU - Jacques-Olivier Bay
PY - 2026
DA - 2026/10/09
JO - The Lancet Regional Health - Europe
DO - 10.1016/j.lanepe.2024.101183
UR - https://hal.science/hal-05788852v1
AB - Integrating genomic medicine into healthcare systems is a health policy challenge that requires continuously transferring scientific advances into clinics and ensuring equal access for patients. France was one of the first countries to integrate genome sequencing into clinical practice at a nationwide level, with the ambition to provide more accurate diagnostics and personalized treatments. Since 2016, the French government has invested €239M in the 2025 French Genomic Medicine Initiative (PFMG2025) which has so far focused on patients with rare diseases (RD), cancer genetic predisposition (CGP) and cancers. PFMG2025 has addressed numerous challenges to set up an operational organizational framework. As of December the 31st 2023, 12,737 results were returned to prescribers for RD/CGP patients (median delivery time: 202 days, diagnostic yield: 30.6%) and 3109 for cancer patients (median delivery time: 45 days). PFMG2025's future priorities encompass ensuring economic sustainability, strengthening links with research, empowering patients and practitioners, and fostering collaborations with European partners. Funding: As of December the 31st 2023, €239M have been invested by the French government.
SN - 2666-7762
ER -