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Peer-reviewedCC BY-NC-NDJournal of agricultural and food chemistry

4-Biphenylboronic Acid Exerts Antifungal Activity against Neopestalotiopsis ellipsospora via Dual Targeting of Plasma Membrane Integrity and Cell Wall Biogenesis.

  • Shuangqing Tan1
  • Hongfei Gao2
  • Jianmei Yao3
  • Huifang Liu3
  • Lulu Li3
  • Rongxiu Yin3
  • Yao Chen3
  • Zhiwei Lei1,3,4
  • Wen Yang1,3
4 affiliations
  1. 1College of Tea Science, Guizhou University, Guiyang, Guizhou Province550025, China.
  2. 2College of Agricultural Science, Guizhou University, Guiyang, Guizhou Province550025, China.
  3. 3Guizhou Tea Research Institute, Guizhou Academy of Agricultural Sciences, Guiyang550006, China.
  4. 4Guizhou Key Laboratory of Agricultural Biosecurity, Guiyang550025, China.
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Abstract

Neopestalotiopsis ellipsospora causes tea leaf spots, reducing yield and processed tea quality and resulting in economic losses. This study investigated the antifungal activity and mechanism of 4-biphenylboronic acid using mycelial growth inhibition assays, enzymatic analyses, electron microscopy, and RNA sequencing. The compound showed strong antifungal activity against N. ellipsospora with an EC50 of 10.72 mg/L. Mechanistic analyses indicated that 4-biphenylboronic acid disrupted plasma membrane integrity, impaired membrane bioenergetics and solute transport, and perturbed cell wall homeostasis. Transcriptome profiling further identified downregulation of genes associated with chitin biosynthesis, including plasma membrane H+-ATPase, alkaline ceramidase, G-protein-coupled receptor, and chitin synthase 1. Together, these findings suggest that 4-biphenylboronic acid inhibits N. ellipsospora through the coordinated disruption of mitochondrial energy metabolism, membrane function, and cell wall biogenesis.

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Cite

BibTeXRIS
BibTeX
@article{tan20264biphenylboronic,
  title = {{4-Biphenylboronic Acid Exerts Antifungal Activity against Neopestalotiopsis ellipsospora via Dual Targeting of Plasma Membrane Integrity and Cell Wall Biogenesis.}},
  author = {Shuangqing Tan and Hongfei Gao and Jianmei Yao and Huifang Liu and Lulu Li and Rongxiu Yin and Yao Chen and Zhiwei Lei and Wen Yang},
  journal = {Journal of agricultural and food chemistry},
  year = {2026},
  month = oct,
  doi = {10.1021/acs.jafc.6c12098},
  url = {https://europepmc.org/article/MED/42915823},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - 4-Biphenylboronic Acid Exerts Antifungal Activity against Neopestalotiopsis ellipsospora via Dual Targeting of Plasma Membrane Integrity and Cell Wall Biogenesis.
AU  - Shuangqing Tan
AU  - Hongfei Gao
AU  - Jianmei Yao
AU  - Huifang Liu
AU  - Lulu Li
AU  - Rongxiu Yin
AU  - Yao Chen
AU  - Zhiwei Lei
AU  - Wen Yang
PY  - 2026
DA  - 2026/10/01
JO  - Journal of agricultural and food chemistry
DO  - 10.1021/acs.jafc.6c12098
UR  - https://europepmc.org/article/MED/42915823
AB  - Neopestalotiopsis ellipsospora causes tea leaf spots, reducing yield and processed tea quality and resulting in economic losses. This study investigated the antifungal activity and mechanism of 4-biphenylboronic acid using mycelial growth inhibition assays, enzymatic analyses, electron microscopy, and RNA sequencing. The compound showed strong antifungal activity against N. ellipsospora with an EC50 of 10.72 mg/L. Mechanistic analyses indicated that 4-biphenylboronic acid disrupted plasma membrane integrity, impaired membrane bioenergetics and solute transport, and perturbed cell wall homeostasis. Transcriptome profiling further identified downregulation of genes associated with chitin biosynthesis, including plasma membrane H+-ATPase, alkaline ceramidase, G-protein-coupled receptor, and chitin synthase 1. Together, these findings suggest that 4-biphenylboronic acid inhibits N. ellipsospora through the coordinated disruption of mitochondrial energy metabolism, membrane function, and cell wall biogenesis.
SN  - 0021-8561
SN  - 1520-5118
ER  -