Paraneoplastic podocytopathies with nephrotic syndrome in solid cancers with C-Maf inducing protein expression.
16 affiliations
- 1Service de Physiologie-Explorations Fonctionnelles, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.
- 2Université Paris-Est Créteil, INSERM U955, Institut Mondor de Recherche Biomédicale, Créteil, France.
- 3Service Néphrologie et Transplantation, Hôpitaux Universitaires Henri Mondor, Centre de Référence Maladies rares « Syndrome Néphrotique Idiopathique », Assistance Publique-Hôpitaux de Paris, Créteil, France.
- 4Sorbonne Université, INSERM U1155, Hôpital Tenon-Bâtiment Recherche, Paris, France.
- 5Service d'Anatomie et cytologie pathologiques, Hôpital Tenon, Assistance Publique - Hôpitaux de Paris, Paris, France.
- 6Service de Néphrologie, CHU Amiens Picardie (site Sud), Amiens, France.
- 7Service de Néphrologie, CHU Pontchaillou, Université de Rennes, Rennes, France.
- 8Service de Néphrologie et Transplantation, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.
- 9Service de Néphrologie et Transplantation rénale, Centre Hospitalier Régional Universitaire de Lille, Lille, France.
- 10Service de Médecine Interne, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France.
- 11Service de Néphrologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.
- 12Service de Néphrologie, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicêtre, France.
- 13Université Paris Saclay, INSERM U1184, Le Kremlin-Bicêtre, France.
- 14Service de Néphrologie, Hôpitaux universitaires de Genève, Genève, Switzerland.
- 15Service de Néphrologie, Hôpital Foch, Suresnes, France.
- 16Service de Néphrologie et Dialyse, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, France.
Abstract
Background
The main features of minimal change disease (MCD) and focal segmental glomerulosclerosis associated with solid cancer [paraneoplastic podocytopathy with nephrotic syndrome (PPNS)] remain poorly described.Methods
In this French retrospective study, we followed up patients with PPNS and compared them to a control group with idiopathic nephrotic syndrome (INS). Demographic, clinical, laboratory, and pathological data were collected for both groups. Expression of C-Maf inducing protein (CMIP) was studied on kidney biopsies and tumor samples from PPNS and controls (patients with INS or cancer without nephrotic syndrome).Results
Twenty-one PPNS patients (mean age 68 years, 76% men, 76% MCD) were identified. Baseline biological characteristics in PPNS (median urinary protein to creatinine ratio 0.87 g/mmol, albuminemia 15 g/l, and glomerular filtration rate 48 ml/min/1.73 m²) and INS (0.90 g/mmol, 15.3 g/l, and 60 ml/min/1.73 m², respectively) patients were similar. Complete remission of nephrotic syndrome occurred less frequently in PPNS than in INS (25% vs 74%, P = .008).CMIP was highly detected on podocytes from PPNS and INS, and in tumors from PPNS (13/13 samples, either in tumor cells and/or in lymphocytic infiltrates), but its expression was scarce in tumors not associated with nephrotic syndrome. Immunofluorescence analysis revealed that CMIP overexpression was confined to a CD4⁺ FOXP3⁻PD1⁻ T-cell subpopulation.Conclusions
Initial presentation of PPNS is similar to that of INS but complete remission is less frequent. The tight association between nephrotic syndrome and CMIP expression in tumor cells suggests that CMIP might participate in this paraneoplastic syndrome.
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BibTeX
@article{colin2026paraneoplastic,
title = {{Paraneoplastic podocytopathies with nephrotic syndrome in solid cancers with C-Maf inducing protein expression.}},
author = {Arthur Michon Colin and Shao-Yu Zhang and Vincent Audard and David Buob and Dimitri Titeca-Beauport and Henri Brenier and Evangeline Pillebout and Céline Lebas and Nizar Joher and Damien Sene and Alexandre Karras and Mohamad Zaidan and Sophie De Seigneux and Arwa Jalal Eddine and Dil Sahali and Jean-Jacques Boffa},
journal = {Clinical kidney journal},
year = {2026},
month = oct,
doi = {10.1093/ckj/sfag370},
url = {https://europepmc.org/article/MED/43011595},
note = {CC BY},
}
RIS
TY - JOUR
TI - Paraneoplastic podocytopathies with nephrotic syndrome in solid cancers with C-Maf inducing protein expression.
AU - Arthur Michon Colin
AU - Shao-Yu Zhang
AU - Vincent Audard
AU - David Buob
AU - Dimitri Titeca-Beauport
AU - Henri Brenier
AU - Evangeline Pillebout
AU - Céline Lebas
AU - Nizar Joher
AU - Damien Sene
AU - Alexandre Karras
AU - Mohamad Zaidan
AU - Sophie De Seigneux
AU - Arwa Jalal Eddine
AU - Dil Sahali
AU - Jean-Jacques Boffa
PY - 2026
DA - 2026/10/15
JO - Clinical kidney journal
DO - 10.1093/ckj/sfag370
UR - https://europepmc.org/article/MED/43011595
AB - Background The main features of minimal change disease (MCD) and focal segmental glomerulosclerosis associated with solid cancer [paraneoplastic podocytopathy with nephrotic syndrome (PPNS)] remain poorly described.Methods In this French retrospective study, we followed up patients with PPNS and compared them to a control group with idiopathic nephrotic syndrome (INS). Demographic, clinical, laboratory, and pathological data were collected for both groups. Expression of C-Maf inducing protein (CMIP) was studied on kidney biopsies and tumor samples from PPNS and controls (patients with INS or cancer without nephrotic syndrome).Results Twenty-one PPNS patients (mean age 68 years, 76% men, 76% MCD) were identified. Baseline biological characteristics in PPNS (median urinary protein to creatinine ratio 0.87 g/mmol, albuminemia 15 g/l, and glomerular filtration rate 48 ml/min/1.73 m²) and INS (0.90 g/mmol, 15.3 g/l, and 60 ml/min/1.73 m², respectively) patients were similar. Complete remission of nephrotic syndrome occurred less frequently in PPNS than in INS (25% vs 74%, P = .008).CMIP was highly detected on podocytes from PPNS and INS, and in tumors from PPNS (13/13 samples, either in tumor cells and/or in lymphocytic infiltrates), but its expression was scarce in tumors not associated with nephrotic syndrome. Immunofluorescence analysis revealed that CMIP overexpression was confined to a CD4⁺ FOXP3⁻PD1⁻ T-cell subpopulation.Conclusions Initial presentation of PPNS is similar to that of INS but complete remission is less frequent. The tight association between nephrotic syndrome and CMIP expression in tumor cells suggests that CMIP might participate in this paraneoplastic syndrome.
SN - 2048-8505
SN - 2048-8513
ER -