The astrocytic secretome increases adult hippocampal neurogenesis and spatial memory in health and disease
- 1Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, University of Lausanne
Abstract
INTRODUCTION: Adult hippocampal neurogenesis (AHN) plays an important role in memory and is regulated by astrocytes. Since astrocytic function deteriorates with pathological ageing and Alzheimers disease (AD), we hypothesize that the astrocytic secretome may rescue AHN and cognition. METHODS: We tested the effect of astrocyte-conditioned solution (ACS) on AHN and memory performances in young and aged mice and in two models of AD. RESULTS: ACS increased AHN and improved performance in the object location test in young and aged wild-type mice. In THY-Tau22 mice, a model of tau pathology, ACS restored AHN and cognitive performance. In APP/PS1 mice, a model of amyloid pathology, ACS reduced gliogenesis, and rescued deficits in AHN and spatial memory. In addition, ACS attenuated circulating pro-inflammatory cytokines and the reaction of plaque-associated microglia. DISCUSSION: The astrocytic secretome is a promising, niche-targeted strategy to enhance hippocampal plasticity and memory across ageing and AD.
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BibTeX
@misc{vilademunt2026astrocytic,
title = {{The astrocytic secretome increases adult hippocampal neurogenesis and spatial memory in health and disease}},
author = {M. Vilademunt and C. Carron and F. Casse and K. Richetin and E. Gebara and K. Ginggen and J. Nicolet-dit-Felix and L. Piano-Vieira and N. Toni},
howpublished = {bioRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.26.754656},
url = {https://www.biorxiv.org/content/10.64898/2026.09.26.754656v1},
note = {CC BY-NC},
}
RIS
TY - UNPB
TI - The astrocytic secretome increases adult hippocampal neurogenesis and spatial memory in health and disease
AU - M. Vilademunt
AU - C. Carron
AU - F. Casse
AU - K. Richetin
AU - E. Gebara
AU - K. Ginggen
AU - J. Nicolet-dit-Felix
AU - L. Piano-Vieira
AU - N. Toni
PY - 2026
DA - 2026/09/26
PB - bioRxiv
DO - 10.64898/2026.09.26.754656
UR - https://www.biorxiv.org/content/10.64898/2026.09.26.754656v1
AB - INTRODUCTION: Adult hippocampal neurogenesis (AHN) plays an important role in memory and is regulated by astrocytes. Since astrocytic function deteriorates with pathological ageing and Alzheimers disease (AD), we hypothesize that the astrocytic secretome may rescue AHN and cognition. METHODS: We tested the effect of astrocyte-conditioned solution (ACS) on AHN and memory performances in young and aged mice and in two models of AD. RESULTS: ACS increased AHN and improved performance in the object location test in young and aged wild-type mice. In THY-Tau22 mice, a model of tau pathology, ACS restored AHN and cognitive performance. In APP/PS1 mice, a model of amyloid pathology, ACS reduced gliogenesis, and rescued deficits in AHN and spatial memory. In addition, ACS attenuated circulating pro-inflammatory cytokines and the reaction of plaque-associated microglia. DISCUSSION: The astrocytic secretome is a promising, niche-targeted strategy to enhance hippocampal plasticity and memory across ageing and AD.
ER -