The effect of biphasic cuirass ventilation on peripheral lymphatic function in young adults.
- 1Department of Cardiothoracic Surgery, Copenhagen University Hospital, Copenhagen, Denmark.
- 2Department of Anesthesiology, Centre of Head and Orthopaedics, Copenhagen University Hospital, Copenhagen, Denmark.
Abstract
Positive pressure ventilation increases the intrathoracic pressure and the central venous pressure, impeding venous return to the heart. Likewise, both central and peripheral lymphatic function is haltered during positive pressure ventilation, presenting as a possible explanation for fluid retention and edema in post-operative and intensive care unit patients. We aimed to examine the effects of biphasic cuirass ventilation on the peripheral lymphatic system. Peripheral lymphatic function was examined in twenty healthy, young adults during spontaneous breathing and during biphasic cuirass ventilation. The peripheral lymphatic function was assessed with near-infrared fluorescence imaging, and the microvascular circulation was assessed with strain gauge plethysmography. Mean peripheral lymphatic contraction frequency (mean ± SD) was 1.46 ± 0.73/min at baseline and 1.43 ± 0.76/min during biphasic cuirass ventilation. There was no significant difference (mean difference = 0.03, 95% CI: -0.23-0.29, p = 0.81, n = 19). Capillary filtration rates did not differ between baseline and biphasic cuirass ventilation across all pressure levels (F(1,18) = 1.13, p = 0.30). Likewise, there were no significant differences in isovolumetric pressures (mean difference = -2.61, 95% CI: -8.92-3.71, p = 0.39, n = 15), or capillary filtration coefficients (mean difference = 1.21 × 10⁻⁴, 95% CI: -4,87 × 10⁻⁴ - 7.29 × 10⁻⁴, p = 0.68, n = 19). We observed no changes in peripheral lymphatic activity in awake, healthy, young adults during BCV.
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BibTeX
@article{nilsson2026effect,
title = {{The effect of biphasic cuirass ventilation on peripheral lymphatic function in young adults.}},
author = {C Noah Nilsson and Lene Thorup and Benjamin Kelly and Jakob Friis Schmidt and Michael Seltz and Vibeke Hjortdal},
journal = {Physiological reports},
year = {2026},
month = oct,
doi = {10.14814/phy2.71161},
url = {https://europepmc.org/article/MED/42960475},
note = {CC BY},
}
RIS
TY - JOUR
TI - The effect of biphasic cuirass ventilation on peripheral lymphatic function in young adults.
AU - C Noah Nilsson
AU - Lene Thorup
AU - Benjamin Kelly
AU - Jakob Friis Schmidt
AU - Michael Seltz
AU - Vibeke Hjortdal
PY - 2026
DA - 2026/10/30
JO - Physiological reports
DO - 10.14814/phy2.71161
UR - https://europepmc.org/article/MED/42960475
AB - Positive pressure ventilation increases the intrathoracic pressure and the central venous pressure, impeding venous return to the heart. Likewise, both central and peripheral lymphatic function is haltered during positive pressure ventilation, presenting as a possible explanation for fluid retention and edema in post-operative and intensive care unit patients. We aimed to examine the effects of biphasic cuirass ventilation on the peripheral lymphatic system. Peripheral lymphatic function was examined in twenty healthy, young adults during spontaneous breathing and during biphasic cuirass ventilation. The peripheral lymphatic function was assessed with near-infrared fluorescence imaging, and the microvascular circulation was assessed with strain gauge plethysmography. Mean peripheral lymphatic contraction frequency (mean ± SD) was 1.46 ± 0.73/min at baseline and 1.43 ± 0.76/min during biphasic cuirass ventilation. There was no significant difference (mean difference = 0.03, 95% CI: -0.23-0.29, p = 0.81, n = 19). Capillary filtration rates did not differ between baseline and biphasic cuirass ventilation across all pressure levels (F(1,18) = 1.13, p = 0.30). Likewise, there were no significant differences in isovolumetric pressures (mean difference = -2.61, 95% CI: -8.92-3.71, p = 0.39, n = 15), or capillary filtration coefficients (mean difference = 1.21 × 10⁻⁴, 95% CI: -4,87 × 10⁻⁴ - 7.29 × 10⁻⁴, p = 0.68, n = 19). We observed no changes in peripheral lymphatic activity in awake, healthy, young adults during BCV.
SN - 2051-817X
ER -