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Peer-reviewedCC BY-NC-NDBMC genomics

Interactions between kidney proteins and metabolism in Tibetan sheep at different altitudes.

  • Kejiang Liu1
  • Jiang Zhang1
  • Xueqin Yu2
  • Pengfei Zhao3
  1. 1Gansu Key Laboratory of Biodiversity in Gannan Plateau, Faculty of Chemistry and Life Sciences, Gansu Minzu Normal University, Hezuo, 747000, China.
  2. 2Dunhuang City Animal Husbandry and Veterinary Technology Service Center, Dunhuang, 736200, China.
  3. 3Gansu Key Laboratory of Biodiversity in Gannan Plateau, Faculty of Chemistry and Life Sciences, Gansu Minzu Normal University, Hezuo, 747000, China. [email protected].
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Abstract

When oxygen supply to the kidneys is restricted, it may trigger a series of acid-base imbalances and pathological states, subsequently inducing hypoxic adaptive mechanisms in the kidneys. However, the protein-metabolism interaction mechanisms underlying this process remain unclear. Therefore, this study conducted proteomic and metabolomic analyses on Tibetan sheep kidneys collected at three distinct altitudes (2500 m, 3500 m and 4500 m) to elucidate the protein-metabolism interaction mechanisms during hypoxic adaptation. The results demonstrate a synergistic relationship between proteins and metabolism, revealing dynamic expression patterns. Key DEPs (ALDH2, COX5A, GLUD1, NDUFS2, NDUFS8 and SLC17A1) and key DEMs (Wedelolactone, Cytidine, and 3-hydroxybenzoic acid) primarily participated in the antioxidant defense, anti-inflammatory, and energy supply functions of Tibetan sheep kidney hypoxia adaptation through signaling pathways such as the citrate cycle (TCA cycle) and oxidative phosphorylation. In summary, the adaptive mechanisms to renal hypoxia are not influenced by a single protein or metabolite, but rather are related to the interactions between proteins and metabolites. These interactions may collectively influence the adaptive mechanisms, ensuring that the kidneys maintain normal function in high-altitude environments.

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Cite

BibTeXRIS
BibTeX
@article{liu2026interactions,
  title = {{Interactions between kidney proteins and metabolism in Tibetan sheep at different altitudes.}},
  author = {Kejiang Liu and Jiang Zhang and Xueqin Yu and Pengfei Zhao},
  journal = {BMC genomics},
  year = {2026},
  month = jul,
  doi = {10.1186/s12864-026-13228-2},
  url = {https://europepmc.org/article/MED/42902137},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Interactions between kidney proteins and metabolism in Tibetan sheep at different altitudes.
AU  - Kejiang Liu
AU  - Jiang Zhang
AU  - Xueqin Yu
AU  - Pengfei Zhao
PY  - 2026
DA  - 2026/07/01
JO  - BMC genomics
DO  - 10.1186/s12864-026-13228-2
UR  - https://europepmc.org/article/MED/42902137
AB  - When oxygen supply to the kidneys is restricted, it may trigger a series of acid-base imbalances and pathological states, subsequently inducing hypoxic adaptive mechanisms in the kidneys. However, the protein-metabolism interaction mechanisms underlying this process remain unclear. Therefore, this study conducted proteomic and metabolomic analyses on Tibetan sheep kidneys collected at three distinct altitudes (2500 m, 3500 m and 4500 m) to elucidate the protein-metabolism interaction mechanisms during hypoxic adaptation. The results demonstrate a synergistic relationship between proteins and metabolism, revealing dynamic expression patterns. Key DEPs (ALDH2, COX5A, GLUD1, NDUFS2, NDUFS8 and SLC17A1) and key DEMs (Wedelolactone, Cytidine, and 3-hydroxybenzoic acid) primarily participated in the antioxidant defense, anti-inflammatory, and energy supply functions of Tibetan sheep kidney hypoxia adaptation through signaling pathways such as the citrate cycle (TCA cycle) and oxidative phosphorylation. In summary, the adaptive mechanisms to renal hypoxia are not influenced by a single protein or metabolite, but rather are related to the interactions between proteins and metabolites. These interactions may collectively influence the adaptive mechanisms, ensuring that the kidneys maintain normal function in high-altitude environments.
SN  - 1471-2164
ER  -