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Peer-reviewedCC BY 4.0Molecules

Investigation of the Effects of Kahweol, Flurbiprofen and Co-Administration of Kahweol and Flurbiprofen on Vas Deferens, Testis and Sperm Against Ischemia-Reperfusion Injury Induced by Testicular Torsion and Detorsion in Rats

  • Okan Ali Aksoy1
  • Serdar Moralioğlu2
  • Yagmur Okcay3
  • Berk Alp Goksel1
  • Süheyla Esra Ozkocer4
  • Kemal Tuna Olgac5
  • Bekir Erdeve6
  • Elif Bersu Gul5
  • Berkay Bagci4
  • Sema Kocabiyik7
  • Elif Hilal Vural8
  • Gokce Sevim Ozturk Fincan9
3 more authors
  • Emre Avci7
  • Onur Erdem10
  • Ismail Mert Vural3
10 affiliations
  1. 1Department of Animal Experiments and Research Centre, Gulhane Institute of Health Sciences, University of Health Sciences, Ankara 06010, Türkiye
  2. 2Department of Pediatric Surgery, İstanbul Zeynep Kamil Maternity and Children Diseases Health Training and Research Center, University of Health Sciences, İstanbul 34668, Türkiye
  3. 3Department of Pharmacology, Gulhane Faculty of Pharmacy, University of Health Sciences, Ankara 06010, Türkiye
  4. 4Department of Medical Histology, Faculty of Medicine, Gazi University, Ankara 06500, Türkiye
  5. 5Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Ankara University, Ankara 06070, Türkiye
  6. 6Department of Pediatric Surgery, Faculty of Medicine, Hacettepe University, Ankara 06100, Türkiye
  7. 7Department of Biochemistry, Gulhane Faculty of Pharmacy, University of Health Sciences, Ankara 06010, Türkiye
  8. 8Department of Medical Pharmacology, Faculty of Medicine, Lokman Hekim University, Ankara 06510, Türkiye
  9. 9Department of Medical Pharmacology, Faculty of Medicine, Gazi University, Ankara 06500, Türkiye
  10. 10Deparment of Pharmaceutical Toxicology, Gulhane Faculty of Pharmacy, University of Health Sciences, Ankara 06010, Türkiye
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Abstract

Unilateral testicular torsion causes ischemia–reperfusion (I/R) injury, potentially impairing testicular structure and reproductive function. This study investigated the effects of kahweol, flurbiprofen, and their combination on testicular injury and vas deferens contractility following torsion/detorsion in rats. Eighty male Wistar albino rats were divided into five groups: sham, torsion/detorsion, kahweol, flurbiprofen, and combination. Following 2 h of unilateral testicular torsion, treatments were administered immediately after detorsion and continued for six days. Histopathological, biochemical, spermatological, and isolated organ bath analyses were performed on day 7. Torsion/detorsion caused severe ipsilateral histopathological damage, increased caspase-3 immunoreactivity, and impaired vas deferens contractility. All treatments reduced caspase-3 immunoreactivity but failed to significantly improve histopathological damage. Changes in inflammatory mediators and oxidative stress markers were variable, without consistent evidence of antioxidant protection. Flurbiprofen and combination treatment partially improved noradrenaline-induced contractions, while combined treatment enhanced electrical field stimulation-induced responses in the prostatic vas deferens. Spermatological findings were limited by sample availability and variability. These findings suggest that flurbiprofen, alone or combined with kahweol, may partially improve selected functional outcomes following testicular I/R injury, although substantial structural damage persists.

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Cite

BibTeXRIS
BibTeX
@article{aksoy2026investigation,
  title = {{Investigation of the Effects of Kahweol, Flurbiprofen and Co-Administration of Kahweol and Flurbiprofen on Vas Deferens, Testis and Sperm Against Ischemia-Reperfusion Injury Induced by Testicular Torsion and Detorsion in Rats}},
  author = {Okan Ali Aksoy and Serdar Moralioğlu and Yagmur Okcay and Berk Alp Goksel and Süheyla Esra Ozkocer and Kemal Tuna Olgac and Bekir Erdeve and Elif Bersu Gul and Berkay Bagci and Sema Kocabiyik and Elif Hilal Vural and Gokce Sevim Ozturk Fincan and Emre Avci and Onur Erdem and Ismail Mert Vural},
  journal = {Molecules},
  year = {2026},
  month = oct,
  doi = {10.3390/molecules31213922},
  url = {https://www.mdpi.com/1420-3049/31/21/3922},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Investigation of the Effects of Kahweol, Flurbiprofen and Co-Administration of Kahweol and Flurbiprofen on Vas Deferens, Testis and Sperm Against Ischemia-Reperfusion Injury Induced by Testicular Torsion and Detorsion in Rats
AU  - Okan Ali Aksoy
AU  - Serdar Moralioğlu
AU  - Yagmur Okcay
AU  - Berk Alp Goksel
AU  - Süheyla Esra Ozkocer
AU  - Kemal Tuna Olgac
AU  - Bekir Erdeve
AU  - Elif Bersu Gul
AU  - Berkay Bagci
AU  - Sema Kocabiyik
AU  - Elif Hilal Vural
AU  - Gokce Sevim Ozturk Fincan
AU  - Emre Avci
AU  - Onur Erdem
AU  - Ismail Mert Vural
PY  - 2026
DA  - 2026/10/31
JO  - Molecules
DO  - 10.3390/molecules31213922
UR  - https://www.mdpi.com/1420-3049/31/21/3922
AB  - Unilateral testicular torsion causes ischemia–reperfusion (I/R) injury, potentially impairing testicular structure and reproductive function. This study investigated the effects of kahweol, flurbiprofen, and their combination on testicular injury and vas deferens contractility following torsion/detorsion in rats. Eighty male Wistar albino rats were divided into five groups: sham, torsion/detorsion, kahweol, flurbiprofen, and combination. Following 2 h of unilateral testicular torsion, treatments were administered immediately after detorsion and continued for six days. Histopathological, biochemical, spermatological, and isolated organ bath analyses were performed on day 7. Torsion/detorsion caused severe ipsilateral histopathological damage, increased caspase-3 immunoreactivity, and impaired vas deferens contractility. All treatments reduced caspase-3 immunoreactivity but failed to significantly improve histopathological damage. Changes in inflammatory mediators and oxidative stress markers were variable, without consistent evidence of antioxidant protection. Flurbiprofen and combination treatment partially improved noradrenaline-induced contractions, while combined treatment enhanced electrical field stimulation-induced responses in the prostatic vas deferens. Spermatological findings were limited by sample availability and variability. These findings suggest that flurbiprofen, alone or combined with kahweol, may partially improve selected functional outcomes following testicular I/R injury, although substantial structural damage persists.
SN  - 1420-3049
ER  -