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Peer-reviewedCC BY-NC-ND 4.0BMC Cardiovascular Disorders

The diagnostic value of cardiovascular magnetic resonance in hypertrophic cardiomyopathy

  • Huerxidan Sidike1
  • Yashengjiang Maimaiti2
  • Saimaitikari Abudubari1
  • Biling Liang3
  • Guochao Dai1
  • Maimaitiaili Tuerxun2
  • Taihui Yu3
  • Wenjie Tang1,4
4 affiliations
  1. 1Department of Radiology, The First People’s Hospital of Kashi Prefecture, Kashi, Xinjiang 844000 China
  2. 2Department of Cardiology, The Second People’s Hospital of Kashi Prefecture, Kashi, Xinjiang 844000 China
  3. 3Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510000 China
  4. 4Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, No.600 Tianhe Road, Guangzhou, Guangdong 510630 China
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Abstract

Background: Limited studies compare the clinical applications and diagnostic values of cardiovascular magnetic resonance (CMR) versus echocardiography in individuals with hypertrophic cardiomyopathy (HCM).

Objective: This study was performed to evaluate the diagnostic value of CMR in patients with HCM.

Methods: A retrospective study without prospective follow-up was performed on the data from 100 patients diagnosed with HCM from July 2018 to December 2021. All patients underwent echocardiography, CMR scans, and late gadolinium enhancement (LGE). Various parameters of CMR were measured and compared to those of echocardiography to evaluate the diagnostic value of CMR in the diagnosis of HCM.

Results: CMR classified the patients into 6 major types based on the location of myocardial hypertrophy involvement: ventricular septal HCM (n = 43); apical HCM (n = 30); basal septal HCM (n = 4); mid-ventricular HCM (n = 13); mass‑like HCM (n = 1), and diffuse HCM (n = 9). There were 4 patients with symmetric HCM, 96 with asymmetric HCM, 41 with obstructive HCM, and 59 with non-obstructive HCM. The diagnostic accuracy rate of CMR and echocardiography for HCM was 100% and 61%, respectively, with a missed diagnosis rate of 39% (39/100). LGE showed delayed enhancement, which manifested as patchy or focal enhancement within the hypertrophied myocardium. The delayed enhancement area was limited to the hypertrophied myocardial region. CMR + LGE showed myocardial fibrosis at the apex in 62 patients. Echocardiography alone detected 17 patients apical HCM.

Conclusion: The combination of CMR with clinical symptoms may aid in the diagnosis and classification of HCM, as well as in the characterization of myocardial fibrosis. CMR appears to be superior to echocardiography in detecting missed CMR diagnoses. Further study is required to validate these findings.

Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s12872-026-06332-4.

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Cite

BibTeXRIS
BibTeX
@article{sidike2026diagnostic,
  title = {{The diagnostic value of cardiovascular magnetic resonance in hypertrophic cardiomyopathy}},
  author = {Huerxidan Sidike and Yashengjiang Maimaiti and Saimaitikari Abudubari and Biling Liang and Guochao Dai and Maimaitiaili Tuerxun and Taihui Yu and Wenjie Tang},
  journal = {BMC Cardiovascular Disorders},
  year = {2026},
  month = jul,
  doi = {10.1186/s12872-026-06332-4},
  url = {https://doi.org/10.1186/s12872-026-06332-4},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - The diagnostic value of cardiovascular magnetic resonance in hypertrophic cardiomyopathy
AU  - Huerxidan Sidike
AU  - Yashengjiang Maimaiti
AU  - Saimaitikari Abudubari
AU  - Biling Liang
AU  - Guochao Dai
AU  - Maimaitiaili Tuerxun
AU  - Taihui Yu
AU  - Wenjie Tang
PY  - 2026
DA  - 2026/07/01
JO  - BMC Cardiovascular Disorders
DO  - 10.1186/s12872-026-06332-4
UR  - https://doi.org/10.1186/s12872-026-06332-4
AB  - Background: Limited studies compare the clinical applications and diagnostic values of cardiovascular magnetic resonance (CMR) versus echocardiography in individuals with hypertrophic cardiomyopathy (HCM).  Objective: This study was performed to evaluate the diagnostic value of CMR in patients with HCM.  Methods: A retrospective study without prospective follow-up was performed on the data from 100 patients diagnosed with HCM from July 2018 to December 2021. All patients underwent echocardiography, CMR scans, and late gadolinium enhancement (LGE). Various parameters of CMR were measured and compared to those of echocardiography to evaluate the diagnostic value of CMR in the diagnosis of HCM.  Results: CMR classified the patients into 6 major types based on the location of myocardial hypertrophy involvement: ventricular septal HCM (n = 43); apical HCM (n = 30); basal septal HCM (n = 4); mid-ventricular HCM (n = 13); mass‑like HCM (n = 1), and diffuse HCM (n = 9). There were 4 patients with symmetric HCM, 96 with asymmetric HCM, 41 with obstructive HCM, and 59 with non-obstructive HCM. The diagnostic accuracy rate of CMR and echocardiography for HCM was 100% and 61%, respectively, with a missed diagnosis rate of 39% (39/100). LGE showed delayed enhancement, which manifested as patchy or focal enhancement within the hypertrophied myocardium. The delayed enhancement area was limited to the hypertrophied myocardial region. CMR + LGE showed myocardial fibrosis at the apex in 62 patients. Echocardiography alone detected 17 patients apical HCM.  Conclusion: The combination of CMR with clinical symptoms may aid in the diagnosis and classification of HCM, as well as in the characterization of myocardial fibrosis. CMR appears to be superior to echocardiography in detecting missed CMR diagnoses. Further study is required to validate these findings.  Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s12872-026-06332-4.
SN  - 1471-2261
ER  -