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Peer-reviewedCC BYMovement disorders clinical practice

Wearable Evidence Linking Dyskinesia Burden to Sleep Quality in Parkinson's Disease.

  • Viktoria Azoidou1,2
  • Essa Bhadra2
  • Ellen Camboe1,2
  • Kamalesh C Dey1
  • Alexandra Zirra1,2
  • Kira Rowsell3
  • Corrine Quah3
  • Caroline Budu2
  • Thomas Boyle4
  • David Gallagher2
  • Jonathan P Bestwick1
  • Laura Pérez-Carbonell1,5
2 more authors
  • Alastair J Noyce1,2
  • Cristina Simonet1,3,6
6 affiliations
  1. 1Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
  2. 2Department of Neurology, The Royal London Hospital, Barts Health, London, UK.
  3. 3Neurology Department, Homerton Healthcare NHS Foundation Trust, London, UK.
  4. 4Older Person's Services & GIM Special Interest in Parkinson'' Disease, Royal London Hospital, London, UK.
  5. 5Sleep Disorders Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  6. 6Unidad de Trastornos del Movimiento, Servicio de Neurología, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
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Abstract

Background

Sleep disturbances affect 60-80% of people with Parkinson's disease (PD) and worsen quality of life. Dyskinesia is a common complication of dopaminergic therapy, yet its link to sleep quality is poorly understood.Objectives

To examine whether clinician-rated and objectively measured dyskinesia are associated with sleep quality in PD.Methods

We studied 47 people with PD (median age 68 years; 44.7% women; median disease duration 5 years). Sleep was measured with Pittsburgh Sleep Quality Index (PSQI). Dyskinesia was rated clinically (MDS-UPDRS items 4.1, 4.2) and objectively over 7 days using Parkinson's KinetiGraph (median dyskinesia score; DKS). Regression models adjusted for age, sex, motor severity, levodopa dose, and disease duration.Results

All dyskinesia measures predicted poorer sleep unadjusted. After adjusting for levodopa dose, only DKS remained significant (B = 0.18, P = 0.047). Adding disease duration attenuated this (P = 0.051).Conclusions

Wearable-derived dyskinesia, but not clinician-rated dyskinesia, independently predicted poorer sleep, supporting wearable monitoring in PD.

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Cite

BibTeXRIS
BibTeX
@article{azoidou2026wearable,
  title = {{Wearable Evidence Linking Dyskinesia Burden to Sleep Quality in Parkinson's Disease.}},
  author = {Viktoria Azoidou and Essa Bhadra and Ellen Camboe and Kamalesh C Dey and Alexandra Zirra and Kira Rowsell and Corrine Quah and Caroline Budu and Thomas Boyle and David Gallagher and Jonathan P Bestwick and Laura Pérez-Carbonell and Alastair J Noyce and Cristina Simonet},
  journal = {Movement disorders clinical practice},
  year = {2026},
  month = nov,
  doi = {10.1002/mdc3.70887},
  url = {https://europepmc.org/article/MED/42967816},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Wearable Evidence Linking Dyskinesia Burden to Sleep Quality in Parkinson's Disease.
AU  - Viktoria Azoidou
AU  - Essa Bhadra
AU  - Ellen Camboe
AU  - Kamalesh C Dey
AU  - Alexandra Zirra
AU  - Kira Rowsell
AU  - Corrine Quah
AU  - Caroline Budu
AU  - Thomas Boyle
AU  - David Gallagher
AU  - Jonathan P Bestwick
AU  - Laura Pérez-Carbonell
AU  - Alastair J Noyce
AU  - Cristina Simonet
PY  - 2026
DA  - 2026/11/01
JO  - Movement disorders clinical practice
DO  - 10.1002/mdc3.70887
UR  - https://europepmc.org/article/MED/42967816
AB  - Background  Sleep disturbances affect 60-80% of people with Parkinson's disease (PD) and worsen quality of life. Dyskinesia is a common complication of dopaminergic therapy, yet its link to sleep quality is poorly understood.Objectives  To examine whether clinician-rated and objectively measured dyskinesia are associated with sleep quality in PD.Methods  We studied 47 people with PD (median age 68 years; 44.7% women; median disease duration 5 years). Sleep was measured with Pittsburgh Sleep Quality Index (PSQI). Dyskinesia was rated clinically (MDS-UPDRS items 4.1, 4.2) and objectively over 7 days using Parkinson's KinetiGraph (median dyskinesia score; DKS). Regression models adjusted for age, sex, motor severity, levodopa dose, and disease duration.Results  All dyskinesia measures predicted poorer sleep unadjusted. After adjusting for levodopa dose, only DKS remained significant (B = 0.18, P = 0.047). Adding disease duration attenuated this (P = 0.051).Conclusions  Wearable-derived dyskinesia, but not clinician-rated dyskinesia, independently predicted poorer sleep, supporting wearable monitoring in PD.
SN  - 2330-1619
ER  -