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Peer-reviewedCC BY-NC-NDClinical case reports

Aggressive Hepatic AL Amyloidosis Encountering Therapeutic Frailty: Rapid Organ Reversal With Tailored Daratumumab‐Based Therapy and Low‐Dose Corticosteroids in a Patient With Steroid‐Induced Psychosis

  • R. Ceccarelli1
  • M. Offidani2
  • E. Morsia1,2
  • A. Poloni1,2
  • A. Mandolesi3
  • G. Goteri3
  • M. Valente4
  • A. Ranghino4
  • S. Morè1,2
4 affiliations
  1. 1Department of Clinical and Molecular Sciences Marche Polytechnic University Ancona Italy
  2. 2Hematology Clinic AOU delle Marche Ancona Italy
  3. 3Department of Internal Medicine, Pathological Anatomy Unit AOU of Marche Ancona Italy
  4. 4Nephrology, Dialysis and Renal Transplantation Unit Azienda Ospedaliera Universitaria delle Marche Ancona Italy
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Abstract

Hepatic AL amyloidosis can cause severe cholestasis independent of marrow tumor burden. In patients with absolute contraindications to high‐dose steroids—such as steroid‐induced psychosis—tailored daratumumab regimens with low‐dose corticosteroids can drive rapid, life‐saving organ reversal. However, intensive antimicrobial vigilance remains mandatory.

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Cite

BibTeXRIS
BibTeX
@article{ceccarelli2026aggressive,
  title = {{Aggressive Hepatic AL Amyloidosis Encountering Therapeutic Frailty: Rapid Organ Reversal With Tailored Daratumumab‐Based Therapy and Low‐Dose Corticosteroids in a Patient With Steroid‐Induced Psychosis}},
  author = {R. Ceccarelli and M. Offidani and E. Morsia and A. Poloni and A. Mandolesi and G. Goteri and M. Valente and A. Ranghino and S. Morè},
  journal = {Clinical case reports},
  year = {2026},
  month = oct,
  doi = {10.1002/ccr3.73831},
  url = {https://europepmc.org/article/PMC/PMC13719798},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Aggressive Hepatic AL Amyloidosis Encountering Therapeutic Frailty: Rapid Organ Reversal With Tailored Daratumumab‐Based Therapy and Low‐Dose Corticosteroids in a Patient With Steroid‐Induced Psychosis
AU  - R. Ceccarelli
AU  - M. Offidani
AU  - E. Morsia
AU  - A. Poloni
AU  - A. Mandolesi
AU  - G. Goteri
AU  - M. Valente
AU  - A. Ranghino
AU  - S. Morè
PY  - 2026
DA  - 2026/10/29
JO  - Clinical case reports
DO  - 10.1002/ccr3.73831
UR  - https://europepmc.org/article/PMC/PMC13719798
AB  - Hepatic AL amyloidosis can cause severe cholestasis independent of marrow tumor burden. In patients with absolute contraindications to high‐dose steroids—such as steroid‐induced psychosis—tailored daratumumab regimens with low‐dose corticosteroids can drive rapid, life‐saving organ reversal. However, intensive antimicrobial vigilance remains mandatory.
SN  - 2050-0904
ER  -