Changes in the epidemiological patterns of SARS-CoV-2 in South Korea from 2020 to 2022: indirect evidence for the impact of non-pharmaceutical interventions
4 affiliations
- 1Laboratory of Veterinary Microbiology, College of Veterinary Medicine, Kyungpook National University
- 2Division of Emerging Infectious Diseases, Department of Laboratory Diagnosis and Analysis, Korea Disease Control and Prevention Agency
- 3Department of Microbiology, College of Medicine, Chungbuk National University
- 4Wildlife Health Laboratory, College of Veterinary Medicine, Konkuk University
Abstract
The coronavirus disease 2019 (COVID-19) pandemic has significantly affected global public health since its emergence in late 2019. This study aimed to investigate the temporal and spatial dynamics of SARS-CoV-2 transmission in South Korea from 2020 to 2022, with particular emphasis on the effects of changes in quarantine policy and viral lineage evolution. Using 77,224 high-quality whole-genome sequences, phylogenetic analyses were performed to evaluate lineage introductions, substitution rates, and cryptic transmission patterns across distinct phases of the pandemic. Additionally, Bayesian phylogeographic analyses were conducted to reconstruct transmission patterns within South Korea. The findings revealed a substantial increase in the number of monophyletic clusters following the relaxation of quarantine measures, particularly during the period of Omicron sub-lineage predominance. Phylogeographic reconstructions identified Seoul and Gyeonggi Province as major transmission hubs nationwide. Substitution rate analyses indicated a progressive decline over time, with Omicron sub-lineages exhibiting significantly reduced evolutionary rates compared to earlier variants. A novel recombinant variant was detected; however, it did not result in sustained transmission. These findings provide indirect evidence that non-pharmaceutical interventions were effective in limiting the introduction and spread of novel viruses, although they could not completely prevent outbreaks. The adaptation and strengthening of such control strategies should be considered in preparing for next pandemics.
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BibTeX
@article{lee2026changes,
title = {{Changes in the epidemiological patterns of SARS-CoV-2 in South Korea from 2020 to 2022: indirect evidence for the impact of non-pharmaceutical interventions}},
author = {Dong-Wook Lee and Jeong-Min Kim and Il-Hwan Kim and Jin Sun No and Jeong-Ah Kim and Chae Young Lee and JeeEun Rhee and Da-Won Kim and Ji-Yun Kim and Ye-Jin Lee and Sungsu Youk and Dong-Hun Lee and Eun-Jin Kim and Jung-Hoon Kwon},
journal = {Scientific Reports},
year = {2026},
month = jul,
doi = {10.1038/s41598-026-63537-5},
url = {https://doi.org/10.1038/s41598-026-63537-5},
note = {CC BY},
}
RIS
TY - JOUR
TI - Changes in the epidemiological patterns of SARS-CoV-2 in South Korea from 2020 to 2022: indirect evidence for the impact of non-pharmaceutical interventions
AU - Dong-Wook Lee
AU - Jeong-Min Kim
AU - Il-Hwan Kim
AU - Jin Sun No
AU - Jeong-Ah Kim
AU - Chae Young Lee
AU - JeeEun Rhee
AU - Da-Won Kim
AU - Ji-Yun Kim
AU - Ye-Jin Lee
AU - Sungsu Youk
AU - Dong-Hun Lee
AU - Eun-Jin Kim
AU - Jung-Hoon Kwon
PY - 2026
DA - 2026/07/01
JO - Scientific Reports
DO - 10.1038/s41598-026-63537-5
UR - https://doi.org/10.1038/s41598-026-63537-5
AB - The coronavirus disease 2019 (COVID-19) pandemic has significantly affected global public health since its emergence in late 2019. This study aimed to investigate the temporal and spatial dynamics of SARS-CoV-2 transmission in South Korea from 2020 to 2022, with particular emphasis on the effects of changes in quarantine policy and viral lineage evolution. Using 77,224 high-quality whole-genome sequences, phylogenetic analyses were performed to evaluate lineage introductions, substitution rates, and cryptic transmission patterns across distinct phases of the pandemic. Additionally, Bayesian phylogeographic analyses were conducted to reconstruct transmission patterns within South Korea. The findings revealed a substantial increase in the number of monophyletic clusters following the relaxation of quarantine measures, particularly during the period of Omicron sub-lineage predominance. Phylogeographic reconstructions identified Seoul and Gyeonggi Province as major transmission hubs nationwide. Substitution rate analyses indicated a progressive decline over time, with Omicron sub-lineages exhibiting significantly reduced evolutionary rates compared to earlier variants. A novel recombinant variant was detected; however, it did not result in sustained transmission. These findings provide indirect evidence that non-pharmaceutical interventions were effective in limiting the introduction and spread of novel viruses, although they could not completely prevent outbreaks. The adaptation and strengthening of such control strategies should be considered in preparing for next pandemics.
SN - 2045-2322
ER -