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Peer-reviewedCC BYFoods (Basel, Switzerland)

Effective Extraction and Determination of 3-Nitropropanoic Acid in Sugarcane Samples Based on Magnetic Solid-Phase Extraction Coupled with HPLC-MS/MS.

  • Yaqi Zhang1,2
  • Jing Dai1
  • Yijing Zhao1
  • Aibo Wu2
  • Lijun He3
  • Lei Zheng1
  • Wei Min1
  • Jiang Liang4
  • Na Liu2
  • Lipeng Hao1
4 affiliations
  1. 1Shanghai Pudong New Area Center for Disease Control and Prevention (Shanghai Pudong New Area Health Supervision Institute), Shanghai 200136, China.
  2. 2Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  3. 3School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China.
  4. 4China National Center for Food Safety Risk Assessment, Beijing 100022, China.
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Abstract

To reduce the risk associated with 3-nitropropanoic acid (3-NPA) contamination, an efficient and accurate analytical method for 3-NPA determination in sugarcane samples was established by combining magnetic solid-phase extraction (MSPE) with high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Owing to the hydrogen bonding and hydrophobic interactions, the mixed strong cation exchange (MCX) magnetic adsorbent showed effective extraction ability toward 3-NPA. Only 2 mL of organic solvent was consumed during the MSPE procedure, and the operation time was short (5 min). The limits of detection were 0.02 μg kg⁻¹ for sugarcane juice and 0.04 μg kg⁻¹ for sugarcane. The developed method showed satisfactory spiked relative recoveries (96.9-105.4%) and good precision values (RSD 1.4-9.7%). MCX-MSPE cleanup provided partial mitigation of matrix suppression, with the absolute matrix effect value rising from 39.4% to 57.1%. This study provides an efficient analytical alternative for the determination of 3-NPA in sugarcane samples.

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Cite

BibTeXRIS
BibTeX
@article{zhang2026effective,
  title = {{Effective Extraction and Determination of 3-Nitropropanoic Acid in Sugarcane Samples Based on Magnetic Solid-Phase Extraction Coupled with HPLC-MS/MS.}},
  author = {Yaqi Zhang and Jing Dai and Yijing Zhao and Aibo Wu and Lijun He and Lei Zheng and Wei Min and Jiang Liang and Na Liu and Lipeng Hao},
  journal = {Foods (Basel, Switzerland)},
  year = {2026},
  month = sep,
  doi = {10.3390/foods15193466},
  url = {https://europepmc.org/article/MED/42883573},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Effective Extraction and Determination of 3-Nitropropanoic Acid in Sugarcane Samples Based on Magnetic Solid-Phase Extraction Coupled with HPLC-MS/MS.
AU  - Yaqi Zhang
AU  - Jing Dai
AU  - Yijing Zhao
AU  - Aibo Wu
AU  - Lijun He
AU  - Lei Zheng
AU  - Wei Min
AU  - Jiang Liang
AU  - Na Liu
AU  - Lipeng Hao
PY  - 2026
DA  - 2026/09/28
JO  - Foods (Basel, Switzerland)
DO  - 10.3390/foods15193466
UR  - https://europepmc.org/article/MED/42883573
AB  - To reduce the risk associated with 3-nitropropanoic acid (3-NPA) contamination, an efficient and accurate analytical method for 3-NPA determination in sugarcane samples was established by combining magnetic solid-phase extraction (MSPE) with high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Owing to the hydrogen bonding and hydrophobic interactions, the mixed strong cation exchange (MCX) magnetic adsorbent showed effective extraction ability toward 3-NPA. Only 2 mL of organic solvent was consumed during the MSPE procedure, and the operation time was short (5 min). The limits of detection were 0.02 μg kg⁻¹ for sugarcane juice and 0.04 μg kg⁻¹ for sugarcane. The developed method showed satisfactory spiked relative recoveries (96.9-105.4%) and good precision values (RSD 1.4-9.7%). MCX-MSPE cleanup provided partial mitigation of matrix suppression, with the absolute matrix effect value rising from 39.4% to 57.1%. This study provides an efficient analytical alternative for the determination of 3-NPA in sugarcane samples.
SN  - 2304-8158
ER  -