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Peer-reviewedCC BYInternational Urogynecology Journal

A Global Consensus Conference on Surgical Management of Primary Uterovaginal Prolapse and Lower Urinary Tract Dysfunction: Combining Evidence with Expert Opinion

  • Ankita Gupta1
  • Cara L. Grimes2
  • Gopal Badlani3
  • Maria Augusta Tezelli Bortolini4
  • Anna Rosamilia5
  • Dudley Robinson6
  • Victor W. Νitti7
  • Anne Pelletier Cameron8
  • Jan A. Deprest9
  • Amy Sisson10
  • Yu Hwee Tan11,12
  • Howard Brian Goldman13
19 more authors
  • Geoffrey William Cundiff14
  • Marianna Alperin15,16
  • Amr Sherif El Haraki3
  • Sarah Collins17
  • Aparne Hegde18,19,20,21
  • H Kyaw22
  • Reut Rotem23
  • Lieschen H. Quiroz24
  • Eric R. Sokol25
  • Erin A. Brennand26
  • Katherine Woodburn3
  • Marine Lallemant27
  • Cecile Ferrando28
  • Hugo van Eijndhoven29
  • Jan Filip Baekelandt30
  • Sarah E. Ashmore31
  • Kimberly Sue Kenton17
  • Kaidi Kang32
  • Catherine A. Matthews33
33 affiliations
  1. 1Division of Urogynecology and Reconstructive Pelvic Surgery, University of Louisville Health, Louisville, KY, USA
  2. 2Obstetrics and Gynecology, Albany Medical College, Albany, NY, USA
  3. 3Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Urology, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston Salem, NC, 27101, USA
  4. 4Division of Urogynecology, Department of Obstetrics and Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil
  5. 5Department of Obstetrics and Gynecology, Monash University, Melbourne, Australia
  6. 6Department of Obstetrics and Gynecology, Kings College Hospital, London, UK
  7. 7Department of Urology, University of California, Los Angeles, CA, USA
  8. 8Department of Urology, University of Michigan, Ann Arbor, MI, USA
  9. 9Department of Obstetrics and Gynecology, University of Leuven, Louvain, Belgium
  10. 10Carpenter Library, Wake Forest University School of Medicine, Winston-Salem, NC, USA
  11. 11Gold Coast Health, Gold Coast, QLD, Australia
  12. 12University of Queensland, Brisbane, QLD, Australia
  13. 13Glickman Urologic Institute, Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA
  14. 14Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada
  15. 15Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Urogynecology and Reconstructive Pelvic Surgery, University of California, San Diego, San Diego, CA, USA
  16. 16Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA
  17. 17Division of Urogynecology and Reconstructive Pelvic Surgery, University of Chicago, Chicago, IL, USA
  18. 18Center for Urogynecology and Pelvic Health, Surya Hospital, Mumbai, India
  19. 19Department of Urogynecology, Government Medical College, Cama & Albless Hospital and GT Hospital, Mumbai, India
  20. 20Gleneagles Hospital, Mumbai, India
  21. 21Mitr Hospital, Kharghar, Navi Mumbai, India
  22. 22Griffith University School of Medicine, Queensland, Australia
  23. 23Department of Urogynecology, Cork University Maternity Hospital, Cork, Ireland
  24. 24Department of Obstetrics and Gynecology, University of Oklahoma, Norman, OK, USA
  25. 25Department of Obstetrics and Gynecology, Stanford University, Stanford, CA, USA
  26. 26Department of Obstetrics and Gynecology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
  27. 27Department of Gynecologic Surgery, Lille University Hospital, Lille, France
  28. 28Division of Urogynecology and Reconstructive Pelvic Surgery, University of California, San Diego, San Diego, CA, USA
  29. 29Department of Obstetrics and Gynecology, Isala Hospital, Zwolle, The Netherlands
  30. 30Department of Obstetrics and Gynecology, Imelda Hospital, Bonheiden, Belgium
  31. 31Department of Urology, UCHealth Northern Colorado, Loveland, CO, USA
  32. 32Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, USA
  33. 33Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Urology, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston Salem, NC, 27101, USA. [email protected]
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Abstract

INTRODUCTION AND HYPOTHESIS: This global consensus conference was designed to define best practice for the controversial aspects of primary surgical management of uterovaginal pelvic organ prolapse (U-POP), to identify unanswered clinical questions, and to educate junior researchers on systematic review and meta-analysis methodology. METHODS: Eleven committees were created with geographically diverse representation and tasked with answering pragmatic questions specific to U-POP surgical decision making. A systematic search of MEDLINE, Embase, and ClinicalTrials.gov from 2000 through December 2025 was performed with specific search terms for each committee. Relevant abstracts and full texts were doubly screened and included articles were doubly extracted. Guided by literature, consensus statements were created and assigned high, moderate, and low levels of evidence. Statements with low levels of evidence were presented and voted upon in-person at a consensus conference, hosted by the Department of Urology at Wake Forest University School of Medicine in Winston Salem, NC, USA. RESULTS: Contributions from 154 participants (including 33 junior researchers) from 19 countries led to 29 systematic searches, screening of 51,143 abstracts and 3,869 full-text manuscripts. There were 133 consensus statements presented at the conference; 6 were supported by high-quality, 28 by moderate-quality, and 99 by low-quality or no evidence respectively, and required Delphi process consensus. Among expert opinion statements, 58 were accepted, 32 were rejected, and 9 were eligible for revision. CONCLUSIONS: A total of 92 statements are presented here to guide clinical decision making and best practices in surgical management of primary U-POP.

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Cite

BibTeXRIS
BibTeX
@article{gupta2026global,
  title = {{A Global Consensus Conference on Surgical Management of Primary Uterovaginal Prolapse and Lower Urinary Tract Dysfunction: Combining Evidence with Expert Opinion}},
  author = {Ankita Gupta and Cara L. Grimes and Gopal Badlani and Maria Augusta Tezelli Bortolini and Anna Rosamilia and Dudley Robinson and Victor W. Νitti and Anne Pelletier Cameron and Jan A. Deprest and Amy Sisson and Yu Hwee Tan and Howard Brian Goldman and Geoffrey William Cundiff and Marianna Alperin and Amr Sherif El Haraki and Sarah Collins and Aparne Hegde and H Kyaw and Reut Rotem and Lieschen H. Quiroz and Eric R. Sokol and Erin A. Brennand and Katherine Woodburn and Marine Lallemant and Cecile Ferrando and Hugo van Eijndhoven and Jan Filip Baekelandt and Sarah E. Ashmore and Kimberly Sue Kenton and Kaidi Kang and Catherine A. Matthews},
  journal = {International Urogynecology Journal},
  year = {2026},
  month = jul,
  doi = {10.1007/s00192-026-06758-6},
  url = {https://doi.org/10.1007/s00192-026-06758-6},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - A Global Consensus Conference on Surgical Management of Primary Uterovaginal Prolapse and Lower Urinary Tract Dysfunction: Combining Evidence with Expert Opinion
AU  - Ankita Gupta
AU  - Cara L. Grimes
AU  - Gopal Badlani
AU  - Maria Augusta Tezelli Bortolini
AU  - Anna Rosamilia
AU  - Dudley Robinson
AU  - Victor W. Νitti
AU  - Anne Pelletier Cameron
AU  - Jan A. Deprest
AU  - Amy Sisson
AU  - Yu Hwee Tan
AU  - Howard Brian Goldman
AU  - Geoffrey William Cundiff
AU  - Marianna Alperin
AU  - Amr Sherif El Haraki
AU  - Sarah Collins
AU  - Aparne Hegde
AU  - H Kyaw
AU  - Reut Rotem
AU  - Lieschen H. Quiroz
AU  - Eric R. Sokol
AU  - Erin A. Brennand
AU  - Katherine Woodburn
AU  - Marine Lallemant
AU  - Cecile Ferrando
AU  - Hugo van Eijndhoven
AU  - Jan Filip Baekelandt
AU  - Sarah E. Ashmore
AU  - Kimberly Sue Kenton
AU  - Kaidi Kang
AU  - Catherine A. Matthews
PY  - 2026
DA  - 2026/07/02
JO  - International Urogynecology Journal
DO  - 10.1007/s00192-026-06758-6
UR  - https://doi.org/10.1007/s00192-026-06758-6
AB  - INTRODUCTION AND HYPOTHESIS: This global consensus conference was designed to define best practice for the controversial aspects of primary surgical management of uterovaginal pelvic organ prolapse (U-POP), to identify unanswered clinical questions, and to educate junior researchers on systematic review and meta-analysis methodology. METHODS: Eleven committees were created with geographically diverse representation and tasked with answering pragmatic questions specific to U-POP surgical decision making. A systematic search of MEDLINE, Embase, and ClinicalTrials.gov from 2000 through December 2025 was performed with specific search terms for each committee. Relevant abstracts and full texts were doubly screened and included articles were doubly extracted. Guided by literature, consensus statements were created and assigned high, moderate, and low levels of evidence. Statements with low levels of evidence were presented and voted upon in-person at a consensus conference, hosted by the Department of Urology at Wake Forest University School of Medicine in Winston Salem, NC, USA. RESULTS: Contributions from 154 participants (including 33 junior researchers) from 19 countries led to 29 systematic searches, screening of 51,143 abstracts and 3,869 full-text manuscripts. There were 133 consensus statements presented at the conference; 6 were supported by high-quality, 28 by moderate-quality, and 99 by low-quality or no evidence respectively, and required Delphi process consensus. Among expert opinion statements, 58 were accepted, 32 were rejected, and 9 were eligible for revision. CONCLUSIONS: A total of 92 statements are presented here to guide clinical decision making and best practices in surgical management of primary U-POP.
SN  - 0937-3462
SN  - 1433-3023
ER  -