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Peer-reviewedCC BY-NC-NDLiver international : official journal of the International Association for the Study of the Liver

Excess Liver Fat in Type 2 Diabetes Stratified by Intrapancreatic Fat Deposition: A Meta-Analysis of Dual-Organ MRI Studies.

  • Hyun Hee Sul1
  • Saeed Ahmad2
  • Pojsakorn Danpanichkul3
  • Matheus Souza4
  • Maxim S Petrov5
5 affiliations
  1. 1Department of Internal Medicine, Jersey City Medical Center/Rutgers Health, Jersey City, New Jersey, USA.
  2. 2Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
  3. 3Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
  4. 4Department of Internal Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  5. 5School of Medicine, University of Auckland, Auckland, New Zealand.
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Abstract

Both liver fat content (LFC) and intrapancreatic fat deposition (IPFD) are frequently increased in Type 2 diabetes mellitus (T2DM). We meta-analysed dual-organ MRI studies comparing LFC between individuals with T2DM and non-diabetic controls and explored whether study-level differences in LFC varied according to IPFD burden. Seventeen studies (2142 participants) were included. Individuals with T2DM had significantly higher LFC than non-diabetic controls (standardised mean difference [SMD] 0.89, 95% CI 0.60-1.18). In exploratory subgroup analyses, liver fat excess was larger in studies with mean IPFD ≥ 10% than in those with IPFD < 10% (SMD 1.20 vs. 0.62; p = 0.04), though this finding was not consistently retained in leave-one-out analyses. Alternative IPFD cutoffs yielded directionally similar but non-significant subgroup differences. Study-level differences in IPFD were associated with differences in LFC (β = 0.383, p = 0.006) in univariable meta-regression, but not after BMI adjustment. These findings suggest that higher IPFD is associated with greater liver fat excess in T2DM at the study level. Individual-level analyses are now warranted to clarify this relationship.

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Cite

BibTeXRIS
BibTeX
@article{sul2026excess,
  title = {{Excess Liver Fat in Type 2 Diabetes Stratified by Intrapancreatic Fat Deposition: A Meta-Analysis of Dual-Organ MRI Studies.}},
  author = {Hyun Hee Sul and Saeed Ahmad and Pojsakorn Danpanichkul and Matheus Souza and Maxim S Petrov},
  journal = {Liver international : official journal of the International Association for the Study of the Liver},
  year = {2026},
  month = oct,
  doi = {10.1111/liv.70934},
  url = {https://europepmc.org/article/MED/42897902},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Excess Liver Fat in Type 2 Diabetes Stratified by Intrapancreatic Fat Deposition: A Meta-Analysis of Dual-Organ MRI Studies.
AU  - Hyun Hee Sul
AU  - Saeed Ahmad
AU  - Pojsakorn Danpanichkul
AU  - Matheus Souza
AU  - Maxim S Petrov
PY  - 2026
DA  - 2026/10/30
JO  - Liver international : official journal of the International Association for the Study of the Liver
DO  - 10.1111/liv.70934
UR  - https://europepmc.org/article/MED/42897902
AB  - Both liver fat content (LFC) and intrapancreatic fat deposition (IPFD) are frequently increased in Type 2 diabetes mellitus (T2DM). We meta-analysed dual-organ MRI studies comparing LFC between individuals with T2DM and non-diabetic controls and explored whether study-level differences in LFC varied according to IPFD burden. Seventeen studies (2142 participants) were included. Individuals with T2DM had significantly higher LFC than non-diabetic controls (standardised mean difference [SMD] 0.89, 95% CI 0.60-1.18). In exploratory subgroup analyses, liver fat excess was larger in studies with mean IPFD ≥ 10% than in those with IPFD < 10% (SMD 1.20 vs. 0.62; p = 0.04), though this finding was not consistently retained in leave-one-out analyses. Alternative IPFD cutoffs yielded directionally similar but non-significant subgroup differences. Study-level differences in IPFD were associated with differences in LFC (β = 0.383, p = 0.006) in univariable meta-regression, but not after BMI adjustment. These findings suggest that higher IPFD is associated with greater liver fat excess in T2DM at the study level. Individual-level analyses are now warranted to clarify this relationship.
SN  - 1478-3223
SN  - 1478-3231
ER  -