Case Report: Long-term survival in FIGO stage IVB small cell carcinoma of the ovary, pulmonary type following complete cytoreduction and platinum re-challenge
- 1Department of Obstetrics and Gynecology, School of Medicine, Daegu Catholic University
- 2Department of Pathology, School of Medicine, Daegu Catholic University
Abstract
Background: Small cell carcinoma of the ovary, pulmonary type (SCCOPT), is a rare and highly aggressive malignancy with poor prognosis. Long-term survival in advanced-stage disease has rarely been reported.
Case presentation: A 55-year-old postmenopausal woman presented with FIGO stage IVB SCCOPT accompanied by extensive peritoneal carcinomatosis and a solitary liver metastasis. No pulmonary lesion suggestive of primary lung malignancy was identified on CT, PET/CT, or chest radiography. She underwent aggressive primary cytoreductive surgery achieving complete macroscopic resection (R0), followed by four cycles of cisplatin and etoposide (EP). Sixteen months after diagnosis, isolated intracranial recurrence with multiple brain metastases were successfully treated with radiotherapy. Twenty-one months after diagnosis, systemic recurrence involving multiple liver metastases and a spinal metastasis was treated with six cycles of EP re-challenge, resulting in a marked radiologic response and subsequent durable disease control. The patient remained alive without clinical evidence of disease progression at the latest follow-up, 104 months after diagnosis.
Conclusions: This case suggests that prolonged survival may be achievable in selected patients with advanced SCCOPT through aggressive multimodal treatment. Complete cytoreductive surgery, platinum-based chemotherapy, including EP re-challenge following a prolonged platinum-free interval and previous response to platinum-based chemotherapy, and timely local treatment of metastatic lesions may contribute to durable disease control.
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BibTeX
@article{chae2026case,
title = {{Case Report: Long-term survival in FIGO stage IVB small cell carcinoma of the ovary, pulmonary type following complete cytoreduction and platinum re-challenge}},
author = {Hyun Joo Chae and Youn Seok Choi and Jong Im Lee and Yoon Young Jeong},
journal = {Frontiers in Oncology},
year = {2026},
month = oct,
doi = {10.3389/fonc.2026.1964342},
url = {https://www.frontiersin.org/articles/10.3389/fonc.2026.1964342/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Case Report: Long-term survival in FIGO stage IVB small cell carcinoma of the ovary, pulmonary type following complete cytoreduction and platinum re-challenge
AU - Hyun Joo Chae
AU - Youn Seok Choi
AU - Jong Im Lee
AU - Yoon Young Jeong
PY - 2026
DA - 2026/10/19
JO - Frontiers in Oncology
DO - 10.3389/fonc.2026.1964342
UR - https://www.frontiersin.org/articles/10.3389/fonc.2026.1964342/full
AB - Background: Small cell carcinoma of the ovary, pulmonary type (SCCOPT), is a rare and highly aggressive malignancy with poor prognosis. Long-term survival in advanced-stage disease has rarely been reported. Case presentation: A 55-year-old postmenopausal woman presented with FIGO stage IVB SCCOPT accompanied by extensive peritoneal carcinomatosis and a solitary liver metastasis. No pulmonary lesion suggestive of primary lung malignancy was identified on CT, PET/CT, or chest radiography. She underwent aggressive primary cytoreductive surgery achieving complete macroscopic resection (R0), followed by four cycles of cisplatin and etoposide (EP). Sixteen months after diagnosis, isolated intracranial recurrence with multiple brain metastases were successfully treated with radiotherapy. Twenty-one months after diagnosis, systemic recurrence involving multiple liver metastases and a spinal metastasis was treated with six cycles of EP re-challenge, resulting in a marked radiologic response and subsequent durable disease control. The patient remained alive without clinical evidence of disease progression at the latest follow-up, 104 months after diagnosis. Conclusions: This case suggests that prolonged survival may be achievable in selected patients with advanced SCCOPT through aggressive multimodal treatment. Complete cytoreductive surgery, platinum-based chemotherapy, including EP re-challenge following a prolonged platinum-free interval and previous response to platinum-based chemotherapy, and timely local treatment of metastatic lesions may contribute to durable disease control.
SN - 2234-943X
ER -