Compliance with guidelines for antibiotic therapy in infective endocarditis in older adults: a national-based real life retrospective cohort study
4 affiliations
- 1Department of Oncology, General Hospital of Valenciennes
- 2Inserm U853, Université de Bordeaux
- 3Department of Infectious Diseases, Centre Hospitalier Metropole Savoie
- 4EpiCliV Research Unit, Faculty of Medicine, University of the French West Indies
Abstract
Management of Infective Endocarditis (IE) is complex. This study aimed to describe compliance with the ESC 2015 guidelines of first-line antibiotic therapy in real life in older people. In this observational, longitudinal, retrospective, national-based, real-life cohort involving 34 French hospitals, we included patients aged 75 years or older, admitted with a diagnosis of possible or definite IE. In total, 929 patients were included (mean age of 83 ± 5 years; Mean Charlson comorbidity score of 3 ± 2) and 294 patients had at least one prosthetic valve. Left-sided IE was most frequent (76.2%), of which 42.8% involved the aortic valve. The most identified pathogens were Staphylococcus spp (42.2%) and Streptococcus spp (38.2%). In total, 43.9% patients had a first-line antibiotic regimen non-compliant with guidelines. By multivariable analysis, the factors independently associated with non-compliance to recommendations for first-line antibiotic treatment were BMI ≥ 25 kg/m2, IE located on a native valve (aortic or mitral), and the presence of suspected healthcare-associated IE. Compliance did not differ fundamentally according to the publication year of guidelines (ESC 2015 versus ESC 2023). In conclusion, despite the robustness of the procedures for producing practice guidelines, compliance is low, probably because there are no specific guidelines for older people.
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BibTeX
@article{godaert2026compliance,
title = {{Compliance with guidelines for antibiotic therapy in infective endocarditis in older adults: a national-based real life retrospective cohort study}},
author = {Lidvine Godaert and Claire Roubaud -Baudron and Emmanuel Forestier and Moustapha Dramé and the ENDOLA Study group},
journal = {Scientific Reports},
year = {2026},
month = aug,
doi = {10.1038/s41598-026-63207-6},
url = {https://doi.org/10.1038/s41598-026-63207-6},
note = {CC BY},
}
RIS
TY - JOUR
TI - Compliance with guidelines for antibiotic therapy in infective endocarditis in older adults: a national-based real life retrospective cohort study
AU - Lidvine Godaert
AU - Claire Roubaud -Baudron
AU - Emmanuel Forestier
AU - Moustapha Dramé
AU - the ENDOLA Study group
PY - 2026
DA - 2026/08/01
JO - Scientific Reports
DO - 10.1038/s41598-026-63207-6
UR - https://doi.org/10.1038/s41598-026-63207-6
AB - Management of Infective Endocarditis (IE) is complex. This study aimed to describe compliance with the ESC 2015 guidelines of first-line antibiotic therapy in real life in older people. In this observational, longitudinal, retrospective, national-based, real-life cohort involving 34 French hospitals, we included patients aged 75 years or older, admitted with a diagnosis of possible or definite IE. In total, 929 patients were included (mean age of 83 ± 5 years; Mean Charlson comorbidity score of 3 ± 2) and 294 patients had at least one prosthetic valve. Left-sided IE was most frequent (76.2%), of which 42.8% involved the aortic valve. The most identified pathogens were Staphylococcus spp (42.2%) and Streptococcus spp (38.2%). In total, 43.9% patients had a first-line antibiotic regimen non-compliant with guidelines. By multivariable analysis, the factors independently associated with non-compliance to recommendations for first-line antibiotic treatment were BMI ≥ 25 kg/m2, IE located on a native valve (aortic or mitral), and the presence of suspected healthcare-associated IE. Compliance did not differ fundamentally according to the publication year of guidelines (ESC 2015 versus ESC 2023). In conclusion, despite the robustness of the procedures for producing practice guidelines, compliance is low, probably because there are no specific guidelines for older people.
SN - 2045-2322
ER -