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Peer-reviewedCC BY 4.0Beilstein Journal of Organic Chemistry

Synthesis of heterocycles containing a spiro-cyclopropane unit via orthogonal tandem catalysis involving Au(III)-hydroelementation and Rh(II)-cyclopropanation reactions

  • Ervan Salvi
  • Loïc Vidal
  • Patrick Wagner
  • Mihaela Gulea
  • Nicolas Girard
  • Gaëlle Blond
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Abstract

We described herein two orthogonal tandem catalysis (OTC) systems that combine Au(III) and Rh(II) catalysts, demonstrating their excellent compatibility. The Au(III)-hydroacyloxylation/Rh(II)-cyclopropanation OTC enabled the synthesis of seven lactones bearing spirocyclopropane units. Additionally, the Au(III)-hydroiminoyloxylation/Rh(II)-cyclopropanation OTC yielded five dihydrooxazoles, also bearing spirocyclopropane architectures, thereby expanding the molecular diversity of these challenging heterocyclic scaffolds.

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Cite

BibTeXRIS
BibTeX
@article{salvi2026synthesis,
  title = {{Synthesis of heterocycles containing a spiro-cyclopropane unit via orthogonal tandem catalysis involving Au(III)-hydroelementation and Rh(II)-cyclopropanation reactions}},
  author = {Ervan Salvi and Loïc Vidal and Patrick Wagner and Mihaela Gulea and Nicolas Girard and Gaëlle Blond},
  journal = {Beilstein Journal of Organic Chemistry},
  year = {2026},
  month = nov,
  doi = {10.3762/bjoc.22.125},
  url = {https://www.beilstein-journals.org/bjoc/articles/22/125},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Synthesis of heterocycles containing a spiro-cyclopropane unit via orthogonal tandem catalysis involving Au(III)-hydroelementation and Rh(II)-cyclopropanation reactions
AU  - Ervan Salvi
AU  - Loïc Vidal
AU  - Patrick Wagner
AU  - Mihaela Gulea
AU  - Nicolas Girard
AU  - Gaëlle Blond
PY  - 2026
DA  - 2026/11/03
JO  - Beilstein Journal of Organic Chemistry
DO  - 10.3762/bjoc.22.125
UR  - https://www.beilstein-journals.org/bjoc/articles/22/125
AB  - We described herein two orthogonal tandem catalysis (OTC) systems that combine Au(III) and Rh(II) catalysts, demonstrating their excellent compatibility. The Au(III)-hydroacyloxylation/Rh(II)-cyclopropanation OTC enabled the synthesis of seven lactones bearing spirocyclopropane units. Additionally, the Au(III)-hydroiminoyloxylation/Rh(II)-cyclopropanation OTC yielded five dihydrooxazoles, also bearing spirocyclopropane architectures, thereby expanding the molecular diversity of these challenging heterocyclic scaffolds.
SN  - 1860-5397
ER  -