Pulse wave velocity as a non-invasive discriminative marker of bone health in postmenopausal women.
8 affiliations
- 1University "St Kliment Ohridski" Bitola, Clinical Hospital - Bitola, Department of Gynecology and Obstetrics, Bitola, North Macedonia.
- 2Medico - Legal Department, MedAssess, Sydney, New South Wales, Australia.
- 3University "St Kliment Ohridski" Bitola, Clinical Hospital - Bitola, Department of Internal medicine, Bitola, North Macedonia.
- 4Clinical Hospital - Bitola, Department of Nuclear medicine, Bitola, North Macedonia.
- 5Clinical Hospital - Bitola, Department of Surgery, Bitola, North Macedonia.
- 6Clinical Hospital - Bitola, North Macedonia, Department of Cardiology, Bitola, North Macedonia.
- 7University "St. Kliment Ohridski" - Bitola, Faculty of Economics -Prilep, Department of statistics, Prilep, North Macedonia.
- 8University "St. Kliment Ohridski" - Bitola, Faculty of Economics -Prilep, Head of the Second Cycle of Studies, Prilep, North Macedonia.
Abstract
Background
Increased arterial stiffness has been linked to osteoporosis. This study evaluates Pulse Wave Velocity (PWV) as a discriminator of osteopenia and osteoporosis at the lumbar spine and femoral neck in postmenopausal women.Methods
In this cross-sectional study, arterial stiffness and bone mineral density (BMD) at the spine and femoral neck were assessed using carotid-to-femoral Pulse PWV and dual-energy x-ray absorptiometry (DXA). Eighteen premenopausal women (mean age 41.30±4.30 years) and forty-eight postmenopausal women (mean age 59.40±9.10 years) participated in the study. Osteoporosis (T-score ≤-2.5) and osteopenia (-2.5< T-score ≤-1) were defined by T-score criteria.Results
Pearson's correlation results showed: PWV and femoral neck BMD (r = -0.439, P = 0.002), PWV and spine BMD (r =-0.358, P = 0.012), and PWV and menopausal duration (r = 0.381, P = 0.008). PWV demonstrated significant discriminative ability for femoral neck osteopenia [b = 0.6472, Wald = 5.717, Odds ratio (OR) = 1.910, P = 0.017, Area Under Curve (AUC) = 0.704], femoral neck osteoporosis (b = 0.7206, Wald = 5.838, OR = 2.056, P = 0.016, AUC = 0.758), spine osteopenia (b = 0.8489, Wald = 5.639, OR = 2.337, P = 0.018, AUC = 0.677), and spine osteoporosis (b = 1.0829, Wald = 8.269, OR = 2.953, P = 0.004, AUC = 0.804).Conclusion
PWV was inversely correlated with femoral neck and spine BMD, and positively correlated with menopausal duration. It serves as a significant discriminator of bone health, indicating increased odds of osteopenia and osteoporosis.
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BibTeX
@article{avramovska2026pulse,
title = {{Pulse wave velocity as a non-invasive discriminative marker of bone health in postmenopausal women.}},
author = {Maja Avramovska and Zorica Nikleski and Petar Avramovski and Liljana Todorovska and Stefan Talev and Svetlana Stefanovska and Kosta Sotiroski and Dejan Zdraveski},
journal = {Caspian journal of internal medicine},
year = {2026},
month = sep,
doi = {10.22088/cjim.17.3.622},
url = {https://europepmc.org/article/MED/42924368},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Pulse wave velocity as a non-invasive discriminative marker of bone health in postmenopausal women.
AU - Maja Avramovska
AU - Zorica Nikleski
AU - Petar Avramovski
AU - Liljana Todorovska
AU - Stefan Talev
AU - Svetlana Stefanovska
AU - Kosta Sotiroski
AU - Dejan Zdraveski
PY - 2026
DA - 2026/09/01
JO - Caspian journal of internal medicine
DO - 10.22088/cjim.17.3.622
UR - https://europepmc.org/article/MED/42924368
AB - Background Increased arterial stiffness has been linked to osteoporosis. This study evaluates Pulse Wave Velocity (PWV) as a discriminator of osteopenia and osteoporosis at the lumbar spine and femoral neck in postmenopausal women.Methods In this cross-sectional study, arterial stiffness and bone mineral density (BMD) at the spine and femoral neck were assessed using carotid-to-femoral Pulse PWV and dual-energy x-ray absorptiometry (DXA). Eighteen premenopausal women (mean age 41.30±4.30 years) and forty-eight postmenopausal women (mean age 59.40±9.10 years) participated in the study. Osteoporosis (T-score ≤-2.5) and osteopenia (-2.5< T-score ≤-1) were defined by T-score criteria.Results Pearson's correlation results showed: PWV and femoral neck BMD (r = -0.439, P = 0.002), PWV and spine BMD (r =-0.358, P = 0.012), and PWV and menopausal duration (r = 0.381, P = 0.008). PWV demonstrated significant discriminative ability for femoral neck osteopenia [b = 0.6472, Wald = 5.717, Odds ratio (OR) = 1.910, P = 0.017, Area Under Curve (AUC) = 0.704], femoral neck osteoporosis (b = 0.7206, Wald = 5.838, OR = 2.056, P = 0.016, AUC = 0.758), spine osteopenia (b = 0.8489, Wald = 5.639, OR = 2.337, P = 0.018, AUC = 0.677), and spine osteoporosis (b = 1.0829, Wald = 8.269, OR = 2.953, P = 0.004, AUC = 0.804).Conclusion PWV was inversely correlated with femoral neck and spine BMD, and positively correlated with menopausal duration. It serves as a significant discriminator of bone health, indicating increased odds of osteopenia and osteoporosis.
SN - 2008-6164
SN - 2008-6172
ER -