A Pilot Study of Linezolid for Early Syphilis Treatment

Abstract

In a study of oral linezolid among 18 patients with early syphilis, 15 showed adequate serological response by 6 months. Among 6 patients treated with benzathine penicillin G, 5 showed adequate serological response. There were no serious adverse events. Linezolid shows promise for the treatment of early syphilis.

Early intermittent low-dose sclerostin antibody treatment promotes surface bone formation and reduces bone loss, but also decreases osteocyte apoptosis and mechanotransduction in ovariectomized rats: A pilot study
Syeda Masooma Naqvi, Wahaaj Ali, Hollie Allison +5
Bone Reports29 Oct 2026Peer-reviewedCC BY 4.0Full text1 citedSurgery & anaesthesiaHAL
Epidemiology of Syphilis, Diagnosis, Differential Diagnosis and Treatment: Up-to-Date Knowledge
Journal of clinical medicine24 Sep 2026Peer-reviewedCC BYFull textGeneral medicineEurope PMC
Early Changes in Spleen Stiffness After Endoscopic Treatment Are Associated with Esophageal Variceal Recurrence: A Pilot Study
Akira Uchiyama, Shunhei Yamashina, Satoshi Sakuma +8
Journal of Clinical Medicine12 Oct 2026Peer-reviewedCC BY 4.0General medicineCrossref
Necrotizing Enterocolitis Secondary to Congenital Syphilis in an 18-Day-Old Neonate: Successful Treatment With Intravenous Penicillin.
Chariya Chap, Vissotsak Bin, Sakviseth Bin
Case reports in infectious diseases21 Oct 2026Peer-reviewedCC BYFull textGeneral medicineEurope PMC
Comparative effectiveness of three benzathine penicillin G-based regimens in people with HIV who presented with early syphilis
Kai-Hsiang Chen, Hsin-Yun Sun, Kuan-Yin Lin +9
International Journal of Infectious Diseases30 Oct 2026Peer-reviewedCC BYFull textPhysiologyDOAJ

Cite

BibTeX RIS

BibTeX

@article{nguyen2026pilot,
  title = {{A Pilot Study of Linezolid for Early Syphilis Treatment}},
  author = {Ryan M Nguyen and Chrysovalantis Stafylis and Kelika A Konda and E Michael Reyes-Diaz and Kori Keith and Keith Stokes and Catherine Creticos and Candice J McNeil and Philip A Chan and James B Brock and Byron Buck and Ebony Warren and Rica M Abbott and Jennifer L Nall and Peter Salhaney and Takila Keys and Jeffrey D Klausner},
  journal = {Open forum infectious diseases},
  year = {2026},
  month = oct,
  doi = {10.1093/ofid/ofag690},
  url = {https://europepmc.org/article/PMC/PMC13728569},
  note = {CC BY},
}

RIS

TY  - JOUR
TI  - A Pilot Study of Linezolid for Early Syphilis Treatment
AU  - Ryan M Nguyen
AU  - Chrysovalantis Stafylis
AU  - Kelika A Konda
AU  - E Michael Reyes-Diaz
AU  - Kori Keith
AU  - Keith Stokes
AU  - Catherine Creticos
AU  - Candice J McNeil
AU  - Philip A Chan
AU  - James B Brock
AU  - Byron Buck
AU  - Ebony Warren
AU  - Rica M Abbott
AU  - Jennifer L Nall
AU  - Peter Salhaney
AU  - Takila Keys
AU  - Jeffrey D Klausner
PY  - 2026
DA  - 2026/10/24
JO  - Open forum infectious diseases
DO  - 10.1093/ofid/ofag690
UR  - https://europepmc.org/article/PMC/PMC13728569
AB  - In a study of oral linezolid among 18 patients with early syphilis, 15 showed adequate serological response by 6 months. Among 6 patients treated with benzathine penicillin G, 5 showed adequate serological response. There were no serious adverse events. Linezolid shows promise for the treatment of early syphilis.
SN  - 2328-8957
ER  -

Abstract

Related

Cite