Rapidly Progressive Buschke-Löwenstein Tumor Managed With Wide Local Excision and Healing by Secondary Intention: A Case Report and Literature Review.
- 1Department of Colon and Rectal Surgery Jackson South Medical Center Miami Florida USA.
- 2Department of Surgery School of Medicine St. George's University True Blue Grenada sgu.edu.
- 3School of Medicine and Health Sciences University of Rosario Bogotá Colombia urosario.edu.co.
Abstract
Buschke-Löwenstein tumor (BLT) is a rare, locally aggressive anogenital tumor associated predominantly with low-risk human papillomavirus (HPV) types 6 and 11. BLT is classically described as a slow-growing lesion predominantly affecting middle-aged men who are immunocompromised; cases of rapid progression are rarely reported. We present the case of a 23-year-old male with a progressively enlarging perianal mass over 1 year that was accompanied by rectal pain and intermittent bleeding. He reported prior unprotected heterosexual intercourse, though serologic testing for HIV, syphilis, and hepatitis B/C was negative. CT imaging revealed a fungating lesion entirely distal to the dentate line without evidence of internal extension. Subsequently, the patient underwent wide local excision with electrocautery fulguration, and the wound was managed with healing by secondary intention. Histopathology revealed clear margins around a low-grade squamous intraepithelial lesion (LSIL) without high-grade dysplasia or carcinoma; in situ hybridization (ISH) confirmed HPV types 6 and 11, without detection of high-risk HPV. A review of the literature on BLT epidemiology, histopathology, differential diagnosis, and management is presented. This case illustrates that BLT can progress rapidly in young, immunocompetent individuals and highlights that healing by secondary intention following wide local excision is a viable option in appropriately selected cases.
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BibTeX
@article{chin2026rapidly,
title = {{Rapidly Progressive Buschke-Löwenstein Tumor Managed With Wide Local Excision and Healing by Secondary Intention: A Case Report and Literature Review.}},
author = {Sabrina E Chin and Natalia Rojas Castro and Henry J Lujan},
journal = {Case reports in surgery},
year = {2026},
month = oct,
doi = {10.1155/cris/4587993},
url = {https://europepmc.org/article/MED/42904058},
note = {CC BY},
}
RIS
TY - JOUR
TI - Rapidly Progressive Buschke-Löwenstein Tumor Managed With Wide Local Excision and Healing by Secondary Intention: A Case Report and Literature Review.
AU - Sabrina E Chin
AU - Natalia Rojas Castro
AU - Henry J Lujan
PY - 2026
DA - 2026/10/20
JO - Case reports in surgery
DO - 10.1155/cris/4587993
UR - https://europepmc.org/article/MED/42904058
AB - Buschke-Löwenstein tumor (BLT) is a rare, locally aggressive anogenital tumor associated predominantly with low-risk human papillomavirus (HPV) types 6 and 11. BLT is classically described as a slow-growing lesion predominantly affecting middle-aged men who are immunocompromised; cases of rapid progression are rarely reported. We present the case of a 23-year-old male with a progressively enlarging perianal mass over 1 year that was accompanied by rectal pain and intermittent bleeding. He reported prior unprotected heterosexual intercourse, though serologic testing for HIV, syphilis, and hepatitis B/C was negative. CT imaging revealed a fungating lesion entirely distal to the dentate line without evidence of internal extension. Subsequently, the patient underwent wide local excision with electrocautery fulguration, and the wound was managed with healing by secondary intention. Histopathology revealed clear margins around a low-grade squamous intraepithelial lesion (LSIL) without high-grade dysplasia or carcinoma; in situ hybridization (ISH) confirmed HPV types 6 and 11, without detection of high-risk HPV. A review of the literature on BLT epidemiology, histopathology, differential diagnosis, and management is presented. This case illustrates that BLT can progress rapidly in young, immunocompetent individuals and highlights that healing by secondary intention following wide local excision is a viable option in appropriately selected cases.
SN - 2090-6900
SN - 2090-6919
ER -