Exploring glycocalyx components powering the contact between Entamoeba histolytica and bacteria during non-opsonic phagocytosis
- 1Institut Pasteur, Université Paris Cité, Biological Image Analysis Unit, Centre National de la Recherche Scientifique UMR3691, Paris, France
Abstract
Phagocytosis is a cornerstone of the immune defence, allowing cells to eliminate pathogens through both opsonic and non-opsonic pathways. In protozoa such as Entamoeba histolytica, non-opsonic phagocytosis is not only central to survival but also to its ability to cause disease, with its life cycle closely intertwined with the intestinal microbiota, which supplies bacteria and their metabolic byproducts to support trophozoite growth. Yet, despite its significance, the molecular basis of how E. histolytica recognises and engulfs bacteria remains largely unresolved. This review examines the cell-surface molecules that may mediate bacteria–amoeba interactions and highlights new strategies to uncover their roles, offering fresh insight into the dynamics of non-opsonic phagocytosis.
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BibTeX
@article{labruyere2026exploring,
title = {{Exploring glycocalyx components powering the contact between Entamoeba histolytica and bacteria during non-opsonic phagocytosis}},
author = {Elisabeth Labruyère and Thomas Treport and Jean-Christophe Olivo-Marin and Nancy Guillen},
journal = {PLOS Pathogens},
year = {2026},
month = sep,
doi = {10.1371/journal.ppat.1014560},
url = {https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1014560},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Exploring glycocalyx components powering the contact between Entamoeba histolytica and bacteria during non-opsonic phagocytosis
AU - Elisabeth Labruyère
AU - Thomas Treport
AU - Jean-Christophe Olivo-Marin
AU - Nancy Guillen
PY - 2026
DA - 2026/09/21
JO - PLOS Pathogens
DO - 10.1371/journal.ppat.1014560
UR - https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1014560
AB - Phagocytosis is a cornerstone of the immune defence, allowing cells to eliminate pathogens through both opsonic and non-opsonic pathways. In protozoa such as Entamoeba histolytica, non-opsonic phagocytosis is not only central to survival but also to its ability to cause disease, with its life cycle closely intertwined with the intestinal microbiota, which supplies bacteria and their metabolic byproducts to support trophozoite growth. Yet, despite its significance, the molecular basis of how E. histolytica recognises and engulfs bacteria remains largely unresolved. This review examines the cell-surface molecules that may mediate bacteria–amoeba interactions and highlights new strategies to uncover their roles, offering fresh insight into the dynamics of non-opsonic phagocytosis.
SN - 1553-7374
SN - 1553-7366
ER -