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Peer-reviewedCC BY-NC 4.0BMJ Case Reports

Malignant histiocytic neoplasm with dendritic differentiation via transdifferentiation of B-cell lymphoma

  • Chao Wu1
  • Wei Cui2
  • Aung M Tun3
  1. 1Department of Internal Medicine, The University of Kansas Medical Center, Kansas City, Kansas, USA
  2. 2Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, Kansas, USA
  3. 3Division of Hematologic Malignancies and Cellular Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas, USA
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Abstract

Follicular lymphoma commonly transforms into diffuse large B-cell lymphoma; however, transdifferentiation into histiocytic/dendritic neoplasms is exceptionally rare. We describe an older male with follicular lymphoma that transformed into high-grade B-cell lymphoma with MYC, BCL2 and BCL6 rearrangements, followed by development of a malignant histiocytic neoplasm with dendritic differentiation involving the liver. Shared molecular findings supported transdifferentiation from the original lymphoma clone. While the malignant histiocytic neoplasm showed a complete response to imatinib, the clinical course was complicated by relapsed high-grade B-cell lymphoma and the patient eventually succumbed to infectious complications.

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Cite

BibTeXRIS
BibTeX
@article{wu2026malignant,
  title = {{Malignant histiocytic neoplasm with dendritic differentiation via transdifferentiation of B-cell lymphoma}},
  author = {Chao Wu and Wei Cui and Aung M Tun},
  journal = {BMJ Case Reports},
  year = {2026},
  month = oct,
  doi = {10.1136/bcr-2026-273164},
  url = {https://doi.org/10.1136/bcr-2026-273164},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Malignant histiocytic neoplasm with dendritic differentiation via transdifferentiation of B-cell lymphoma
AU  - Chao Wu
AU  - Wei Cui
AU  - Aung M Tun
PY  - 2026
DA  - 2026/10/30
JO  - BMJ Case Reports
DO  - 10.1136/bcr-2026-273164
UR  - https://doi.org/10.1136/bcr-2026-273164
AB  - Follicular lymphoma commonly transforms into diffuse large B-cell lymphoma; however, transdifferentiation into histiocytic/dendritic neoplasms is exceptionally rare. We describe an older male with follicular lymphoma that transformed into high-grade B-cell lymphoma with MYC, BCL2 and BCL6 rearrangements, followed by development of a malignant histiocytic neoplasm with dendritic differentiation involving the liver. Shared molecular findings supported transdifferentiation from the original lymphoma clone. While the malignant histiocytic neoplasm showed a complete response to imatinib, the clinical course was complicated by relapsed high-grade B-cell lymphoma and the patient eventually succumbed to infectious complications.
SN  - 1757-790X
ER  -