Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 57 min ago
Peer-reviewedCC BY-NC-NDJournal of health, population, and nutrition

The clinical significance of the modified Naples prognostic score for prostate cancer: a population-based study.

  • Hong Zeng1
  • Fan Yang1
  • Qian Wang2
  • Tianyi Zhang1
  • Junhao Chen1
  • Shijie Jin1
  • Tianrui Feng1
  • Zhen Liang1
  • Yuliang Chen1
  • Zhiwei Xie1
  • Chenhui Tang1
  • Zhien Zhou1
2 more authors
  • Yi Zhou3
  • Weigang Yan4
4 affiliations
  1. 1Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
  2. 2Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
  3. 3Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China. [email protected].
  4. 4Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China. [email protected].
Read full textPDFDOICite

Abstract

Purpose

The Naples Prognostic Score (NPS) is a widely recognized scoring system used to assess inflammation and nutrition status, yet its role in prostate cancer (PCa) remains unclear. This study aims to investigate the association between the modified NPS (MNPS) and PCa prevalence and mortality outcomes among participants with self-reported PCa.Methods

Data from the National Health and Nutrition Examination Survey 1999-2018 were collected. The NPS was calculated using MaxStat analysis, while M1NPS and M2NPS were constructed with X-Tile analysis. Weighted logistic regression was used to estimate the odds ratio (OR) for PCa prevalence. Kaplan-Meier survival analysis, log-rank tests, and Cox proportional hazard ratios (HR) were employed to analyze the mortality risk.Results

Among 22,027 individuals, 717 had PCa. After considering the interactions among different factors and adjusting for confounding variables, the prevalence of PCa was notably higher in participants with the highest MNPS groups (group 3) compared with those with the lowest groups (group 1) (OR (95% CI) = 2.96 (1.57-5.57) for M1NPS; 15.50 (1.78-134.71) for M2NPS). With a median follow-up of 9.92 years, 326 (45.47%) of all-cause deaths occurred among participants with self-reported PCa. Significant differences in all-cause mortality were observed between the MNPS groups (log-rank P < 0.001 for M1NPS and M2NPS). Compared to participants with self-reported PCa in group 1, the adjusted HRs for all-cause mortality in group 3 were 1.12 (95% CI: 0.49-2.57) for M1NPS and 2.02 (95% CI: 1.19-3.44) for M2NPS. Furthermore, a significant association was found between M2NPS and cardiovascular mortality (HR (95% CI) = 4.77 (1.95-11.65).Conclusion

The modified and optimized NPS, which integrates inflammation and nutritional status, is associated with PCa prevalence and with all-cause and cardiovascular mortality among individuals with self-reported PCa.

Related

  1. Prognostic and Clinical Significance of Circulating Cystatin C Levels in Cancer Patients: A Meta-Analysis
    Sehreen Tory, Md. Mojahidur Hasan, Yusuf Kemal Arslan +2
    Asian Pacific Journal of Cancer Prevention : APJCPPeer-reviewedCC BY-NC 4.0Full textOncologyPMC
  2. The clinical and biological significance of TBRG4 expression in prostate cancer
    Wenxuan Li, Xi Xiao, Ting Wang +10
    Frontiers in OncologyPeer-reviewedCC BY 4.0OncologyCrossref
  3. Clinical and prognostic significance of the C-reactive protein-albumin-lymphocyte (CALLY) index in breast cancer: a systematic review and meta-analysis
    K. Jalalian Rad, S. Kadri, A. Yakiti +4
    medRxivPreprintCC BY-NC-NDFull textOncologymedRxiv
  4. Prognostic Significance and Clinical Robustness of the HALP Score in Super-Elderly Patients Undergoing Curative Gastrectomy for Gastric Cancer: A Multicenter Retrospective Cohort Study.
    Hiroyuki Inoue, Takeshi Kubota, Toshiyuki Kosuga +14
    Annals of gastroenterological surgeryPeer-reviewedCC BY-NC-NDFull textOncologyEurope PMC
  5. A population-based resource for the prioritization of rare variants of unknown significance in clinical genomics
    S. Tremblay, C. Moreau, G.-P. Morin +2
    medRxivPreprintCC BY-NCFull textHuman geneticsmedRxiv

Cite

BibTeXRIS
BibTeX
@article{zeng2026clinical,
  title = {{The clinical significance of the modified Naples prognostic score for prostate cancer: a population-based study.}},
  author = {Hong Zeng and Fan Yang and Qian Wang and Tianyi Zhang and Junhao Chen and Shijie Jin and Tianrui Feng and Zhen Liang and Yuliang Chen and Zhiwei Xie and Chenhui Tang and Zhien Zhou and Yi Zhou and Weigang Yan},
  journal = {Journal of health, population, and nutrition},
  year = {2026},
  month = jul,
  doi = {10.1186/s41043-026-01402-x},
  url = {https://europepmc.org/article/MED/42902334},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - The clinical significance of the modified Naples prognostic score for prostate cancer: a population-based study.
AU  - Hong Zeng
AU  - Fan Yang
AU  - Qian Wang
AU  - Tianyi Zhang
AU  - Junhao Chen
AU  - Shijie Jin
AU  - Tianrui Feng
AU  - Zhen Liang
AU  - Yuliang Chen
AU  - Zhiwei Xie
AU  - Chenhui Tang
AU  - Zhien Zhou
AU  - Yi Zhou
AU  - Weigang Yan
PY  - 2026
DA  - 2026/07/01
JO  - Journal of health, population, and nutrition
DO  - 10.1186/s41043-026-01402-x
UR  - https://europepmc.org/article/MED/42902334
AB  - Purpose  The Naples Prognostic Score (NPS) is a widely recognized scoring system used to assess inflammation and nutrition status, yet its role in prostate cancer (PCa) remains unclear. This study aims to investigate the association between the modified NPS (MNPS) and PCa prevalence and mortality outcomes among participants with self-reported PCa.Methods  Data from the National Health and Nutrition Examination Survey 1999-2018 were collected. The NPS was calculated using MaxStat analysis, while M1NPS and M2NPS were constructed with X-Tile analysis. Weighted logistic regression was used to estimate the odds ratio (OR) for PCa prevalence. Kaplan-Meier survival analysis, log-rank tests, and Cox proportional hazard ratios (HR) were employed to analyze the mortality risk.Results  Among 22,027 individuals, 717 had PCa. After considering the interactions among different factors and adjusting for confounding variables, the prevalence of PCa was notably higher in participants with the highest MNPS groups (group 3) compared with those with the lowest groups (group 1) (OR (95% CI) = 2.96 (1.57-5.57) for M1NPS; 15.50 (1.78-134.71) for M2NPS). With a median follow-up of 9.92 years, 326 (45.47%) of all-cause deaths occurred among participants with self-reported PCa. Significant differences in all-cause mortality were observed between the MNPS groups (log-rank P < 0.001 for M1NPS and M2NPS). Compared to participants with self-reported PCa in group 1, the adjusted HRs for all-cause mortality in group 3 were 1.12 (95% CI: 0.49-2.57) for M1NPS and 2.02 (95% CI: 1.19-3.44) for M2NPS. Furthermore, a significant association was found between M2NPS and cardiovascular mortality (HR (95% CI) = 4.77 (1.95-11.65).Conclusion  The modified and optimized NPS, which integrates inflammation and nutritional status, is associated with PCa prevalence and with all-cause and cardiovascular mortality among individuals with self-reported PCa.
SN  - 1606-0997
SN  - 2072-1315
ER  -