A Multimodal Neuroimaging Study of Hyperlipidemia-Induced Abnormal Spontaneous Brain Activity and Cognitive Decline.
4 affiliations
- 1Department of Orthopedics and Traumatology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
- 2Department of Rehabilitation Medicine, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
- 3School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
- 4Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, People's Republic of China.
Abstract
Objective
To investigate multidomain cognitive performance in older adults with hyperlipidemia and its associations with alterations in spontaneous brain activity and functional connectivity (FC).Methods
A total of 104 participants were recruited, comprising 50 hyperlipidemia patients and 54 healthy controls. Comprehensive psychological assessments were conducted, and resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from both groups. Amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo), and FC were calculated.Results
Compared with healthy controls, hyperlipidemia patients showed significantly lower SDMT scores (p < 0.001), whereas no significant between-group differences were observed in the other neuropsychological measures. Imaging analyses revealed altered spontaneous brain activity and FC involving frontal, temporal, and cerebellar regions. In exploratory correlation analyses, lower SDMT scores and longer STT-B completion times were associated with higher zALFF values in the right inferior temporal gyrus (r = -0.197, p = 0.046); however, the SDMT association was modest and did not survive correction for multiple comparisons (r = 0.257, p = 0.009). Age also positively correlated with zALFF in this region (r = 0.195, p = 0.048).Conclusions
Hyperlipidemia was associated with lower SDMT performance, altered spontaneous activity, and functional connectivity in the frontal, temporal, and cerebellar regions. The exploratory associations involving the right inferior temporal gyrus suggest a potential relationship between altered regional brain activity and cognitive performance.
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BibTeX
@article{he2026multimodal,
title = {{A Multimodal Neuroimaging Study of Hyperlipidemia-Induced Abnormal Spontaneous Brain Activity and Cognitive Decline.}},
author = {Jian-Hui He and Jia-Jia Wu and Fan-Long Meng and Yun-Ting Xiang and Rong-Rong Huang and Mou-Xiong Zheng and Jie Ma and Jian-Guang Xu},
journal = {Brain and behavior},
year = {2026},
month = nov,
doi = {10.1002/brb3.71890},
url = {https://europepmc.org/article/MED/42975146},
note = {CC BY},
}
RIS
TY - JOUR
TI - A Multimodal Neuroimaging Study of Hyperlipidemia-Induced Abnormal Spontaneous Brain Activity and Cognitive Decline.
AU - Jian-Hui He
AU - Jia-Jia Wu
AU - Fan-Long Meng
AU - Yun-Ting Xiang
AU - Rong-Rong Huang
AU - Mou-Xiong Zheng
AU - Jie Ma
AU - Jian-Guang Xu
PY - 2026
DA - 2026/11/01
JO - Brain and behavior
DO - 10.1002/brb3.71890
UR - https://europepmc.org/article/MED/42975146
AB - Objective To investigate multidomain cognitive performance in older adults with hyperlipidemia and its associations with alterations in spontaneous brain activity and functional connectivity (FC).Methods A total of 104 participants were recruited, comprising 50 hyperlipidemia patients and 54 healthy controls. Comprehensive psychological assessments were conducted, and resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from both groups. Amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo), and FC were calculated.Results Compared with healthy controls, hyperlipidemia patients showed significantly lower SDMT scores (p < 0.001), whereas no significant between-group differences were observed in the other neuropsychological measures. Imaging analyses revealed altered spontaneous brain activity and FC involving frontal, temporal, and cerebellar regions. In exploratory correlation analyses, lower SDMT scores and longer STT-B completion times were associated with higher zALFF values in the right inferior temporal gyrus (r = -0.197, p = 0.046); however, the SDMT association was modest and did not survive correction for multiple comparisons (r = 0.257, p = 0.009). Age also positively correlated with zALFF in this region (r = 0.195, p = 0.048).Conclusions Hyperlipidemia was associated with lower SDMT performance, altered spontaneous activity, and functional connectivity in the frontal, temporal, and cerebellar regions. The exploratory associations involving the right inferior temporal gyrus suggest a potential relationship between altered regional brain activity and cognitive performance.
SN - 2162-3279
ER -