EFA6A regulates retinal function through the control of photoreceptor cell activity and structure
Abstract
The initial step in visual perception, i.e., the collection of light, is carried out by the outer segments of photoreceptor cells. These outer segments, specialized primary cilia, house the photopigments that absorb photons. Here, we report that EFA6A, an exchange factor for the small G protein Arf6, previously described as a regulator of early ciliogenesis by promoting distal appendage vesicle fusion, is essential for visual function. We demonstrate that EFA6A is present in various layers of the mouse retina, including the photoreceptors and the retinal pigment epithelium (RPE). Accordingly, depletion of EFA6A in the mouse retina leads to both morphological and functional defects in photoreceptors, resembling the phenotypes observed in retinal ciliopathies. We also show that EFA6A depletion in RPE cells severely impairs their phagocytic activity. Thus, our results point out a key role for EFA6A in the control of visual activity.
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BibTeX
@article{abelanet2026efa6a,
title = {{EFA6A regulates retinal function through the control of photoreceptor cell activity and structure}},
author = {Sophie Abélanet and Sophie Pagnotta and Frédéric Brau and Marie Péquignot and Valérie Scheuermann and Sandra Lacas-Gervais and Carole Rovere and Alain Corinus and Lætitia Della-Croce and Cécile Delettre and Frédéric Luton and Michel Franco},
journal = {iScience},
year = {2026},
month = sep,
doi = {10.1016/j.isci.2026.115179},
url = {https://hal.science/hal-05768652v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - EFA6A regulates retinal function through the control of photoreceptor cell activity and structure
AU - Sophie Abélanet
AU - Sophie Pagnotta
AU - Frédéric Brau
AU - Marie Péquignot
AU - Valérie Scheuermann
AU - Sandra Lacas-Gervais
AU - Carole Rovere
AU - Alain Corinus
AU - Lætitia Della-Croce
AU - Cécile Delettre
AU - Frédéric Luton
AU - Michel Franco
PY - 2026
DA - 2026/09/29
JO - iScience
DO - 10.1016/j.isci.2026.115179
UR - https://hal.science/hal-05768652v1
AB - The initial step in visual perception, i.e., the collection of light, is carried out by the outer segments of photoreceptor cells. These outer segments, specialized primary cilia, house the photopigments that absorb photons. Here, we report that EFA6A, an exchange factor for the small G protein Arf6, previously described as a regulator of early ciliogenesis by promoting distal appendage vesicle fusion, is essential for visual function. We demonstrate that EFA6A is present in various layers of the mouse retina, including the photoreceptors and the retinal pigment epithelium (RPE). Accordingly, depletion of EFA6A in the mouse retina leads to both morphological and functional defects in photoreceptors, resembling the phenotypes observed in retinal ciliopathies. We also show that EFA6A depletion in RPE cells severely impairs their phagocytic activity. Thus, our results point out a key role for EFA6A in the control of visual activity.
SN - 2589-0042
ER -