Association between the uric acid to high‑density lipoprotein cholesterol ratio and H‑type hypertension: a cross‑sectional study in Chinese adults.
9 affiliations
- 1Clinical Epidemiology Research Office, The First Affiliated Hospital of Hunan Normal University, Changsha, China.
- 2Key Laboratory of Molecular Epidemiology, Hunan Normal University, Changsha, China.
- 3Department of Epidemiology and Statistics, Hunan Normal University, Changsha, China.
- 4Medical Department, Hunan Normal University, Changsha, China.
- 5Clinical Epidemiology Research Office, The First Affiliated Hospital of Hunan Normal University, Changsha, China. [email protected].
- 6Clinical Epidemiology Research Office, The First Affiliated Hospital of Hunan Normal University, Changsha, China. [email protected].
- 7Key Laboratory of Molecular Epidemiology, Hunan Normal University, Changsha, China. [email protected].
- 8Department of Epidemiology and Statistics, Hunan Normal University, Changsha, China. [email protected].
- 9Medical Department, Hunan Normal University, Changsha, China. [email protected].
Abstract
Background
The uric acid to high-density lipoprotein cholesterol ratio (UHR) is a novel inflammatory and metabolic biomarker. Studies have confirmed that it is closely associated with the onset and progression of various metabolic and cardiovascular diseases. However, the relationship between UHR and H-type hypertension (HTH) remains unclear. This study aims to investigate the association between the UHR and HTH.Methods
This study was conducted as a cross-sectional analysis. The study population consisted of adults aged over 30 years from six randomly selected regions in Hunan Province, China, among whom 1,835 eligible participants were included in the analysis.Data were collected through questionnaire surveys, physical examinations, and laboratory tests. Logistic regression model was used to analyze the association between the UHR index and HTH. RCS were used to assess the potential nonlinear relationship between the two variables. Subgroup analyses were conducted to explore the interaction effects of different subgroups on the association between UHR and HTH. ROC curves were applied to evaluate the discriminatory ability of UHR for HTH.Results
The analysis included 1835 participants, of whom 1026 had HTH, and 1,069 participants (58.3%) were female. Multivariate logistic regression analysis showed that, each one‑standard‑deviation increase in the UHR index was associated with a 40% increase in the risk of HTH (OR = 1.41, 95%CI: 1.24-1.60, P < 0.001). RCS analysis indicated a nonlinear dose-response relationship between the UHR index and the risk of HTH (P for nonlinear = 0.045). We further identified an inflection point of the threshold effect of UHR, above and below which the prevalence of HTH exhibited distinct increasing trends.Subgroup analysis showed that the association between UHR and HTH was more pronounced in females and the Han Chinese population. ROC curve analysis demonstrated that UHR had moderate discriminatory ability for HTH, with AUC of 0.618 (95%CI: 0.592-0.644, P < 0.001).Conclusion
UHR is independently associated with HTH and exhibits a positive nonlinear association with the condition, with an inflection point at 0.09.
Related
- Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio as a lipid-based marker of hypertension: a large-scale cross-sectional investigation
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- Association between the uric acid to high-density lipoprotein cholesterol ratio and diabetic kidney disease in U.S. adults with type 2 diabetes: A cross-sectional study of NHANES 2009 to 2018.
- Association between the fasting blood glucose to high-density lipoprotein cholesterol ratio and non-alcoholic fatty liver disease in Chinese adults: a secondary analysis
- Joint association of the cholesterol–high-density lipoprotein–glucose index and waist-to-height ratio with incident cardiovascular disease in a high-risk Chinese cohort
BibTeX
@article{jiang2026association,
title = {{Association between the uric acid to high‑density lipoprotein cholesterol ratio and H‑type hypertension: a cross‑sectional study in Chinese adults.}},
author = {Na Jiang and Liwen Zhu and Minqi Li and Yiwei Peng and Xuan Tan and Ling Li and Xiuqin Hong},
journal = {BMC cardiovascular disorders},
year = {2026},
month = aug,
doi = {10.1186/s12872-026-06404-5},
url = {https://europepmc.org/article/MED/42967989},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Association between the uric acid to high‑density lipoprotein cholesterol ratio and H‑type hypertension: a cross‑sectional study in Chinese adults.
AU - Na Jiang
AU - Liwen Zhu
AU - Minqi Li
AU - Yiwei Peng
AU - Xuan Tan
AU - Ling Li
AU - Xiuqin Hong
PY - 2026
DA - 2026/08/05
JO - BMC cardiovascular disorders
DO - 10.1186/s12872-026-06404-5
UR - https://europepmc.org/article/MED/42967989
AB - Background The uric acid to high-density lipoprotein cholesterol ratio (UHR) is a novel inflammatory and metabolic biomarker. Studies have confirmed that it is closely associated with the onset and progression of various metabolic and cardiovascular diseases. However, the relationship between UHR and H-type hypertension (HTH) remains unclear. This study aims to investigate the association between the UHR and HTH.Methods This study was conducted as a cross-sectional analysis. The study population consisted of adults aged over 30 years from six randomly selected regions in Hunan Province, China, among whom 1,835 eligible participants were included in the analysis.Data were collected through questionnaire surveys, physical examinations, and laboratory tests. Logistic regression model was used to analyze the association between the UHR index and HTH. RCS were used to assess the potential nonlinear relationship between the two variables. Subgroup analyses were conducted to explore the interaction effects of different subgroups on the association between UHR and HTH. ROC curves were applied to evaluate the discriminatory ability of UHR for HTH.Results The analysis included 1835 participants, of whom 1026 had HTH, and 1,069 participants (58.3%) were female. Multivariate logistic regression analysis showed that, each one‑standard‑deviation increase in the UHR index was associated with a 40% increase in the risk of HTH (OR = 1.41, 95%CI: 1.24-1.60, P < 0.001). RCS analysis indicated a nonlinear dose-response relationship between the UHR index and the risk of HTH (P for nonlinear = 0.045). We further identified an inflection point of the threshold effect of UHR, above and below which the prevalence of HTH exhibited distinct increasing trends.Subgroup analysis showed that the association between UHR and HTH was more pronounced in females and the Han Chinese population. ROC curve analysis demonstrated that UHR had moderate discriminatory ability for HTH, with AUC of 0.618 (95%CI: 0.592-0.644, P < 0.001).Conclusion UHR is independently associated with HTH and exhibits a positive nonlinear association with the condition, with an inflection point at 0.09.
SN - 1471-2261
ER -