Acute Heat Stress Disrupts Hepatic Homeostasis and Gut Microbiota in Early-Juvenile Asian Swamp Eels (Monopterus albus).
- 1Hubei Key Laboratory of Waterlogging Disaster and Agricultural Use of Wetland, College of Animal Science and Technology, Yangtze University, Jingzhou 434000, China.
- 2Jingzhou Taihu Port Aquatic Science and Technology Co., Ltd., Jingzhou 434026, China.
- 3Honghu Laboratory, College of Animal Science and Technology, Yangtze University, Jingzhou 434023, China.
Abstract
Water temperature is a critical environmental determinant of aquatic organism survival. The Asian swamp eel (Monopterus albus), a major aquaculture species, is highly vulnerable to acute summer heat stress at the early-juvenile stage. Juveniles exposed to 32 °C for 96 h (versus 25 °C controls) exhibited 3498 differentially expressed hepatic genes, with enrichment in amino acid metabolism, immune regulation, and apoptosis pathways; immunity, metabolism, and ion binding were top enriched functions. Key genes linked to immune activation, apoptosis, and metabolic reprogramming were upregulated. Gut 16S rRNA profiling revealed increased microbial diversity and taxonomic shifts indicative of microbiota disruption. These findings show that acute heat stress disrupts hepatic homeostasis via coordinated inflammatory, apoptotic, and metabolic responses while altering gut microbiota, offering an integrated view of thermal resilience mechanisms in early-life-stage teleosts.
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BibTeX
@article{yi2026acute,
title = {{Acute Heat Stress Disrupts Hepatic Homeostasis and Gut Microbiota in Early-Juvenile Asian Swamp Eels (Monopterus albus).}},
author = {Tilin Yi and Kangquan Yu and Jinnan Li and Heng Zhang and Daiqin Yang and Feng Chen},
journal = {Animals : an open access journal from MDPI},
year = {2026},
month = oct,
doi = {10.3390/ani16203206},
url = {https://europepmc.org/article/MED/42939136},
note = {CC BY},
}
RIS
TY - JOUR
TI - Acute Heat Stress Disrupts Hepatic Homeostasis and Gut Microbiota in Early-Juvenile Asian Swamp Eels (Monopterus albus).
AU - Tilin Yi
AU - Kangquan Yu
AU - Jinnan Li
AU - Heng Zhang
AU - Daiqin Yang
AU - Feng Chen
PY - 2026
DA - 2026/10/12
JO - Animals : an open access journal from MDPI
DO - 10.3390/ani16203206
UR - https://europepmc.org/article/MED/42939136
AB - Water temperature is a critical environmental determinant of aquatic organism survival. The Asian swamp eel (Monopterus albus), a major aquaculture species, is highly vulnerable to acute summer heat stress at the early-juvenile stage. Juveniles exposed to 32 °C for 96 h (versus 25 °C controls) exhibited 3498 differentially expressed hepatic genes, with enrichment in amino acid metabolism, immune regulation, and apoptosis pathways; immunity, metabolism, and ion binding were top enriched functions. Key genes linked to immune activation, apoptosis, and metabolic reprogramming were upregulated. Gut 16S rRNA profiling revealed increased microbial diversity and taxonomic shifts indicative of microbiota disruption. These findings show that acute heat stress disrupts hepatic homeostasis via coordinated inflammatory, apoptotic, and metabolic responses while altering gut microbiota, offering an integrated view of thermal resilience mechanisms in early-life-stage teleosts.
SN - 2076-2615
ER -