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Peer-reviewedCC BYActa cirurgica brasileira

The effect of intraperitoneal St. John's Wort oil (Hypericum perforatum) in an experimental peritonitis model.

  • Yunus Kayci1,2
  • Burak Yavuz2
  • Ahmet Onur Demirel2
  • Ibrahim Çoğal2
  • Zülfi Zahidli2
  • Kivilcim Eren Ateş3
  • Uğur Topal2
  • Ismail Cem Eray2
  • Mustafa Yalçın Kekeç2
  1. 1University of Health Sciences - Adana City Training and Research Hospital - Department of Gastroenterological Surgery - Adana - Turkey.
  2. 2Çukurova University - Faculty of Medicine - Department of General Surgery - Adana - Turkey.
  3. 3Çukurova University - Faculty of Medicine - Department of Pathology - Adana - Turkey.
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Abstract

Purpose

To evaluate the effects of intraperitoneal Hypericum perforatum oil (St. John's Wort oil, SJWO) on systemic inflammation and peritoneal histopathology in experimental peritonitis.Methods

Forty-two male Wistar Albino rats were randomized into seven groups (n = 6): control, SJWO, olive oil, peritonitis, peritonitis + saline, peritonitis + SJWO, and peritonitis + olive oil. Peritonitis was induced with freshly prepared autologous fecal suspension, and treatments were administered intraperitoneally at 48 h. On day 5, plasma inflammatory markers, peritoneal thickness, and histopathological scores were assessed blinded.Results

The greatest weight loss was seen in the peritonitis group (p = 0.002). SJWO did not consistently reduce systemic inflammatory markers. Compared with peritonitis + saline, peritonitis + SJWO showed lower parietal fibrosis and vascular proliferation scores (rank-biserial correlation for each outcome, r rb = -0.833; 95% confidence interval -1.000 to -0.500), but visceral fibrosis was not reduced.Conclusion

Intraperitoneal SJWO did not suppress systemic inflammation. The lower early parietal fibrosis and vascular proliferation scores are exploratory because the effect was not observed in visceral tissue, and adhesion formation was not directly assessed.

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Cite

BibTeXRIS
BibTeX
@article{kayci2026effect,
  title = {{The effect of intraperitoneal St. John's Wort oil (Hypericum perforatum) in an experimental peritonitis model.}},
  author = {Yunus Kayci and Burak Yavuz and Ahmet Onur Demirel and Ibrahim Çoğal and Zülfi Zahidli and Kivilcim Eren Ateş and Uğur Topal and Ismail Cem Eray and Mustafa Yalçın Kekeç},
  journal = {Acta cirurgica brasileira},
  year = {2026},
  month = oct,
  doi = {10.1590/acb416026},
  url = {https://europepmc.org/article/MED/42912006},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - The effect of intraperitoneal St. John's Wort oil (Hypericum perforatum) in an experimental peritonitis model.
AU  - Yunus Kayci
AU  - Burak Yavuz
AU  - Ahmet Onur Demirel
AU  - Ibrahim Çoğal
AU  - Zülfi Zahidli
AU  - Kivilcim Eren Ateş
AU  - Uğur Topal
AU  - Ismail Cem Eray
AU  - Mustafa Yalçın Kekeç
PY  - 2026
DA  - 2026/10/19
JO  - Acta cirurgica brasileira
DO  - 10.1590/acb416026
UR  - https://europepmc.org/article/MED/42912006
AB  - Purpose  To evaluate the effects of intraperitoneal Hypericum perforatum oil (St. John's Wort oil, SJWO) on systemic inflammation and peritoneal histopathology in experimental peritonitis.Methods  Forty-two male Wistar Albino rats were randomized into seven groups (n = 6): control, SJWO, olive oil, peritonitis, peritonitis + saline, peritonitis + SJWO, and peritonitis + olive oil. Peritonitis was induced with freshly prepared autologous fecal suspension, and treatments were administered intraperitoneally at 48 h. On day 5, plasma inflammatory markers, peritoneal thickness, and histopathological scores were assessed blinded.Results  The greatest weight loss was seen in the peritonitis group (p = 0.002). SJWO did not consistently reduce systemic inflammatory markers. Compared with peritonitis + saline, peritonitis + SJWO showed lower parietal fibrosis and vascular proliferation scores (rank-biserial correlation for each outcome, r rb = -0.833; 95% confidence interval -1.000 to -0.500), but visceral fibrosis was not reduced.Conclusion  Intraperitoneal SJWO did not suppress systemic inflammation. The lower early parietal fibrosis and vascular proliferation scores are exploratory because the effect was not observed in visceral tissue, and adhesion formation was not directly assessed.
SN  - 0102-8650
SN  - 1678-2674
ER  -