Cascaded Nano-ring Dialyzer for Continuous Regenerative Peritoneal Dialysis
- 1Harvard Medical School
Abstract
End-stage kidney disease (ESKD) requires lifelong kidney replacement therapy, yet conventional hemodialysis and peritoneal dialysis remain limited by intermittent treatment, restricted mobility, and repeated dialysate exchange. Here, we developed a continuous regenerative peritoneal dialysis platform based on a nano-ring-assisted nanoelectrokinetic dialyzer for portable artificial kidney applications. We first identified key geometric and electrokinetic parameters governing the removal performance of nano-ring meshes, including mesh dimension, nano-ring coating thickness, the number of cascaded nano-rings, and the relative orientation between fluid flow and the applied electric field. We then developed a single nano-ring dialyzer operating at 1.33 mL/min and scaled the treatment capacity to approximately 10 mL min/min through parallel integration of multiple modules. In a canine model, the closed-loop system achieved approximately 10 % reduction in circulating uremic toxin levels during continuous treatment. We further improved the biocompatibility of the regenerated dialysate by integrating plate-type electrodes, activated carbon, bicarbonate buffering, and UV-C treatment. In an unanesthetized canine model, the improved system sustained continuous toxin removal for 4 h while major hepatic and inflammatory markers remained within recoverable ranges. These results demonstrate that cascaded nano-ring enables continuous dialysate regeneration with scalable throughput, reduced dependence on fresh dialysate, and in vivo control of uremic toxins, providing a technological foundation for portable or wearable regenerative peritoneal dialysis systems.
Related
- Dynamic reconfiguration of brain activity states in peritoneal dialysis patients: a Hidden Markov Model study
- Cascaded Dual-Targeting (WTW/TAT) Liposomes Delivery DOX for Precision Glioblastoma Treatment
- Macrophage states and immunometabolic adaptation in peritoneal metastases from colorectal cancer
- A cascaded U-nets model based on hybrid attention for video anomaly detection
- A cascaded parallel deep learning framework for precise potato canopy density mapping via edge-aware feature fusion
BibTeX
@misc{kim2026cascaded,
title = {{Cascaded Nano-ring Dialyzer for Continuous Regenerative Peritoneal Dialysis}},
author = {W. Kim and K. Kim and S. Hong and S. Lee and H. Lee and D. A. Shin and S. H. Yang and K. Kim and J. Lee and K. J. Lee and W. S. Cho and H. Lee and D. K. Kim and H. C. Kim and M. Seo and D. Kim and L. P. Lee and Y. S. Kim and J. C. Lee and G. Y. Sung and S. J. Kim},
howpublished = {bioRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.14.751343},
url = {https://www.biorxiv.org/content/10.64898/2026.09.14.751343v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - Cascaded Nano-ring Dialyzer for Continuous Regenerative Peritoneal Dialysis
AU - W. Kim
AU - K. Kim
AU - S. Hong
AU - S. Lee
AU - H. Lee
AU - D. A. Shin
AU - S. H. Yang
AU - K. Kim
AU - J. Lee
AU - K. J. Lee
AU - W. S. Cho
AU - H. Lee
AU - D. K. Kim
AU - H. C. Kim
AU - M. Seo
AU - D. Kim
AU - L. P. Lee
AU - Y. S. Kim
AU - J. C. Lee
AU - G. Y. Sung
AU - S. J. Kim
PY - 2026
DA - 2026/09/14
PB - bioRxiv
DO - 10.64898/2026.09.14.751343
UR - https://www.biorxiv.org/content/10.64898/2026.09.14.751343v1
AB - End-stage kidney disease (ESKD) requires lifelong kidney replacement therapy, yet conventional hemodialysis and peritoneal dialysis remain limited by intermittent treatment, restricted mobility, and repeated dialysate exchange. Here, we developed a continuous regenerative peritoneal dialysis platform based on a nano-ring-assisted nanoelectrokinetic dialyzer for portable artificial kidney applications. We first identified key geometric and electrokinetic parameters governing the removal performance of nano-ring meshes, including mesh dimension, nano-ring coating thickness, the number of cascaded nano-rings, and the relative orientation between fluid flow and the applied electric field. We then developed a single nano-ring dialyzer operating at 1.33 mL/min and scaled the treatment capacity to approximately 10 mL min/min through parallel integration of multiple modules. In a canine model, the closed-loop system achieved approximately 10 % reduction in circulating uremic toxin levels during continuous treatment. We further improved the biocompatibility of the regenerated dialysate by integrating plate-type electrodes, activated carbon, bicarbonate buffering, and UV-C treatment. In an unanesthetized canine model, the improved system sustained continuous toxin removal for 4 h while major hepatic and inflammatory markers remained within recoverable ranges. These results demonstrate that cascaded nano-ring enables continuous dialysate regeneration with scalable throughput, reduced dependence on fresh dialysate, and in vivo control of uremic toxins, providing a technological foundation for portable or wearable regenerative peritoneal dialysis systems.
ER -