Echo Intensity Band Analysis for Assessing Skeletal Muscle Quality in Older Women with Type 2 Diabetes and Peripheral Arterial Disease.
- 1Human Performance Laboratory, Faculty of Physical Education and Physiotherapy, Federal University of Amazonas, Manaus 69077-000, Brazil.
- 2Biomechanics Laboratory, Center of Physical Education and Sports, Federal University of Santa Maria, Santa Maria Rio Grande do Sul 97105-900, Brazil.
Abstract
Background: Type 2 Diabetes Mellitus (T2DM) and Peripheral Arterial Disease (PAD) are associated with impaired skeletal muscle quality; however, the impact of T2DM alone and the additional burden of concomitant PAD on echo intensity (EI) band distribution remain unclear. This study evaluated these associations in older women using EI band analysis. Methods: Twenty-four older women were allocated into three age-matched groups: GT2DM + PAD (n = 8), GT2DM (n = 8), and healthy participants (HPG; n = 8). Ultrasound images of the vastus lateralis (VL), Tibialis Anterior (TA), Rectus Femoris (RF), and Medial Gastrocnemius (MG) were obtained. Muscle quality was assessed by pixel distribution across EI bands (0 to 255 A.U.) Results: In the VL, the GT2DM + PAD showed a significantly lower percentage of pixels in the 0-50 band compared with GT2DM (p = 0.020) and HPG (p = 0.039), and higher percentages in the 51-100 band (p = 0.018 and p = 0.030, respectively). For the MG, both GT2DM and GT2DM + PAD exhibited fewer pixels in the 0-50 band and higher values in the 51-100, 101-150, and 151-200 bands than HPG (p < 0.05). Conclusions: T2DM, alone or combined with PAD, was associated with altered skeletal muscle quality, characterized by a shift toward higher EI bands, suggesting increased non-contractile tissue content.
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BibTeX
@article{silva2026echo,
title = {{Echo Intensity Band Analysis for Assessing Skeletal Muscle Quality in Older Women with Type 2 Diabetes and Peripheral Arterial Disease.}},
author = {Filipi Manoel Silva and Luiz Henrique Rufino Batista and Silas Nery de Oliveira and Francisco Thalyson Moraes Silveira and Fábio Juner Lanferdini and Mateus Rossato},
journal = {Journal of functional morphology and kinesiology},
year = {2026},
month = sep,
doi = {10.3390/jfmk11040377},
url = {https://europepmc.org/article/MED/42924656},
note = {CC BY},
}
RIS
TY - JOUR
TI - Echo Intensity Band Analysis for Assessing Skeletal Muscle Quality in Older Women with Type 2 Diabetes and Peripheral Arterial Disease.
AU - Filipi Manoel Silva
AU - Luiz Henrique Rufino Batista
AU - Silas Nery de Oliveira
AU - Francisco Thalyson Moraes Silveira
AU - Fábio Juner Lanferdini
AU - Mateus Rossato
PY - 2026
DA - 2026/09/23
JO - Journal of functional morphology and kinesiology
DO - 10.3390/jfmk11040377
UR - https://europepmc.org/article/MED/42924656
AB - Background: Type 2 Diabetes Mellitus (T2DM) and Peripheral Arterial Disease (PAD) are associated with impaired skeletal muscle quality; however, the impact of T2DM alone and the additional burden of concomitant PAD on echo intensity (EI) band distribution remain unclear. This study evaluated these associations in older women using EI band analysis. Methods: Twenty-four older women were allocated into three age-matched groups: GT2DM + PAD (n = 8), GT2DM (n = 8), and healthy participants (HPG; n = 8). Ultrasound images of the vastus lateralis (VL), Tibialis Anterior (TA), Rectus Femoris (RF), and Medial Gastrocnemius (MG) were obtained. Muscle quality was assessed by pixel distribution across EI bands (0 to 255 A.U.) Results: In the VL, the GT2DM + PAD showed a significantly lower percentage of pixels in the 0-50 band compared with GT2DM (p = 0.020) and HPG (p = 0.039), and higher percentages in the 51-100 band (p = 0.018 and p = 0.030, respectively). For the MG, both GT2DM and GT2DM + PAD exhibited fewer pixels in the 0-50 band and higher values in the 51-100, 101-150, and 151-200 bands than HPG (p < 0.05). Conclusions: T2DM, alone or combined with PAD, was associated with altered skeletal muscle quality, characterized by a shift toward higher EI bands, suggesting increased non-contractile tissue content.
SN - 2411-5142
ER -